OCA at 07:43, 8 March 2023

OCA — Wed, 08 Mar 2023 07:43:06 GMT

←Older revision		Revision as of 07:43, 8 March 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7sfr is ~~ON HOLD until Paper~~ Publication	+	==Unmethylated Mtb Ribosome 50S with SEQ-9==
		+	<StructureSection load='7sfr' size='340' side='right'caption='[[7sfr]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7sfr]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SFR FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=4OC:4N,O2-METHYLCYTIDINE-5-MONOPHOSPHATE'>4OC</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=MA6:6N-DIMETHYLADENOSINE-5-MONOPHOSHATE'>MA6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene>, <scene name='pdbligand=WDP:Sequanamycin+9'>WDP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sfr OCA], [https://pdbe.org/7sfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sfr RCSB], [https://www.ebi.ac.uk/pdbsum/7sfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sfr ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A045HU18_MYCTX A0A045HU18_MYCTX] One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.[HAMAP-Rule:MF_01325][RuleBase:RU003906]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The emergence of drug-resistant tuberculosis has created an urgent need for new anti-tubercular agents. Here, we report the discovery of a series of macrolides called sequanamycins with outstanding in vitro and in vivo activity against Mycobacterium tuberculosis (Mtb). Sequanamycins are bacterial ribosome inhibitors that interact with the ribosome in a similar manner to classic macrolides like erythromycin and clarithromycin, but with binding characteristics that allow them to overcome the inherent macrolide resistance of Mtb. Structures of the ribosome with bound inhibitors were used to optimize sequanamycin to produce the advanced lead compound SEQ-9. SEQ-9 was efficacious in mouse models of acute and chronic TB as a single agent, and it demonstrated bactericidal activity in a murine TB infection model in combination with other TB drugs. These results support further investigation of this series as TB clinical candidates, with the potential for use in new regimens against drug-susceptible and drug-resistant TB.

-	~~Authors~~:	+	Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.,Zhang J, Lair C, Roubert C, Amaning K, Barrio MB, Benedetti Y, Cui Z, Xing Z, Li X, Franzblau SG, Baurin N, Bordon-Pallier F, Cantalloube C, Sans S, Silve S, Blanc I, Fraisse L, Rak A, Jenner LB, Yusupova G, Yusupov M, Zhang J, Kaneko T, Yang TJ, Fotouhi N, Nuermberger E, Tyagi S, Betoudji F, Upton A, Sacchettini JC, Lagrange S Cell. 2023 Mar 2;186(5):1013-1025.e24. doi: 10.1016/j.cell.2023.01.043. Epub 2023 , Feb 23. PMID:36827973<ref>PMID:36827973</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7sfr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Cui Z]]
		+	[[Category: Xing Z]]
		+	[[Category: Zhang J]]

OCA at 15:37, 15 December 2021

OCA — Wed, 15 Dec 2021 15:37:40 GMT

←Older revision		Revision as of 15:37, 15 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7sfr is ON HOLD	+	The entry 7sfr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7sfr" [edit=sysop:move=sysop]

OCA — Wed, 13 Oct 2021 10:27:37 GMT

Protected "7sfr" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:27, 13 October 2021

OCA: New page: '''Unreleased structure''' The entry 7sfr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Oct 2021 10:27:36 GMT

New page: '''Unreleased structure''' The entry 7sfr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7sfr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7sfr - Revision history

OCA at 07:43, 8 March 2023

OCA at 15:37, 15 December 2021

OCA: Protected "7sfr" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7sfr is ON HOLD Authors: Description: Category: Unreleased Structures