OCA at 04:15, 8 September 2022

OCA — Thu, 08 Sep 2022 04:15:07 GMT

←Older revision		Revision as of 04:15, 8 September 2022
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-	====	+	==Cryo-EM structure of human ACKR3 in complex with chemokine N-terminal mutant CXCL12_LRHQ and an intracellular Fab==
-	<StructureSection load='7sk6' size='340' side='right'caption='[[7sk6]]' scene=''>	+	<StructureSection load='7sk6' size='340' side='right'caption='[[7sk6]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7sk6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SK6 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sk6 OCA], [https://pdbe.org/7sk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sk6 RCSB], [https://www.ebi.ac.uk/pdbsum/7sk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sk6 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sk6 OCA], [https://pdbe.org/7sk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sk6 RCSB], [https://www.ebi.ac.uk/pdbsum/7sk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sk6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/ACKR3_HUMAN ACKR3_HUMAN]] Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.<ref>PMID:16107333</ref> <ref>PMID:16940167</ref> <ref>PMID:17804806</ref> <ref>PMID:18653785</ref> <ref>PMID:19255243</ref> <ref>PMID:19380869</ref> <ref>PMID:19641136</ref> <ref>PMID:20018651</ref> <ref>PMID:20161793</ref> <ref>PMID:20388803</ref> <ref>PMID:20887389</ref> <ref>PMID:22300987</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Both CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are activated by the chemokine CXCL12 yet evoke distinct cellular responses. CXCR4 is a canonical G protein-coupled receptor (GPCR), whereas ACKR3 is intrinsically biased for arrestin. The molecular basis for this difference is not understood. Here, we describe cryo-EM structures of ACKR3 in complex with CXCL12, a more potent CXCL12 variant, and a small-molecule agonist. The bound chemokines adopt an unexpected pose relative to those established for CXCR4 and observed in other receptor-chemokine complexes. Along with functional studies, these structures provide insight into the ligand-binding promiscuity of ACKR3, why it fails to couple to G proteins, and its bias toward beta-arrestin. The results lay the groundwork for understanding the physiological interplay of ACKR3 with other GPCRs.
		+
		+	Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.,Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM Sci Adv. 2022 Jul 15;8(28):eabn8063. doi: 10.1126/sciadv.abn8063. Epub 2022 Jul, 13. PMID:35857509<ref>PMID:35857509</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7sk6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Gustavsson M]]
		+	[[Category: Handel TM]]
		+	[[Category: Schafer CT]]
		+	[[Category: Tesmer JJG]]
		+	[[Category: Yen YC]]

OCA at 18:03, 27 July 2022

OCA — Wed, 27 Jul 2022 18:03:58 GMT

←Older revision		Revision as of 18:03, 27 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7sk6 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7sk6' size='340' side='right'caption='[[7sk6]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sk6 OCA], [https://pdbe.org/7sk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sk6 RCSB], [https://www.ebi.ac.uk/pdbsum/7sk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sk6 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 03:49, 8 June 2022

OCA — Wed, 08 Jun 2022 03:49:22 GMT

←Older revision		Revision as of 03:49, 8 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7sk6 is ON HOLD	+	The entry 7sk6 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 09:45, 23 March 2022

OCA — Wed, 23 Mar 2022 09:45:26 GMT

←Older revision		Revision as of 09:45, 23 March 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7sk6 is ON HOLD ~~until Paper Publication~~	+	The entry 7sk6 is ON HOLD

	Authors:		Authors:

OCA at 05:09, 1 December 2021

OCA — Wed, 01 Dec 2021 05:09:17 GMT

←Older revision		Revision as of 05:09, 1 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7sk6 is ON HOLD	+	The entry 7sk6 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7sk6" [edit=sysop:move=sysop]

OCA — Wed, 27 Oct 2021 12:46:49 GMT

Protected "7sk6" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:46, 27 October 2021

OCA: New page: '''Unreleased structure''' The entry 7sk6 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Oct 2021 12:46:48 GMT

New page: '''Unreleased structure''' The entry 7sk6 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7sk6 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]