7skz - Revision history

OCA at 16:52, 18 October 2023

OCA — Wed, 18 Oct 2023 16:52:46 GMT

←Older revision		Revision as of 16:52, 18 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7skz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SKZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[7skz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SKZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7skz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7skz OCA], [https://pdbe.org/7skz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7skz RCSB], [https://www.ebi.ac.uk/pdbsum/7skz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7skz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7skz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7skz OCA], [https://pdbe.org/7skz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7skz RCSB], [https://www.ebi.ac.uk/pdbsum/7skz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7skz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:53, 8 September 2022

OCA — Thu, 08 Sep 2022 03:53:11 GMT

←Older revision		Revision as of 03:53, 8 September 2022
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	==Crystal Structure of VN01H1 Fab in complex with SARS-CoV-2 S fusion peptide==		==Crystal Structure of VN01H1 Fab in complex with SARS-CoV-2 S fusion peptide==
-	<StructureSection load='7skz' size='340' side='right'caption='[[7skz]]' scene=''>	+	<StructureSection load='7skz' size='340' side='right'caption='[[7skz]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SKZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7skz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SKZ FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7skz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7skz OCA], [https://pdbe.org/7skz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7skz RCSB], [https://www.ebi.ac.uk/pdbsum/7skz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7skz ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7skz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7skz OCA], [https://pdbe.org/7skz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7skz RCSB], [https://www.ebi.ac.uk/pdbsum/7skz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7skz ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The coronavirus spike glycoprotein attaches to host receptors and mediates viral fusion. Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that bind to all human-infecting coronavirus spike proteins from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune donors. These mAbs recognize the fusion peptide and acquire affinity and breadth through somatic mutations. Despite targeting a conserved motif, only some mAbs show broad neutralizing activity in vitro against alpha- and betacoronaviruses, including animal coronaviruses WIV-1 and PDF-2180. Two selected mAbs also neutralize Omicron BA.1 and BA.2 authentic viruses and reduce viral burden and pathology in vivo. Structural and functional analyses showed that the fusion peptide-specific mAbs bound with different modalities to a cryptic epitope hidden in prefusion stabilized spike, which became exposed upon binding of angiotensin-converting enzyme 2 (ACE2) or ACE2-mimicking mAbs.
		+
		+	ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies.,Low JS, Jerak J, Tortorici MA, McCallum M, Pinto D, Cassotta A, Foglierini M, Mele F, Abdelnabi R, Weynand B, Noack J, Montiel-Ruiz M, Bianchi S, Benigni F, Sprugasci N, Joshi A, Bowen JE, Stewart C, Rexhepaj M, Walls AC, Jarrossay D, Morone D, Paparoditis P, Garzoni C, Ferrari P, Ceschi A, Neyts J, Purcell LA, Snell G, Corti D, Lanzavecchia A, Veesler D, Sallusto F Science. 2022 Aug 12;377(6607):735-742. doi: 10.1126/science.abq2679. Epub 2022, Jul 12. PMID:35857703<ref>PMID:35857703</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7skz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
	[[Category: Tortorici MA]]		[[Category: Tortorici MA]]
	[[Category: Veesler D]]		[[Category: Veesler D]]

OCA at 11:07, 31 August 2022

OCA — Wed, 31 Aug 2022 11:07:28 GMT

←Older revision		Revision as of 11:07, 31 August 2022
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-	====	+	==Crystal Structure of VN01H1 Fab in complex with SARS-CoV-2 S fusion peptide==
	<StructureSection load='7skz' size='340' side='right'caption='[[7skz]]' scene=''>		<StructureSection load='7skz' size='340' side='right'caption='[[7skz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SKZ FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7skz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7skz OCA], [https://pdbe.org/7skz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7skz RCSB], [https://www.ebi.ac.uk/pdbsum/7skz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7skz ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7skz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7skz OCA], [https://pdbe.org/7skz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7skz RCSB], [https://www.ebi.ac.uk/pdbsum/7skz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7skz ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Tortorici MA]]
		+	[[Category: Veesler D]]

OCA at 06:51, 20 July 2022

OCA — Wed, 20 Jul 2022 06:51:38 GMT

←Older revision		Revision as of 06:51, 20 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7skz ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7skz' size='340' side='right'caption='[[7skz]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7skz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7skz OCA], [https://pdbe.org/7skz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7skz RCSB], [https://www.ebi.ac.uk/pdbsum/7skz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7skz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7skz" [edit=sysop:move=sysop]

OCA — Wed, 27 Oct 2021 12:48:21 GMT

Protected "7skz" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:48, 27 October 2021

OCA: New page: '''Unreleased structure''' The entry 7skz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Oct 2021 12:48:20 GMT

New page: '''Unreleased structure''' The entry 7skz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7skz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]