7sqp - Revision history

OCA at 09:38, 25 October 2023

OCA — Wed, 25 Oct 2023 09:38:29 GMT

←Older revision		Revision as of 09:38, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7sqp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16] and [https://en.wikipedia.org/wiki/Pongo_pygmaeus Pongo pygmaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SQP FirstGlance]. <br>		<table><tr><td colspan='2'>[[7sqp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16] and [https://en.wikipedia.org/wiki/Pongo_pygmaeus Pongo pygmaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SQP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sqp OCA], [https://pdbe.org/7sqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sqp RCSB], [https://www.ebi.ac.uk/pdbsum/7sqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sqp ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.53Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sqp OCA], [https://pdbe.org/7sqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sqp RCSB], [https://www.ebi.ac.uk/pdbsum/7sqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sqp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:04, 24 November 2022

OCA — Thu, 24 Nov 2022 10:04:42 GMT

←Older revision		Revision as of 10:04, 24 November 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7sqp is ~~ON HOLD until Paper Publication~~	+	==Single chain trimer HLA-A*02:01 (Y108C) with HPV.16 E7 peptide YMLDLQPETTDL==
-		+	<StructureSection load='7sqp' size='340' side='right'caption='[[7sqp]], [[Resolution\|resolution]] 2.53Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7sqp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16] and [https://en.wikipedia.org/wiki/Pongo_pygmaeus Pongo pygmaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SQP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sqp OCA], [https://pdbe.org/7sqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sqp RCSB], [https://www.ebi.ac.uk/pdbsum/7sqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sqp ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A678ZGP6_HUMAN A0A678ZGP6_HUMAN] [https://www.uniprot.org/uniprot/VE7_HPV16 VE7_HPV16] Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).[HAMAP-Rule:MF_04004]<ref>PMID:11080488</ref> <ref>PMID:1316611</ref> <ref>PMID:2836062</ref> [https://www.uniprot.org/uniprot/B2MG_PONPY B2MG_PONPY] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Human papillomavirus type 16]]
		+	[[Category: Large Structures]]
		+	[[Category: Pongo pygmaeus]]
		+	[[Category: Finton KAK]]
		+	[[Category: Rupert PB]]

OCA at 15:38, 15 December 2021

OCA — Wed, 15 Dec 2021 15:38:26 GMT

←Older revision		Revision as of 15:38, 15 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7sqp is ON HOLD	+	The entry 7sqp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7sqp" [edit=sysop:move=sysop]

OCA — Wed, 17 Nov 2021 12:13:25 GMT

Protected "7sqp" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:13, 17 November 2021

OCA: New page: '''Unreleased structure''' The entry 7sqp is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 17 Nov 2021 12:13:24 GMT

New page: '''Unreleased structure''' The entry 7sqp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7sqp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]