7stn - Revision history

OCA at 04:45, 8 September 2022

OCA — Thu, 08 Sep 2022 04:45:07 GMT

←Older revision		Revision as of 04:45, 8 September 2022
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	<StructureSection load='7stn' size='340' side='right'caption='[[7stn]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='7stn' size='340' side='right'caption='[[7stn]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7stn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7STN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7STN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7stn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7STN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7STN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=BGI:(2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]acetic+acid+(non-preferred+name)'>BGI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=BGI:(2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]acetic+acid+(non-preferred+name)'>BGI</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chitin_synthase Chitin synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.16 2.4.1.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7stn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7stn OCA], [https://pdbe.org/7stn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7stn RCSB], [https://www.ebi.ac.uk/pdbsum/7stn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7stn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7stn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7stn OCA], [https://pdbe.org/7stn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7stn RCSB], [https://www.ebi.ac.uk/pdbsum/7stn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7stn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/A0A1D8PTV3_CANAL A0A1D8PTV3_CANAL]]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chitin synthase~~]]	+	[[Category: Candida albicans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chhetri, A]]	+	[[Category: Chhetri A]]
-	[[Category: Lee, S]]	+	[[Category: Lee S]]
-	[[Category: Ren, Z]]	+	[[Category: Ren Z]]
-	[[Category: Yokoyama, K]]	+	[[Category: Yokoyama K]]
-	~~[[Category: Chitin synthesis]]~~	+
-	~~[[Category: Glycosyltransferase]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Nikkomycin z]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 18:18, 27 July 2022

OCA — Wed, 27 Jul 2022 18:18:06 GMT

←Older revision		Revision as of 18:18, 27 July 2022
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	==Chitin Synthase 2 from Candida albicans bound to Nikkomycin Z==		==Chitin Synthase 2 from Candida albicans bound to Nikkomycin Z==
-	<StructureSection load='7stn' size='340' side='right'caption='[[7stn]]' scene=''>	+	<StructureSection load='7stn' size='340' side='right'caption='[[7stn]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7STN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7STN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7stn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7STN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7STN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7stn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7stn OCA], [https://pdbe.org/7stn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7stn RCSB], [https://www.ebi.ac.uk/pdbsum/7stn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7stn ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=BGI:(2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]acetic+acid+(non-preferred+name)'>BGI</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chitin_synthase Chitin synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.16 2.4.1.16] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7stn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7stn OCA], [https://pdbe.org/7stn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7stn RCSB], [https://www.ebi.ac.uk/pdbsum/7stn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7stn ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chitin is an essential component of the fungal cell wall. Chitin synthases (Chss) catalyze chitin formation and translocation across the membrane and are targets of antifungal agents, including nikkomycin Z and polyoxin D. Lack of structural insights into the action of these inhibitors on Chs has hampered their further development to the clinic. We present the cryo-EM structures of Chs2 from Candida albicans (CaChs2) in the apo, substrate-bound, nikkomycin Z-bound, and polyoxin D-bound states. CaChs2 adopts a unique domain-swapped dimer configuration where a conserved motif in the domain-swapped region controls enzyme activity. CaChs2 has a dual regulation mechanism where the chitin translocation tunnel is closed by the extracellular gate and plugged by a lipid molecule in the apo state to prevent non-specific leak. Analyses of substrate and inhibitor binding provide insights into the chemical logic of Chs inhibition, which can guide Chs-targeted antifungal development.
		+
		+	Structural basis for inhibition and regulation of a chitin synthase from Candida albicans.,Ren Z, Chhetri A, Guan Z, Suo Y, Yokoyama K, Lee SY Nat Struct Mol Biol. 2022 Jul 4. pii: 10.1038/s41594-022-00791-x. doi:, 10.1038/s41594-022-00791-x. PMID:35788183<ref>PMID:35788183</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7stn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chitin synthase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chhetri A]]	+	[[Category: Chhetri, A]]
-	[[Category: Lee S]]	+	[[Category: Lee, S]]
-	[[Category: Ren Z]]	+	[[Category: Ren, Z]]
-	[[Category: Yokoyama K]]	+	[[Category: Yokoyama, K]]
		+	[[Category: Chitin synthesis]]
		+	[[Category: Glycosyltransferase]]
		+	[[Category: Membrane protein]]
		+	[[Category: Nikkomycin z]]
		+	[[Category: Transferase]]

OCA at 05:16, 13 July 2022

OCA — Wed, 13 Jul 2022 05:16:53 GMT

←Older revision		Revision as of 05:16, 13 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7stn is ~~ON HOLD until Paper Publication~~	+	==Chitin Synthase 2 from Candida albicans bound to Nikkomycin Z==
-		+	<StructureSection load='7stn' size='340' side='right'caption='[[7stn]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7STN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7STN FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7stn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7stn OCA], [https://pdbe.org/7stn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7stn RCSB], [https://www.ebi.ac.uk/pdbsum/7stn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7stn ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chhetri A]]
		+	[[Category: Lee S]]
		+	[[Category: Ren Z]]
		+	[[Category: Yokoyama K]]

OCA: Protected "7stn" [edit=sysop:move=sysop]

OCA — Wed, 24 Nov 2021 10:58:34 GMT

Protected "7stn" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:58, 24 November 2021

OCA: New page: '''Unreleased structure''' The entry 7stn is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 24 Nov 2021 10:58:33 GMT

New page: '''Unreleased structure''' The entry 7stn is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7stn is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]