OCA at 16:54, 18 October 2023

OCA — Wed, 18 Oct 2023 16:54:47 GMT

←Older revision		Revision as of 16:54, 18 October 2023
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-	====	+	==Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.106 in complex with CTLA-4==
-	<StructureSection load='7su1' size='340' side='right'caption='[[7su1]]' scene=''>	+	<StructureSection load='7su1' size='340' side='right'caption='[[7su1]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7su1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SU1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7su1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7su1 OCA], [https://pdbe.org/7su1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7su1 RCSB], [https://www.ebi.ac.uk/pdbsum/7su1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7su1 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.53Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7su1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7su1 OCA], [https://pdbe.org/7su1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7su1 RCSB], [https://www.ebi.ac.uk/pdbsum/7su1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7su1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CTLA4_HUMAN CTLA4_HUMAN] Genetic variation in CTLA4 influences susceptibility to systemic lupus erythematosus (SLE) [MIM:[https://omim.org/entry/152700 152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:10924276</ref> Note=Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.<ref>PMID:10924276</ref> Genetic variation in CTLA4 is the cause of susceptibility to diabetes mellitus insulin-dependent type 12 (IDDM12) [MIM:[https://omim.org/entry/601388 601388]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:10924276</ref> <ref>PMID:9259273</ref> Genetic variation in CTLA4 is the cause of susceptibility to celiac disease type 3 (CELIAC3) [MIM:[https://omim.org/entry/609755 609755]. It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CTLA4_HUMAN CTLA4_HUMAN] Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.<ref>PMID:1714933</ref> <ref>PMID:16551244</ref>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[CTLA-4\|CTLA-4]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Chau B]]
		+	[[Category: Lee PS]]
		+	[[Category: Strop P]]

OCA at 06:21, 2 March 2022

OCA — Wed, 02 Mar 2022 06:21:56 GMT

←Older revision		Revision as of 06:21, 2 March 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7su1 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7su1' size='340' side='right'caption='[[7su1]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7su1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7su1 OCA], [https://pdbe.org/7su1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7su1 RCSB], [https://www.ebi.ac.uk/pdbsum/7su1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7su1 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 14:01, 22 December 2021

OCA — Wed, 22 Dec 2021 14:01:47 GMT

←Older revision		Revision as of 14:01, 22 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7su1 is ON HOLD	+	The entry 7su1 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7su1" [edit=sysop:move=sysop]

OCA — Wed, 24 Nov 2021 10:59:43 GMT

Protected "7su1" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:59, 24 November 2021

OCA: New page: '''Unreleased structure''' The entry 7su1 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 24 Nov 2021 10:59:42 GMT

New page: '''Unreleased structure''' The entry 7su1 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7su1 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7su1 - Revision history

OCA at 16:54, 18 October 2023

OCA at 06:21, 2 March 2022

OCA at 14:01, 22 December 2021

OCA: Protected "7su1" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7su1 is ON HOLD Authors: Description: Category: Unreleased Structures