7sxc - Revision history

OCA at 11:20, 14 June 2023

OCA — Wed, 14 Jun 2023 11:20:56 GMT

←Older revision		Revision as of 11:20, 14 June 2023
Line 1:		Line 1:

	==cTnC-TnI chimera complexed with calcium==		==cTnC-TnI chimera complexed with calcium==
-	<StructureSection load='7sxc' size='340' side='right'caption='[[7sxc~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='7sxc' size='340' side='right'caption='[[7sxc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7sxc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SXC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7sxc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SXC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sxc OCA], [https://pdbe.org/7sxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sxc RCSB], [https://www.ebi.ac.uk/pdbsum/7sxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sxc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sxc OCA], [https://pdbe.org/7sxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sxc RCSB], [https://www.ebi.ac.uk/pdbsum/7sxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sxc ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/TNNC1_HUMAN TNNC1_HUMAN]] Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:[https://omim.org/entry/611879 611879]]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:15542288</ref> Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:[https://omim.org/entry/613243 613243]]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:11385718</ref> <ref>PMID:16302972</ref> <ref>PMID:18572189</ref> <ref>PMID:19439414</ref>	+	[https://www.uniprot.org/uniprot/TNNC1_HUMAN TNNC1_HUMAN] Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:[https://omim.org/entry/611879 611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:15542288</ref> Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:[https://omim.org/entry/613243 613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:11385718</ref> <ref>PMID:16302972</ref> <ref>PMID:18572189</ref> <ref>PMID:19439414</ref> [https://www.uniprot.org/uniprot/TNNI3_HUMAN TNNI3_HUMAN] Defects in TNNI3 are the cause of familial hypertrophic cardiomyopathy type 7 (CMH7) [MIM:[https://omim.org/entry/613690 613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:9241277</ref> <ref>PMID:11815426</ref> <ref>PMID:12707239</ref> <ref>PMID:12974739</ref> <ref>PMID:16199542</ref> Defects in TNNI3 are the cause of familial restrictive cardiomyopathy type 1 (RCM1) [MIM:[https://omim.org/entry/115210 115210]. RCM1 is a heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.<ref>PMID:12531876</ref> Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [MIM:[https://omim.org/entry/611880 611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:15070570</ref> Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [MIM:[https://omim.org/entry/613286 613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TNNC1_HUMAN TNNC1_HUMAN]] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.	+	[https://www.uniprot.org/uniprot/TNNC1_HUMAN TNNC1_HUMAN] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.[https://www.uniprot.org/uniprot/TNNI3_HUMAN TNNI3_HUMAN] Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 7sxc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7sxc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Troponin 3D structures\|Troponin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hartman~~, J J~~]]	+	[[Category: Hartman JJ]]
-	[[Category: Poppe, L]]	+	[[Category: Poppe L]]
-	[[Category: Reagan~~, J D~~]]	+	[[Category: Reagan JD]]
-	[[Category: Romero, A]]	+	[[Category: Romero A]]
-	~~[[Category: Calcium sensitizer]]~~	+
-	~~[[Category: Cardiac troponin]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 10:22, 13 April 2022

OCA — Wed, 13 Apr 2022 10:22:56 GMT

←Older revision		Revision as of 10:22, 13 April 2022
Line 1:		Line 1:

	==cTnC-TnI chimera complexed with calcium==		==cTnC-TnI chimera complexed with calcium==
-	<StructureSection load='7sxc' size='340' side='right'caption='[[7sxc]]' scene=''>	+	<StructureSection load='7sxc' size='340' side='right'caption='[[7sxc]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SXC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7sxc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SXC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sxc OCA], [https://pdbe.org/7sxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sxc RCSB], [https://www.ebi.ac.uk/pdbsum/7sxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sxc ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sxc OCA], [https://pdbe.org/7sxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sxc RCSB], [https://www.ebi.ac.uk/pdbsum/7sxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sxc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/TNNC1_HUMAN TNNC1_HUMAN]] Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:[https://omim.org/entry/611879 611879]]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:15542288</ref> Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:[https://omim.org/entry/613243 613243]]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:11385718</ref> <ref>PMID:16302972</ref> <ref>PMID:18572189</ref> <ref>PMID:19439414</ref>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/TNNC1_HUMAN TNNC1_HUMAN]] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cardiac troponin is a regulatory protein complex located on the sarcomere that regulates the engagement of myosin on actin filaments. Low-molecular weight modulators of troponin that bind allosterically with the calcium ion have the potential to improve cardiac contractility in patients with reduced cardiac function. Here we propose an approach to the rational design of troponin modulators through the combined use of solution nuclear magnetic resonance and isothermal titration calorimetry methods. In contrast to traditional approaches limited to calcium and activator-bound troponin structures, here we analyzed the structural and thermodynamic impact of an activator in the context of the troponin functional cycle. This led us to propose a rationale for developing an efficacious troponin activator.
		+
		+	Structural and Thermodynamic Model for the Activation of Cardiac Troponin.,Poppe L, Hartman JJ, Romero A, Reagan JD Biochemistry. 2022 Mar 29. doi: 10.1021/acs.biochem.2c00084. PMID:35349258<ref>PMID:35349258</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7sxc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hartman JJ]]	+	[[Category: Hartman, J J]]
-	[[Category: Poppe L]]	+	[[Category: Poppe, L]]
-	[[Category: Reagan JD]]	+	[[Category: Reagan, J D]]
-	[[Category: Romero A]]	+	[[Category: Romero, A]]
		+	[[Category: Calcium sensitizer]]
		+	[[Category: Cardiac troponin]]
		+	[[Category: Metal binding protein]]

OCA at 10:26, 6 April 2022

OCA — Wed, 06 Apr 2022 10:26:08 GMT

←Older revision		Revision as of 10:26, 6 April 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7sxc ~~is ON HOLD until Paper Publication~~	+	==cTnC-TnI chimera complexed with calcium==
-		+	<StructureSection load='7sxc' size='340' side='right'caption='[[7sxc]]' scene=''>
-	~~Authors~~: ~~Poppe~~, L., ~~Hartman~~, J.J., ~~Romero, A~~., ~~Reagan, J~~.D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SXC FirstGlance]. <br>
-	~~Description: cTnC-TnI chimera complexed with calcium~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sxc OCA], [https://pdbe.org/7sxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sxc RCSB], [https://www.ebi.ac.uk/pdbsum/7sxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sxc ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Reagan, J.D~~]]	+	__TOC__
-	[[Category: ~~Romero, A~~]]	+	</StructureSection>
-	[[Category: ~~Hartman, J.J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Poppe, L~~]]	+	[[Category: Hartman JJ]]
		+	[[Category: Poppe L]]
		+	[[Category: Reagan JD]]
		+	[[Category: Romero A]]

OCA at 08:34, 8 December 2021

OCA — Wed, 08 Dec 2021 08:34:34 GMT

←Older revision		Revision as of 08:34, 8 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7sxc is ON HOLD	+	The entry 7sxc is ON HOLD until Paper Publication

	Authors: Poppe, L., Hartman, J.J., Romero, A., Reagan, J.D.		Authors: Poppe, L., Hartman, J.J., Romero, A., Reagan, J.D.

OCA: Protected "7sxc" [edit=sysop:move=sysop]

OCA — Wed, 01 Dec 2021 05:14:02 GMT

Protected "7sxc" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:14, 1 December 2021

OCA: New page: '''Unreleased structure''' The entry 7sxc is ON HOLD Authors: Poppe, L., Hartman, J.J., Romero, A., Reagan, J.D. Description: cTnC-TnI chimera complexed with calcium [[Category: Unrele...

OCA — Wed, 01 Dec 2021 05:14:01 GMT

New page: '''Unreleased structure''' The entry 7sxc is ON HOLD Authors: Poppe, L., Hartman, J.J., Romero, A., Reagan, J.D. Description: cTnC-TnI chimera complexed with calcium [[Category: Unrele...

New page

'''Unreleased structure'''

The entry 7sxc is ON HOLD

Authors: Poppe, L., Hartman, J.J., Romero, A., Reagan, J.D.

Description: cTnC-TnI chimera complexed with calcium
[[Category: Unreleased Structures]]
[[Category: Reagan, J.D]]
[[Category: Romero, A]]
[[Category: Hartman, J.J]]
[[Category: Poppe, L]]