7szl - Revision history

OCA at 16:56, 18 October 2023

OCA — Wed, 18 Oct 2023 16:56:20 GMT

←Older revision		Revision as of 16:56, 18 October 2023
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	<StructureSection load='7szl' size='340' side='right'caption='[[7szl]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='7szl' size='340' side='right'caption='[[7szl]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7szl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7szl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SZL FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>~~[https://en.wikipedia.org/wiki/ADP~~-~~ribosyl_cyclase/cyclic_ADP-ribose_hydrolase ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.~~2.~~2.6~~ 3~~.2.2.6] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7szl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7szl OCA], [https://pdbe.org/7szl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7szl RCSB], [https://www.ebi.ac.uk/pdbsum/7szl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7szl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7szl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7szl OCA], [https://pdbe.org/7szl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7szl RCSB], [https://www.ebi.ac.uk/pdbsum/7szl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7szl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IRPL2_HUMAN IRPL2_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gu, W]]	+	[[Category: Gu W]]
-	[[Category: Kobe, B]]	+	[[Category: Kobe B]]
-	[[Category: Manik~~, M K~~]]	+	[[Category: Manik MK]]
-	[[Category: Nanson~~, J D~~]]	+	[[Category: Nanson JD]]
-	[[Category: Nimma, S]]	+	[[Category: Nimma S]]
-	[[Category: Ve, T]]	+	[[Category: Ve T]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Interleukin-1 receptor]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Tir domain~~]]	+

OCA at 03:09, 21 April 2022

OCA — Thu, 21 Apr 2022 03:09:56 GMT

←Older revision		Revision as of 03:09, 21 April 2022
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	==Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1R10 (IL-1RAPL2)==		==Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1R10 (IL-1RAPL2)==
-	<StructureSection load='7szl' size='340' side='right'caption='[[7szl]]' scene=''>	+	<StructureSection load='7szl' size='340' side='right'caption='[[7szl]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7szl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SZL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7szl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7szl OCA], [https://pdbe.org/7szl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7szl RCSB], [https://www.ebi.ac.uk/pdbsum/7szl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7szl ProSAT]</span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ADP-ribosyl_cyclase/cyclic_ADP-ribose_hydrolase ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.6 3.2.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7szl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7szl OCA], [https://pdbe.org/7szl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7szl RCSB], [https://www.ebi.ac.uk/pdbsum/7szl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7szl ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Toll/interleukin-1 receptor (TIR) domains are key innate immune signaling modules. Here, we present the crystal structure of the TIR domain of human Interleukin-1 receptor 10 (IL-1R10), also called IL-1RAPL2. It is similar to that of IL-1R9 (IL-1RAPL1) but shows significant structural differences to those from Toll-like receptors (TLRs) and the adaptor proteins MAL and MyD88. Interactions of TIR domains in their respective crystals and the higher-order assemblies (MAL and MyD88) reveal the presence of a common 'BCD surface', suggesting its functional significance. We also show that the TIR domains of IL-1R10 and IL-1R9 lack NADase activity, consistent with their structures. Our study provides a foundation for unraveling the functions of IL-1R9 and IL-1R10.
		+
		+	Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of IL-1R10 provides structural insights into TIR domain signaling.,Nimma S, Gu W, Manik MK, Ve T, Nanson JD, Kobe B FEBS Lett. 2022 Jan 17. doi: 10.1002/1873-3468.14288. PMID:35038778<ref>PMID:35038778</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7szl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gu W]]	+	[[Category: Gu, W]]
-	[[Category: Kobe B]]	+	[[Category: Kobe, B]]
-	[[Category: Manik MK]]	+	[[Category: Manik, M K]]
-	[[Category: Nanson JD]]	+	[[Category: Nanson, J D]]
-	[[Category: Nimma S]]	+	[[Category: Nimma, S]]
-	[[Category: Ve T]]	+	[[Category: Ve, T]]
		+	[[Category: Immune system]]
		+	[[Category: Interleukin-1 receptor]]
		+	[[Category: Membrane protein]]
		+	[[Category: Tir domain]]

OCA at 07:03, 2 February 2022

OCA — Wed, 02 Feb 2022 07:03:52 GMT

←Older revision		Revision as of 07:03, 2 February 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7szl is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1R10 (IL-1RAPL2)==
-		+	<StructureSection load='7szl' size='340' side='right'caption='[[7szl]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SZL FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7szl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7szl OCA], [https://pdbe.org/7szl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7szl RCSB], [https://www.ebi.ac.uk/pdbsum/7szl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7szl ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Gu W]]
		+	[[Category: Kobe B]]
		+	[[Category: Manik MK]]
		+	[[Category: Nanson JD]]
		+	[[Category: Nimma S]]
		+	[[Category: Ve T]]

OCA at 14:02, 22 December 2021

OCA — Wed, 22 Dec 2021 14:02:46 GMT

←Older revision		Revision as of 14:02, 22 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7szl is ON HOLD	+	The entry 7szl is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7szl" [edit=sysop:move=sysop]

OCA — Wed, 08 Dec 2021 08:35:39 GMT

Protected "7szl" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:35, 8 December 2021

OCA: New page: '''Unreleased structure''' The entry 7szl is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Dec 2021 08:35:38 GMT

New page: '''Unreleased structure''' The entry 7szl is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7szl is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]