OCA at 16:56, 18 October 2023

OCA — Wed, 18 Oct 2023 16:56:45 GMT

←Older revision		Revision as of 16:56, 18 October 2023
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-	====	+	==Crystal structure of S25-39 Fab Unliganded 1==
-	<StructureSection load='7t0g' size='340' side='right'caption='[[7t0g]]' scene=''>	+	<StructureSection load='7t0g' size='340' side='right'caption='[[7t0g]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7t0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T0G FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0g OCA], [https://pdbe.org/7t0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0g RCSB], [https://www.ebi.ac.uk/pdbsum/7t0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0g ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.53Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0g OCA], [https://pdbe.org/7t0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0g RCSB], [https://www.ebi.ac.uk/pdbsum/7t0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0g ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Conformational flexibility in antibody-combining sites has been hypothesized to facilitate polyspecificity toward multiple unique epitopes and enable the limited germline repertoire to match an overwhelming diversity of potential antigens; however, elucidating the mechanisms of antigen recognition by flexible antibodies has been understandably challenging. Here, multiple liganded and unliganded crystal structures of the near-germline anticarbohydrate antibodies S25-2 and S25-39 are reported, which reveal an unprecedented diversity of complementarity-determining region H3 conformations in apparent equilibrium. These structures demonstrate that at least some germline or near-germline antibodies are flexible entities sensitive to their chemical environments, with conformational selection available as an evolved mechanism that preserves the inherited ability to recognize common pathogens while remaining adaptable to new threats.
		+
		+	Antigen binding by conformational selection in near-germline antibodies.,Blackler RJ, Muller-Loennies S, Pokorny-Lehrer B, Legg MSG, Brade L, Brade H, Kosma P, Evans SV J Biol Chem. 2022 May;298(5):101901. doi: 10.1016/j.jbc.2022.101901. Epub 2022 , Apr 6. PMID:35395245<ref>PMID:35395245</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7t0g" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Blackler RJ]]
		+	[[Category: Evans SV]]
		+	[[Category: Legg MSG]]

OCA at 02:56, 21 April 2022

OCA — Thu, 21 Apr 2022 02:56:25 GMT

←Older revision		Revision as of 02:56, 21 April 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7t0g ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7t0g' size='340' side='right'caption='[[7t0g]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0g OCA], [https://pdbe.org/7t0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0g RCSB], [https://www.ebi.ac.uk/pdbsum/7t0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0g ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 14:02, 22 December 2021

OCA — Wed, 22 Dec 2021 14:02:51 GMT

←Older revision		Revision as of 14:02, 22 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7t0g is ON HOLD	+	The entry 7t0g is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7t0g" [edit=sysop:move=sysop]

OCA — Wed, 08 Dec 2021 08:37:06 GMT

Protected "7t0g" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:37, 8 December 2021

OCA: New page: '''Unreleased structure''' The entry 7t0g is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Dec 2021 08:37:05 GMT

New page: '''Unreleased structure''' The entry 7t0g is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7t0g is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7t0g - Revision history

OCA at 16:56, 18 October 2023

OCA at 02:56, 21 April 2022

OCA at 14:02, 22 December 2021

OCA: Protected "7t0g" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7t0g is ON HOLD Authors: Description: Category: Unreleased Structures