7t0s - Revision history

OCA at 09:41, 25 October 2023

OCA — Wed, 25 Oct 2023 09:41:57 GMT

←Older revision		Revision as of 09:41, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7t0s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T0S FirstGlance]. <br>		<table><tr><td colspan='2'>[[7t0s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T0S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=E2E:3-chloro-5-{1-[2-({5-chloro-2-[(3S)-3-methylmorpholin-4-yl]pyridin-4-yl}amino)-2-oxoethyl]-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-hydroxybenzamide'>E2E</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=E2E:3-chloro-5-{1-[2-({5-chloro-2-[(3S)-3-methylmorpholin-4-yl]pyridin-4-yl}amino)-2-oxoethyl]-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-hydroxybenzamide'>E2E</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0s OCA], [https://pdbe.org/7t0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0s RCSB], [https://www.ebi.ac.uk/pdbsum/7t0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0s OCA], [https://pdbe.org/7t0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0s RCSB], [https://www.ebi.ac.uk/pdbsum/7t0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0s ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:00, 14 December 2022

OCA — Wed, 14 Dec 2022 10:00:39 GMT

←Older revision		Revision as of 10:00, 14 December 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7t0s is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the BCL6 BTB domain in complex with OICR-11864==
-		+	<StructureSection load='7t0s' size='340' side='right'caption='[[7t0s]], [[Resolution\|resolution]] 1.86Å' scene=''>
-	~~Authors~~: ~~Kuntz~~, D.A., ~~Prive~~, G.G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7t0s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T0S FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of the~~ BCL6 ~~BTB domain in complex~~ with ~~OICR~~-~~11864~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=E2E:3-chloro-5-{1-[2-({5-chloro-2-[(3S)-3-methylmorpholin-4-yl]pyridin-4-yl}amino)-2-oxoethyl]-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-hydroxybenzamide'>E2E</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0s OCA], [https://pdbe.org/7t0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0s RCSB], [https://www.ebi.ac.uk/pdbsum/7t0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0s ProSAT]</span></td></tr>
-	[[Category: ~~Prive, G.G~~]]	+	</table>
-	[[Category: Kuntz~~, D.A~~]]	+	== Disease ==
		+	[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Kuntz DA]]
		+	[[Category: Prive GG]]

OCA: Protected "7t0s" [edit=sysop:move=sysop]

OCA — Wed, 08 Dec 2021 08:37:51 GMT

Protected "7t0s" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:37, 8 December 2021

OCA: New page: '''Unreleased structure''' The entry 7t0s is ON HOLD until Paper Publication Authors: Kuntz, D.A., Prive, G.G. Description: Crystal structure of the BCL6 BTB domain in complex with OIC...

OCA — Wed, 08 Dec 2021 08:37:50 GMT

New page: '''Unreleased structure''' The entry 7t0s is ON HOLD until Paper Publication Authors: Kuntz, D.A., Prive, G.G. Description: Crystal structure of the BCL6 BTB domain in complex with OIC...

New page

'''Unreleased structure'''

The entry 7t0s is ON HOLD until Paper Publication

Authors: Kuntz, D.A., Prive, G.G.

Description: Crystal structure of the BCL6 BTB domain in complex with OICR-11864
[[Category: Unreleased Structures]]
[[Category: Prive, G.G]]
[[Category: Kuntz, D.A]]