OCA at 10:05, 24 November 2022

OCA — Thu, 24 Nov 2022 10:05:25 GMT

←Older revision		Revision as of 10:05, 24 November 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7t17 is ~~ON HOLD until Paper Publication~~	+	==Zika Virus asymmetric unit bound with IgM antibody DH1017 Fab fragment==
-		+	<StructureSection load='7t17' size='340' side='right'caption='[[7t17]], [[Resolution\|resolution]] 5.26Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7t17]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T17 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t17 OCA], [https://pdbe.org/7t17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t17 RCSB], [https://www.ebi.ac.uk/pdbsum/7t17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t17 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGG1_HUMAN IGG1_HUMAN] Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Zika virus]]
		+	[[Category: Kuhn RJ]]
		+	[[Category: Miller AS]]

OCA at 15:40, 15 December 2021

OCA — Wed, 15 Dec 2021 15:40:55 GMT

←Older revision		Revision as of 15:40, 15 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7t17 is ON HOLD	+	The entry 7t17 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7t17" [edit=sysop:move=sysop]

OCA — Wed, 08 Dec 2021 08:38:35 GMT

Protected "7t17" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:38, 8 December 2021

OCA: New page: '''Unreleased structure''' The entry 7t17 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Dec 2021 08:38:34 GMT

New page: '''Unreleased structure''' The entry 7t17 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7t17 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7t17 - Revision history

OCA at 10:05, 24 November 2022

OCA at 15:40, 15 December 2021

OCA: Protected "7t17" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7t17 is ON HOLD Authors: Description: Category: Unreleased Structures