7t4u - Revision history

OCA at 07:31, 12 July 2023

OCA — Wed, 12 Jul 2023 07:31:02 GMT

←Older revision		Revision as of 07:31, 12 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7t4u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T4U FirstGlance]. <br>		<table><tr><td colspan='2'>[[7t4u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T4U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EX6:3-amino-4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)benzoic+acid'>EX6</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.99Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EX6:3-amino-4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)benzoic+acid'>EX6</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t4u OCA], [https://pdbe.org/7t4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t4u RCSB], [https://www.ebi.ac.uk/pdbsum/7t4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t4u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t4u OCA], [https://pdbe.org/7t4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t4u RCSB], [https://www.ebi.ac.uk/pdbsum/7t4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t4u ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:10, 14 June 2023

OCA — Wed, 14 Jun 2023 08:10:15 GMT

←Older revision		Revision as of 08:10, 14 June 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7t4u is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of cGMP-dependent Protein Kinase==
-		+	<StructureSection load='7t4u' size='340' side='right'caption='[[7t4u]], [[Resolution\|resolution]] 1.99Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7t4u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T4U FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EX6:3-amino-4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)benzoic+acid'>EX6</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t4u OCA], [https://pdbe.org/7t4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t4u RCSB], [https://www.ebi.ac.uk/pdbsum/7t4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t4u ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KGP1_HUMAN KGP1_HUMAN] Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates MRVI1/IRAG and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle.<ref>PMID:8182057</ref> <ref>PMID:10567269</ref> <ref>PMID:11162591</ref> <ref>PMID:12082086</ref> <ref>PMID:11723116</ref> <ref>PMID:14608379</ref> <ref>PMID:15194681</ref> <ref>PMID:16990611</ref> <ref>PMID:21402151</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Fischmann TO]]
		+	[[Category: Silvestre L]]
		+	[[Category: Zebisch M]]

OCA at 05:55, 19 January 2022

OCA — Wed, 19 Jan 2022 05:55:14 GMT

←Older revision		Revision as of 05:55, 19 January 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7t4u is ON HOLD	+	The entry 7t4u is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7t4u" [edit=sysop:move=sysop]

OCA — Wed, 22 Dec 2021 14:04:10 GMT

Protected "7t4u" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:04, 22 December 2021

OCA: New page: '''Unreleased structure''' The entry 7t4u is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Dec 2021 14:04:09 GMT

New page: '''Unreleased structure''' The entry 7t4u is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7t4u is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]