7t5y - Revision history

OCA at 17:00, 18 October 2023

OCA — Wed, 18 Oct 2023 17:00:43 GMT

←Older revision		Revision as of 17:00, 18 October 2023
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	<StructureSection load='7t5y' size='340' side='right'caption='[[7t5y]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='7t5y' size='340' side='right'caption='[[7t5y]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7t5y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T5Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7t5y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T5Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F2D:3-methyl-2-[(2E)-non-2-en-1-yl]quinolin-4(1H)-one'>F2D</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.62Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7t5k\|7t5k]], [[7t6c\|7t6c]], [[7t6h\|7t6h]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F2D:3-methyl-2-[(2E)-non-2-en-1-yl]quinolin-4(1H)-one'>F2D</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5y OCA], [https://pdbe.org/7t5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5y RCSB], [https://www.ebi.ac.uk/pdbsum/7t5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5y OCA], [https://pdbe.org/7t5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5y RCSB], [https://www.ebi.ac.uk/pdbsum/7t5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PYRD_ECOLI PYRD_ECOLI]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.<ref>PMID:10074342</ref>	+	[https://www.uniprot.org/uniprot/PYRD_ECOLI PYRD_ECOLI] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.<ref>PMID:10074342</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7t5y" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7t5y" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dihydroorotate dehydrogenase 3D structures\|Dihydroorotate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ambarian~~, J A~~]]	+	[[Category: Ambarian JA]]
-	[[Category: Davis~~, K M~~]]	+	[[Category: Davis KM]]
-	[[Category: Horwitz~~, S M]]~~	+	[[Category: Horwitz SM]]
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]	+

OCA at 07:34, 29 June 2022

OCA — Wed, 29 Jun 2022 07:34:30 GMT

←Older revision		Revision as of 07:34, 29 June 2022
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	==E. coli dihydroorotate dehydrogenase bound to the inhibitor HMNQ==		==E. coli dihydroorotate dehydrogenase bound to the inhibitor HMNQ==
-	<StructureSection load='7t5y' size='340' side='right'caption='[[7t5y]]' scene=''>	+	<StructureSection load='7t5y' size='340' side='right'caption='[[7t5y]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T5Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7t5y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T5Y FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5y OCA], [https://pdbe.org/7t5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5y RCSB], [https://www.ebi.ac.uk/pdbsum/7t5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5y ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F2D:3-methyl-2-[(2E)-non-2-en-1-yl]quinolin-4(1H)-one'>F2D</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7t5k\|7t5k]], [[7t6c\|7t6c]], [[7t6h\|7t6h]]</div></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5y OCA], [https://pdbe.org/7t5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5y RCSB], [https://www.ebi.ac.uk/pdbsum/7t5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5y ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/PYRD_ECOLI PYRD_ECOLI]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.<ref>PMID:10074342</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hydroxyalkylquinolines (HAQs) are ubiquitious natural products but their interactions with associated protein targets remain elusive. We report X-ray crystal structures of two HAQs in complex with dihydroorotate dehydrogenase (DHODH). Our results reveal the structural basis of DHODH inhibition by HAQs and open the door to downstream structure-activity relationship studies.
		+
		+	Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines.,Horwitz SM, Blue TC, Ambarian JA, Hoshino S, Seyedsayamdost MR, Davis KM RSC Chem Biol. 2022 Feb 7;3(4):420-425. doi: 10.1039/d1cb00255d. eCollection 2022, Apr 6. PMID:35441142<ref>PMID:35441142</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7t5y" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ambarian JA]]	+	[[Category: Ambarian, J A]]
-	[[Category: Davis KM]]	+	[[Category: Davis, K M]]
-	[[Category: Horwitz SM]]	+	[[Category: Horwitz, S M]]
		+	[[Category: Inhibitor]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 06:22, 2 March 2022

OCA — Wed, 02 Mar 2022 06:22:19 GMT

←Older revision		Revision as of 06:22, 2 March 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7t5y is ~~ON HOLD until Paper Publication~~	+	==E. coli dihydroorotate dehydrogenase bound to the inhibitor HMNQ==
-		+	<StructureSection load='7t5y' size='340' side='right'caption='[[7t5y]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T5Y FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5y OCA], [https://pdbe.org/7t5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5y RCSB], [https://www.ebi.ac.uk/pdbsum/7t5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5y ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ambarian JA]]
		+	[[Category: Davis KM]]
		+	[[Category: Horwitz SM]]

OCA at 06:15, 9 February 2022

OCA — Wed, 09 Feb 2022 06:15:27 GMT

←Older revision		Revision as of 06:15, 9 February 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7t5y is ON HOLD	+	The entry 7t5y is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7t5y" [edit=sysop:move=sysop]

OCA — Wed, 22 Dec 2021 14:06:08 GMT

Protected "7t5y" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:06, 22 December 2021

OCA: New page: '''Unreleased structure''' The entry 7t5y is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Dec 2021 14:06:06 GMT

New page: '''Unreleased structure''' The entry 7t5y is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7t5y is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]