7t72 - Revision history

OCA at 07:21, 3 April 2024

OCA — Wed, 03 Apr 2024 07:21:35 GMT

←Older revision		Revision as of 07:21, 3 April 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7t72]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T72 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7t72]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T72 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.177Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t72 OCA], [https://pdbe.org/7t72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t72 RCSB], [https://www.ebi.ac.uk/pdbsum/7t72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t72 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t72 OCA], [https://pdbe.org/7t72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t72 RCSB], [https://www.ebi.ac.uk/pdbsum/7t72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t72 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:21, 21 December 2022

OCA — Wed, 21 Dec 2022 09:21:03 GMT

←Older revision		Revision as of 09:21, 21 December 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7t72 is ~~ON HOLD until Paper Publication~~	+	==Epitope-based selection of SARS-CoV-2 neutralizing antibodies from convalescent patients==
-		+	<StructureSection load='7t72' size='340' side='right'caption='[[7t72]], [[Resolution\|resolution]] 3.18Å' scene=''>
-	~~Authors~~: ~~Langley~~, D.B., ~~Christ~~, D., ~~Rouet~~, R.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7t72]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T72 FirstGlance]. <br>
-	~~Description~~: ~~Epitope~~-~~based selection~~ of ~~SARS~~-~~CoV~~-~~2 neutralizing antibodies from convalescent patients~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t72 OCA], [https://pdbe.org/7t72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t72 RCSB], [https://www.ebi.ac.uk/pdbsum/7t72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t72 ProSAT]</span></td></tr>
-	[[Category: ~~Langley, D.B~~]]	+	</table>
-	[[Category: ~~Rouet, R~~]]	+	== Function ==
-	[[Category: Christ, D]]	+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Christ D]]
		+	[[Category: Langley DB]]
		+	[[Category: Rouet R]]

OCA at 05:56, 19 January 2022

OCA — Wed, 19 Jan 2022 05:56:40 GMT

←Older revision		Revision as of 05:56, 19 January 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7t72 is ON HOLD	+	The entry 7t72 is ON HOLD until Paper Publication

	Authors: Langley, D.B., Christ, D., Rouet, R.		Authors: Langley, D.B., Christ, D., Rouet, R.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Langley, D.B]]		[[Category: Langley, D.B]]
-	[[Category: Christ, D]]
	[[Category: Rouet, R]]		[[Category: Rouet, R]]
		+	[[Category: Christ, D]]

OCA: Protected "7t72" [edit=sysop:move=sysop]

OCA — Wed, 22 Dec 2021 14:07:44 GMT

Protected "7t72" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:07, 22 December 2021

OCA: New page: '''Unreleased structure''' The entry 7t72 is ON HOLD Authors: Langley, D.B., Christ, D., Rouet, R. Description: Epitope-based selection of SARS-CoV-2 neutralizing antibodies from conva...

OCA — Wed, 22 Dec 2021 14:07:43 GMT

New page: '''Unreleased structure''' The entry 7t72 is ON HOLD Authors: Langley, D.B., Christ, D., Rouet, R. Description: Epitope-based selection of SARS-CoV-2 neutralizing antibodies from conva...

New page

'''Unreleased structure'''

The entry 7t72 is ON HOLD

Authors: Langley, D.B., Christ, D., Rouet, R.

Description: Epitope-based selection of SARS-CoV-2 neutralizing antibodies from convalescent patients
[[Category: Unreleased Structures]]
[[Category: Langley, D.B]]
[[Category: Christ, D]]
[[Category: Rouet, R]]