7t7a - Revision history

OCA at 10:43, 22 May 2024

OCA — Wed, 22 May 2024 10:43:26 GMT

←Older revision		Revision as of 10:43, 22 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7t7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7A FirstGlance]. <br>		<table><tr><td colspan='2'>[[7t7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.79Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7a OCA], [https://pdbe.org/7t7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7a RCSB], [https://www.ebi.ac.uk/pdbsum/7t7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7a OCA], [https://pdbe.org/7t7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7a RCSB], [https://www.ebi.ac.uk/pdbsum/7t7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7a ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Noonan syndrome-like disorder with loose anagen hair. The disease is caused by variants affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN] Noonan syndrome-like disorder with loose anagen hair. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.<ref>PMID:10783161</ref> <ref>PMID:16630891</ref> <ref>PMID:25137548</ref>	+	[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN] Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.<ref>PMID:10783161</ref> <ref>PMID:16630891</ref> <ref>PMID:25137548</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	Receptor tyrosine kinase (RTK)-RAS signalling through the downstream mitogen-activated protein kinase (MAPK) cascade regulates cell proliferation and survival. The SHOC2-MRAS-PP1C holophosphatase complex functions as a key regulator of RTK-RAS signalling by removing an inhibitory phosphorylation event on the RAF family of proteins to potentiate MAPK signalling(1). SHOC2 forms a ternary complex with MRAS and PP1C, and human germline gain-of-function mutations in this complex result in congenital RASopathy syndromes(2-5). However, the structure and assembly of this complex are poorly understood. Here we use cryo-electron microscopy to resolve the structure of the SHOC2-MRAS-PP1C complex. We define the biophysical principles of holoenzyme interactions, elucidate the assembly order of the complex, and systematically interrogate the functional consequence of nearly all of the possible missense variants of SHOC2 through deep mutational scanning. We show that SHOC2 binds PP1C and MRAS through the concave surface of the leucine-rich repeat region and further engages PP1C through the N-terminal disordered region that contains a cryptic RVXF motif. Complex formation is initially mediated by interactions between SHOC2 and PP1C and is stabilized by the binding of GTP-loaded MRAS. These observations explain how mutant versions of SHOC2 in RASopathies and cancer stabilize the interactions of complex members to enhance holophosphatase activity. Together, this integrative structure-function model comprehensively defines key binding interactions within the SHOC2-MRAS-PP1C holophosphatase complex and will inform therapeutic development .		Receptor tyrosine kinase (RTK)-RAS signalling through the downstream mitogen-activated protein kinase (MAPK) cascade regulates cell proliferation and survival. The SHOC2-MRAS-PP1C holophosphatase complex functions as a key regulator of RTK-RAS signalling by removing an inhibitory phosphorylation event on the RAF family of proteins to potentiate MAPK signalling(1). SHOC2 forms a ternary complex with MRAS and PP1C, and human germline gain-of-function mutations in this complex result in congenital RASopathy syndromes(2-5). However, the structure and assembly of this complex are poorly understood. Here we use cryo-electron microscopy to resolve the structure of the SHOC2-MRAS-PP1C complex. We define the biophysical principles of holoenzyme interactions, elucidate the assembly order of the complex, and systematically interrogate the functional consequence of nearly all of the possible missense variants of SHOC2 through deep mutational scanning. We show that SHOC2 binds PP1C and MRAS through the concave surface of the leucine-rich repeat region and further engages PP1C through the N-terminal disordered region that contains a cryptic RVXF motif. Complex formation is initially mediated by interactions between SHOC2 and PP1C and is stabilized by the binding of GTP-loaded MRAS. These observations explain how mutant versions of SHOC2 in RASopathies and cancer stabilize the interactions of complex members to enhance holophosphatase activity. Together, this integrative structure-function model comprehensively defines key binding interactions within the SHOC2-MRAS-PP1C holophosphatase complex and will inform therapeutic development .

-	Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.,Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ Nature. 2022 ~~Jul 13. pii~~: ~~10.1038/s41586~~-~~022-04928-2~~. doi:, 10.1038/s41586-022-04928-2. PMID:35831509<ref>PMID:35831509</ref>	+	Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.,Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ Nature. 2022 Sep;609(7926):408-415. doi: 10.1038/s41586-022-04928-2. Epub 2022 , Jul 13. PMID:35831509<ref>PMID:35831509</ref>

	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

OCA at 07:54, 21 September 2022

OCA — Wed, 21 Sep 2022 07:54:50 GMT

←Older revision		Revision as of 07:54, 21 September 2022
Line 3:		Line 3:
	<StructureSection load='7t7a' size='340' side='right'caption='[[7t7a]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='7t7a' size='340' side='right'caption='[[7t7a]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7t7a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7t7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7a OCA], [https://pdbe.org/7t7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7a RCSB], [https://www.ebi.ac.uk/pdbsum/7t7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7a OCA], [https://pdbe.org/7t7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7a RCSB], [https://www.ebi.ac.uk/pdbsum/7t7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7a ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Noonan syndrome-like disorder with loose anagen hair. The disease is caused by variants affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Noonan syndrome-like disorder with loose anagen hair. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.<ref>PMID:10783161</ref> <ref>PMID:16630891</ref> <ref>PMID:25137548</ref>	+	[[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.<ref>PMID:10783161</ref> <ref>PMID:16630891</ref> <ref>PMID:25137548</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aguirre, J]]	+	[[Category: Aguirre J]]
-	[[Category: Bian, Y]]	+	[[Category: Bian Y]]
-	[[Category: Fuller, C]]	+	[[Category: Fuller C]]
-	[[Category: Hajian, B]]	+	[[Category: Hajian B]]
-	[[Category: Kwon, J]]	+	[[Category: Kwon J]]
-	[[Category: Lemke, C]]	+	[[Category: Lemke C]]
-	~~[[Category: Leucine-rich]]~~	+
-	~~[[Category: Scaffold]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 06:41, 18 August 2022

OCA — Thu, 18 Aug 2022 06:41:52 GMT

←Older revision		Revision as of 06:41, 18 August 2022
Line 1:		Line 1:

	==Crystal Structure of Human SHOC2: A Leucine-Rich Repeat Protein==		==Crystal Structure of Human SHOC2: A Leucine-Rich Repeat Protein==
-	<StructureSection load='7t7a' size='340' side='right'caption='[[7t7a]]' scene=''>	+	<StructureSection load='7t7a' size='340' side='right'caption='[[7t7a]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7t7a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7A FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7a OCA], [https://pdbe.org/7t7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7a RCSB], [https://www.ebi.ac.uk/pdbsum/7t7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7a ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7a OCA], [https://pdbe.org/7t7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7a RCSB], [https://www.ebi.ac.uk/pdbsum/7t7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7a ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Noonan syndrome-like disorder with loose anagen hair. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.<ref>PMID:10783161</ref> <ref>PMID:16630891</ref> <ref>PMID:25137548</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Receptor tyrosine kinase (RTK)-RAS signalling through the downstream mitogen-activated protein kinase (MAPK) cascade regulates cell proliferation and survival. The SHOC2-MRAS-PP1C holophosphatase complex functions as a key regulator of RTK-RAS signalling by removing an inhibitory phosphorylation event on the RAF family of proteins to potentiate MAPK signalling(1). SHOC2 forms a ternary complex with MRAS and PP1C, and human germline gain-of-function mutations in this complex result in congenital RASopathy syndromes(2-5). However, the structure and assembly of this complex are poorly understood. Here we use cryo-electron microscopy to resolve the structure of the SHOC2-MRAS-PP1C complex. We define the biophysical principles of holoenzyme interactions, elucidate the assembly order of the complex, and systematically interrogate the functional consequence of nearly all of the possible missense variants of SHOC2 through deep mutational scanning. We show that SHOC2 binds PP1C and MRAS through the concave surface of the leucine-rich repeat region and further engages PP1C through the N-terminal disordered region that contains a cryptic RVXF motif. Complex formation is initially mediated by interactions between SHOC2 and PP1C and is stabilized by the binding of GTP-loaded MRAS. These observations explain how mutant versions of SHOC2 in RASopathies and cancer stabilize the interactions of complex members to enhance holophosphatase activity. Together, this integrative structure-function model comprehensively defines key binding interactions within the SHOC2-MRAS-PP1C holophosphatase complex and will inform therapeutic development .
		+
		+	Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.,Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ Nature. 2022 Jul 13. pii: 10.1038/s41586-022-04928-2. doi:, 10.1038/s41586-022-04928-2. PMID:35831509<ref>PMID:35831509</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7t7a" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aguirre J]]	+	[[Category: Aguirre, J]]
-	[[Category: Bian Y]]	+	[[Category: Bian, Y]]
-	[[Category: Fuller C]]	+	[[Category: Fuller, C]]
-	[[Category: Hajian B]]	+	[[Category: Hajian, B]]
-	[[Category: Kwon J]]	+	[[Category: Kwon, J]]
-	[[Category: Lemke C]]	+	[[Category: Lemke, C]]
		+	[[Category: Leucine-rich]]
		+	[[Category: Scaffold]]
		+	[[Category: Structural protein]]

OCA at 12:51, 4 May 2022

OCA — Wed, 04 May 2022 12:51:10 GMT

←Older revision		Revision as of 12:51, 4 May 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7t7a is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of Human SHOC2: A Leucine-Rich Repeat Protein==
-		+	<StructureSection load='7t7a' size='340' side='right'caption='[[7t7a]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7A FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7a OCA], [https://pdbe.org/7t7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7a RCSB], [https://www.ebi.ac.uk/pdbsum/7t7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7a ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Aguirre J]]
		+	[[Category: Bian Y]]
		+	[[Category: Fuller C]]
		+	[[Category: Hajian B]]
		+	[[Category: Kwon J]]
		+	[[Category: Lemke C]]

OCA at 05:56, 19 January 2022

OCA — Wed, 19 Jan 2022 05:56:57 GMT

←Older revision		Revision as of 05:56, 19 January 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7t7a is ON HOLD	+	The entry 7t7a is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7t7a" [edit=sysop:move=sysop]

OCA — Wed, 22 Dec 2021 14:08:09 GMT

Protected "7t7a" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:08, 22 December 2021

OCA: New page: '''Unreleased structure''' The entry 7t7a is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Dec 2021 14:08:08 GMT

New page: '''Unreleased structure''' The entry 7t7a is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7t7a is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]