7t8j - Revision history

OCA at 09:44, 25 October 2023

OCA — Wed, 25 Oct 2023 09:44:19 GMT

←Older revision		Revision as of 09:44, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7t8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T8J FirstGlance]. <br>		<table><tr><td colspan='2'>[[7t8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T8J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.89Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t8j OCA], [https://pdbe.org/7t8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t8j RCSB], [https://www.ebi.ac.uk/pdbsum/7t8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t8j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t8j OCA], [https://pdbe.org/7t8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t8j RCSB], [https://www.ebi.ac.uk/pdbsum/7t8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t8j ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:21, 21 December 2022

OCA — Wed, 21 Dec 2022 09:21:11 GMT

←Older revision		Revision as of 09:21, 21 December 2022
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-	'''Unreleased structure'''

-	The ~~entry~~ 7t8j is ~~ON HOLD until Paper Publication~~	+	==The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL crystallization chaperone via a 4-glycine linker==
-		+	<StructureSection load='7t8j' size='340' side='right'caption='[[7t8j]], [[Resolution\|resolution]] 1.89Å' scene=''>
-	~~Authors~~: ~~Soleimani, S~~., ~~Pedroza Romo, M~~.J., ~~Smith, T~~., ~~Brown, S~~., ~~Doukov, T~~., ~~Moody, J~~.D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7t8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T8J FirstGlance]. <br>
-	~~Description~~: ~~The ubiquitin-associated domain~~ of ~~human thirty-eight negative kinase~~-1 ~~flexibly fused~~ to the ~~1TEL crystallization chaperone via~~ a 4-~~glycine linker~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t8j OCA], [https://pdbe.org/7t8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t8j RCSB], [https://www.ebi.ac.uk/pdbsum/7t8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t8j ProSAT]</span></td></tr>
-	[[Category: ~~Pedroza Romo, M.J~~]]	+	</table>
-	[[Category: ~~Moody, J.D~~]]	+	== Disease ==
-	[[Category: Doukov, T]]	+	[https://www.uniprot.org/uniprot/ETV6_HUMAN ETV6_HUMAN] Note=A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).<ref>PMID:12203785</ref> Note=Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2.<ref>PMID:7761424</ref> <ref>PMID:7780150</ref> <ref>PMID:15806161</ref> Note=Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1. Note=A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2. Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6. Note=A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6. Note=A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2. Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE) [MIM:[https://omim.org/entry/131440 131440]. A hematologic disorder characterized by malignant eosinophils proliferation. Note=A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein. Defects in ETV6 are a cause of acute myelogenous leukemia (AML) [MIM:[https://omim.org/entry/601626 601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.<ref>PMID:7761424</ref> <ref>PMID:7780150</ref> <ref>PMID:15806161</ref> Note=A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5.
-	[[Category: ~~Smith, T~~]]	+	== Function ==
-	[[Category: ~~Brown, S~~]]	+	[https://www.uniprot.org/uniprot/ETV6_HUMAN ETV6_HUMAN] Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.[https://www.uniprot.org/uniprot/TNK1_HUMAN TNK1_HUMAN] Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.<ref>PMID:10873601</ref> <ref>PMID:18974114</ref>
-	[[Category: Soleimani, S]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Brown S]]
		+	[[Category: Doukov T]]
		+	[[Category: Moody JD]]
		+	[[Category: Pedroza Romo MJ]]
		+	[[Category: Smith T]]
		+	[[Category: Soleimani S]]

OCA at 06:38, 22 June 2022

OCA — Wed, 22 Jun 2022 06:38:25 GMT

←Older revision		Revision as of 06:38, 22 June 2022
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	[[Category: Pedroza Romo, M.J]]		[[Category: Pedroza Romo, M.J]]
	[[Category: Moody, J.D]]		[[Category: Moody, J.D]]
-	[[Category: Soleimani, S]]
	[[Category: Doukov, T]]		[[Category: Doukov, T]]
	[[Category: Smith, T]]		[[Category: Smith, T]]
	[[Category: Brown, S]]		[[Category: Brown, S]]
		+	[[Category: Soleimani, S]]

OCA at 09:19, 5 January 2022

OCA — Wed, 05 Jan 2022 09:19:52 GMT

←Older revision		Revision as of 09:19, 5 January 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7t8j is ON HOLD	+	The entry 7t8j is ON HOLD until Paper Publication

	Authors: Soleimani, S., Pedroza Romo, M.J., Smith, T., Brown, S., Doukov, T., Moody, J.D.		Authors: Soleimani, S., Pedroza Romo, M.J., Smith, T., Brown, S., Doukov, T., Moody, J.D.

OCA: Protected "7t8j" [edit=sysop:move=sysop]

OCA — Wed, 22 Dec 2021 14:10:47 GMT

Protected "7t8j" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:10, 22 December 2021

OCA: New page: '''Unreleased structure''' The entry 7t8j is ON HOLD Authors: Soleimani, S., Pedroza Romo, M.J., Smith, T., Brown, S., Doukov, T., Moody, J.D. Description: The ubiquitin-associated dom...

OCA — Wed, 22 Dec 2021 14:10:46 GMT

New page: '''Unreleased structure''' The entry 7t8j is ON HOLD Authors: Soleimani, S., Pedroza Romo, M.J., Smith, T., Brown, S., Doukov, T., Moody, J.D. Description: The ubiquitin-associated dom...

New page

'''Unreleased structure'''

The entry 7t8j is ON HOLD

Authors: Soleimani, S., Pedroza Romo, M.J., Smith, T., Brown, S., Doukov, T., Moody, J.D.

Description: The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL crystallization chaperone via a 4-glycine linker
[[Category: Unreleased Structures]]
[[Category: Pedroza Romo, M.J]]
[[Category: Moody, J.D]]
[[Category: Soleimani, S]]
[[Category: Doukov, T]]
[[Category: Smith, T]]
[[Category: Brown, S]]