7t8u - Revision history

OCA at 13:07, 1 March 2024

OCA — Fri, 01 Mar 2024 13:07:45 GMT

←Older revision		Revision as of 13:07, 1 March 2024
Line 3:		Line 3:
	<StructureSection load='7t8u' size='340' side='right'caption='[[7t8u]], [[Resolution\|resolution]] 4.30Å' scene=''>		<StructureSection load='7t8u' size='340' side='right'caption='[[7t8u]], [[Resolution\|resolution]] 4.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7t8u]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T8U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7t8u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T8U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t8u OCA], [https://pdbe.org/7t8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t8u RCSB], [https://www.ebi.ac.uk/pdbsum/7t8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t8u ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t8u OCA], [https://pdbe.org/7t8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t8u RCSB], [https://www.ebi.ac.uk/pdbsum/7t8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t8u ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/H9BRQ4_STAAU H9BRQ4_STAAU]
-	SignificanceThe formation of cross-alpha amyloids has been shown by crystallographic analysis of the highly cytolytic peptide PSMalpha3, a secreted virulence factor associated with the human pathogen Staphylococcus aureus. However, the relationship of the crystallographic cross-alpha structure to self-assembled filaments of PSMalpha3 and its relevance to other phenol-soluble modulin (PSM) peptides remained an open question. We report the cryo-electron microscopy structural analysis of three nanotubes derived from self-assembly of PSMalpha3 and PSMbeta2 peptides in aqueous solution. In each case, the nanotubes are derived from self-association of cross-alpha amyloid protofilaments. The self-assembly behavior of S. aureus PSMalpha3 and PSMbeta2 peptides provides strong evidence for the importance of the cross-alpha fold in self-assembled peptide and protein structures in general and for PSMs in particular.	+
-		+
-	Phenol-soluble modulins PSMalpha3 and PSMbeta2 form nanotubes that are cross-alpha amyloids.,Kreutzberger MAB, Wang S, Beltran LC, Tuachi A, Zuo X, Egelman EH, Conticello VP Proc Natl Acad Sci U S A. 2022 May 17;119(20):~~e2121586119. doi:, 10.1073~~/~~pnas.2121586119. Epub 2022 May 9. PMID:35533283<ref>PMID:35533283<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 7t8u" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Conicello, V P~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: ~~Egelman, E H~~]]	+	[[Category: Conicello VP]]
-	[[Category: ~~Kreutzberger, M A~~]]	+	[[Category: Egelman EH]]
-	[[Category: ~~Wang, S~~]]	+	[[Category: Kreutzberger MA]]
-	[[Category: ~~Amyloid]]~~	+	[[Category: Wang S]]
-	~~[[Category: Cross-alpha]]~~	+
-	~~[[Category: Nanotube]]~~	+
-	~~[[Category: Protein fibril~~]]	+

OCA at 08:16, 25 May 2022

OCA — Wed, 25 May 2022 08:16:47 GMT

←Older revision		Revision as of 08:16, 25 May 2022
Line 1:		Line 1:

	==Structure of PSMbeta2 nanotubes==		==Structure of PSMbeta2 nanotubes==
-	<StructureSection load='7t8u' size='340' side='right'caption='[[7t8u]]' scene=''>	+	<StructureSection load='7t8u' size='340' side='right'caption='[[7t8u]], [[Resolution\|resolution]] 4.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T8U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7t8u]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T8U FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t8u OCA], [https://pdbe.org/7t8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t8u RCSB], [https://www.ebi.ac.uk/pdbsum/7t8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t8u ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t8u OCA], [https://pdbe.org/7t8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t8u RCSB], [https://www.ebi.ac.uk/pdbsum/7t8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t8u ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SignificanceThe formation of cross-alpha amyloids has been shown by crystallographic analysis of the highly cytolytic peptide PSMalpha3, a secreted virulence factor associated with the human pathogen Staphylococcus aureus. However, the relationship of the crystallographic cross-alpha structure to self-assembled filaments of PSMalpha3 and its relevance to other phenol-soluble modulin (PSM) peptides remained an open question. We report the cryo-electron microscopy structural analysis of three nanotubes derived from self-assembly of PSMalpha3 and PSMbeta2 peptides in aqueous solution. In each case, the nanotubes are derived from self-association of cross-alpha amyloid protofilaments. The self-assembly behavior of S. aureus PSMalpha3 and PSMbeta2 peptides provides strong evidence for the importance of the cross-alpha fold in self-assembled peptide and protein structures in general and for PSMs in particular.
		+
		+	Phenol-soluble modulins PSMalpha3 and PSMbeta2 form nanotubes that are cross-alpha amyloids.,Kreutzberger MAB, Wang S, Beltran LC, Tuachi A, Zuo X, Egelman EH, Conticello VP Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2121586119. doi:, 10.1073/pnas.2121586119. Epub 2022 May 9. PMID:35533283<ref>PMID:35533283</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7t8u" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Conicello VP]]	+	[[Category: Conicello, V P]]
-	[[Category: Egelman EH]]	+	[[Category: Egelman, E H]]
-	[[Category: Kreutzberger MA]]	+	[[Category: Kreutzberger, M A]]
-	[[Category: Wang S]]	+	[[Category: Wang, S]]
		+	[[Category: Amyloid]]
		+	[[Category: Cross-alpha]]
		+	[[Category: Nanotube]]
		+	[[Category: Protein fibril]]

OCA at 10:16, 18 May 2022

OCA — Wed, 18 May 2022 10:16:58 GMT

←Older revision		Revision as of 10:16, 18 May 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7t8u is ~~ON HOLD until Paper Publication~~	+	==Structure of PSMbeta2 nanotubes==
-		+	<StructureSection load='7t8u' size='340' side='right'caption='[[7t8u]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T8U FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t8u OCA], [https://pdbe.org/7t8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t8u RCSB], [https://www.ebi.ac.uk/pdbsum/7t8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t8u ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Conicello VP]]
		+	[[Category: Egelman EH]]
		+	[[Category: Kreutzberger MA]]
		+	[[Category: Wang S]]

OCA at 09:20, 5 January 2022

OCA — Wed, 05 Jan 2022 09:20:01 GMT

←Older revision		Revision as of 09:20, 5 January 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7t8u is ON HOLD	+	The entry 7t8u is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7t8u" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2021 12:03:47 GMT

Protected "7t8u" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:03, 29 December 2021

OCA: New page: '''Unreleased structure''' The entry 7t8u is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Dec 2021 12:03:46 GMT

New page: '''Unreleased structure''' The entry 7t8u is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7t8u is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]