7t9b - Revision history

OCA at 05:51, 5 July 2023

OCA — Wed, 05 Jul 2023 05:51:11 GMT

←Older revision		Revision as of 05:51, 5 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7t9b]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1], [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T9B FirstGlance]. <br>		<table><tr><td colspan='2'>[[7t9b]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1], [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T9B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.72Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t9b OCA], [https://pdbe.org/7t9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t9b RCSB], [https://www.ebi.ac.uk/pdbsum/7t9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t9b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t9b OCA], [https://pdbe.org/7t9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t9b RCSB], [https://www.ebi.ac.uk/pdbsum/7t9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t9b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]	+	[https://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:14, 28 September 2022

OCA — Wed, 28 Sep 2022 06:14:57 GMT

←Older revision		Revision as of 06:14, 28 September 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7t9b is ~~ON HOLD~~	+	==ApexGT5 in complex with GT5-d42.16 and RM20A3 Fabs==
-		+	<StructureSection load='7t9b' size='340' side='right'caption='[[7t9b]], [[Resolution\|resolution]] 3.72Å' scene=''>
-	~~Authors~~: ~~Berndsen~~, Z.T.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7t9b]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1], [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T9B FirstGlance]. <br>
-	~~Description~~: ~~ApexGT5 in complex~~ with ~~GT5~~-~~d42~~.16 and ~~RM20A3 Fabs~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t9b OCA], [https://pdbe.org/7t9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t9b RCSB], [https://www.ebi.ac.uk/pdbsum/7t9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t9b ProSAT]</span></td></tr>
-	[[Category: Berndsen~~, Z.T~~]]	+	</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
		+	[[Category: Large Structures]]
		+	[[Category: Macaca mulatta]]
		+	[[Category: Mus musculus]]
		+	[[Category: Berndsen ZT]]

OCA: Protected "7t9b" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2021 12:04:54 GMT

Protected "7t9b" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:04, 29 December 2021

OCA: New page: '''Unreleased structure''' The entry 7t9b is ON HOLD Authors: Berndsen, Z.T. Description: ApexGT5 in complex with GT5-d42.16 and RM20A3 Fabs Category: Unreleased Structures [[Categ...

OCA — Wed, 29 Dec 2021 12:04:52 GMT

New page: '''Unreleased structure''' The entry 7t9b is ON HOLD Authors: Berndsen, Z.T. Description: ApexGT5 in complex with GT5-d42.16 and RM20A3 Fabs Category: Unreleased Structures [[Categ...

New page

'''Unreleased structure'''

The entry 7t9b is ON HOLD

Authors: Berndsen, Z.T.

Description: ApexGT5 in complex with GT5-d42.16 and RM20A3 Fabs
[[Category: Unreleased Structures]]
[[Category: Berndsen, Z.T]]