7t9i - Revision history

OCA at 03:17, 8 September 2022

OCA — Thu, 08 Sep 2022 03:17:30 GMT

←Older revision		Revision as of 03:17, 8 September 2022
Line 1:		Line 1:

	==Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)==		==Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)==
-	<StructureSection load='7t9i' size='340' side='right'caption='[[7t9i]]' scene=''>	+	<StructureSection load='7t9i' size='340' side='right'caption='[[7t9i]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T9I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7t9i]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T9I FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t9i OCA], [https://pdbe.org/7t9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t9i RCSB], [https://www.ebi.ac.uk/pdbsum/7t9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t9i ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t9i OCA], [https://pdbe.org/7t9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t9i RCSB], [https://www.ebi.ac.uk/pdbsum/7t9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t9i ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/GLHA_HUMAN GLHA_HUMAN]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thyroid hormones are vital to metabolism, growth and development(1). Thyroid hormone synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR)(2). Autoantibodies that activate the TSHR pathologically increase thyroid hormones in Graves' disease(3). How autoantibodies mimic TSH function remains unclear. We determined cryogenic-electron microscopy structures of active and inactive TSHR. In inactive TSHR, the extracellular domain lies close to the membrane bilayer. TSH selects an upright orientation of the extracellular domain due to steric clashes between a conserved hormone glycan and the membrane bilayer. An activating autoantibody from a Graves' disease patient selects a similar upright orientation of the extracellular domain. Reorientation of the extracellular domain transduces a conformational change in the seven transmembrane domain via a conserved hinge domain, a tethered peptide agonist, and a phospholipid that binds within the seven transmembrane domain. Rotation of the TSHR extracellular domain relative to the membrane bilayer is sufficient for receptor activation, revealing a shared mechanism for other glycoprotein hormone receptors that may also extend to other G protein-coupled receptors with large extracellular domains.
		+
		+	Autoantibody mimicry of hormone action at the thyrotropin receptor.,Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A Nature. 2022 Aug 8. pii: 10.1038/s41586-022-05159-1. doi:, 10.1038/s41586-022-05159-1. PMID:35940205<ref>PMID:35940205</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7t9i" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Lama glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cheng Y]]		[[Category: Cheng Y]]
	[[Category: Faust B]]		[[Category: Faust B]]
	[[Category: Manglik A]]		[[Category: Manglik A]]

OCA at 11:08, 31 August 2022

OCA — Wed, 31 Aug 2022 11:08:59 GMT

←Older revision		Revision as of 11:08, 31 August 2022
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-	====	+	==Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)==
	<StructureSection load='7t9i' size='340' side='right'caption='[[7t9i]]' scene=''>		<StructureSection load='7t9i' size='340' side='right'caption='[[7t9i]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T9I FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t9i OCA], [https://pdbe.org/7t9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t9i RCSB], [https://www.ebi.ac.uk/pdbsum/7t9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t9i ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t9i OCA], [https://pdbe.org/7t9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t9i RCSB], [https://www.ebi.ac.uk/pdbsum/7t9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t9i ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Cheng Y]]
		+	[[Category: Faust B]]
		+	[[Category: Manglik A]]

OCA at 04:53, 3 August 2022

OCA — Wed, 03 Aug 2022 04:53:24 GMT

←Older revision		Revision as of 04:53, 3 August 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7t9i ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7t9i' size='340' side='right'caption='[[7t9i]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t9i OCA], [https://pdbe.org/7t9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t9i RCSB], [https://www.ebi.ac.uk/pdbsum/7t9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t9i ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 16:18, 27 July 2022

OCA — Wed, 27 Jul 2022 16:18:51 GMT

←Older revision		Revision as of 16:18, 27 July 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7t9i is ON HOLD ~~until Paper Publication~~	+	The entry 7t9i is ON HOLD

	Authors:		Authors:

OCA at 08:36, 12 January 2022

OCA — Wed, 12 Jan 2022 08:36:27 GMT

←Older revision		Revision as of 08:36, 12 January 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7t9i is ON HOLD	+	The entry 7t9i is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7t9i" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2021 12:05:24 GMT

Protected "7t9i" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:05, 29 December 2021

OCA: New page: '''Unreleased structure''' The entry 7t9i is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Dec 2021 12:05:22 GMT

New page: '''Unreleased structure''' The entry 7t9i is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7t9i is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]