OCA at 08:17, 25 May 2022

OCA — Wed, 25 May 2022 08:17:09 GMT

←Older revision		Revision as of 08:17, 25 May 2022
Line 1:		Line 1:

	==Structure of P. aeruginosa PA17 CapW==		==Structure of P. aeruginosa PA17 CapW==
-	<StructureSection load='7tb5' size='340' side='right'caption='[[7tb5]]' scene=''>	+	<StructureSection load='7tb5' size='340' side='right'caption='[[7tb5]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TB5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7tb5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TB5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tb5 OCA], [https://pdbe.org/7tb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tb5 RCSB], [https://www.ebi.ac.uk/pdbsum/7tb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tb5 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tb5 OCA], [https://pdbe.org/7tb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tb5 RCSB], [https://www.ebi.ac.uk/pdbsum/7tb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tb5 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacteria use diverse immune systems to defend themselves from ubiquitous viruses termed bacteriophages (phages). Many anti-phage systems function by abortive infection to kill a phage-infected cell, raising the question of how they are regulated to avoid cell killing outside the context of infection. Here, we identify a transcription factor associated with the widespread CBASS bacterial immune system, that we term CapW. CapW forms a homodimer and binds a palindromic DNA sequence in the CBASS promoter region. Two crystal structures of CapW suggest that the protein switches from an unliganded, DNA binding-competent state to a ligand-bound state unable to bind DNA. We show that CapW strongly represses CBASS gene expression in uninfected cells, and that phage infection causes increased CBASS expression in a CapW-dependent manner. Unexpectedly, this CapW-dependent increase in CBASS expression is not required for robust anti-phage activity, suggesting that CapW may mediate CBASS activation and cell death in response to a signal other than phage infection. Our results parallel concurrent reports on the structure and activity of BrxR, a transcription factor associated with the BREX anti-phage system, suggesting that CapW and BrxR are members of a family of universal defense signaling proteins.
		+
		+	Control of bacterial immune signaling by a WYL domain transcription factor.,Blankenchip CL, Nguyen JV, Lau RK, Ye Q, Gu Y, Corbett KD Nucleic Acids Res. 2022 May 20;50(9):5239-5250. doi: 10.1093/nar/gkac343. PMID:35536256<ref>PMID:35536256</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7tb5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blankenchip CL]]	+	[[Category: Blankenchip, C L]]
-	[[Category: Corbett KD]]	+	[[Category: Corbett, K D]]
-	[[Category: Lau RK]]	+	[[Category: Lau, R K]]
-	[[Category: Nguyen JV]]	+	[[Category: Nguyen, J V]]
-	[[Category: Ye Q]]	+	[[Category: Ye, Q]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Helix-turn-helix]]
		+	[[Category: Transcription factor]]
		+	[[Category: Winged helix]]
		+	[[Category: Wyl]]

OCA at 07:32, 19 January 2022

OCA — Wed, 19 Jan 2022 07:32:13 GMT

←Older revision		Revision as of 07:32, 19 January 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7tb5 is ~~ON HOLD~~	+	==Structure of P. aeruginosa PA17 CapW==
-		+	<StructureSection load='7tb5' size='340' side='right'caption='[[7tb5]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TB5 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tb5 OCA], [https://pdbe.org/7tb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tb5 RCSB], [https://www.ebi.ac.uk/pdbsum/7tb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tb5 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Blankenchip CL]]
		+	[[Category: Corbett KD]]
		+	[[Category: Lau RK]]
		+	[[Category: Nguyen JV]]
		+	[[Category: Ye Q]]

OCA: Protected "7tb5" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2021 12:09:10 GMT

Protected "7tb5" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:09, 29 December 2021

OCA: New page: '''Unreleased structure''' The entry 7tb5 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Dec 2021 12:09:09 GMT

New page: '''Unreleased structure''' The entry 7tb5 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7tb5 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7tb5 - Revision history

OCA at 08:17, 25 May 2022

OCA at 07:32, 19 January 2022

OCA: Protected "7tb5" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7tb5 is ON HOLD Authors: Description: Category: Unreleased Structures