OCA at 04:12, 25 May 2023

OCA — Thu, 25 May 2023 04:12:28 GMT

←Older revision		Revision as of 04:12, 25 May 2023
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	==The structure of ATP-bound ABCA1==		==The structure of ATP-bound ABCA1==
-	<StructureSection load='7tbw' size='340' side='right'caption='[[7tbw]]' scene=''>	+	<StructureSection load='7tbw' size='340' side='right'caption='[[7tbw]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TBW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7tbw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TBW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tbw OCA], [https://pdbe.org/7tbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tbw RCSB], [https://www.ebi.ac.uk/pdbsum/7tbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tbw ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tbw OCA], [https://pdbe.org/7tbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tbw RCSB], [https://www.ebi.ac.uk/pdbsum/7tbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tbw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/ABCA1_HUMAN ABCA1_HUMAN] Tangier disease;Apolipoprotein A-I deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ABCA1_HUMAN ABCA1_HUMAN] cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ATP-binding cassette transporter A1 (ABCA1) utilizes energy derived from ATP hydrolysis to export cholesterol and phospholipids from macrophages. ABCA1 plays a central role in the biosynthesis of high-density lipoprotein (HDL), which mediates reverse cholesterol transport and prevents detrimental lipid deposition. Mutations in ABCA1 cause Tangier disease characterized by a remarkable reduction in the amount of HDL in blood. Here we present cryo-electron microscopy structures of human ABCA1 in ATP-bound and nucleotide-free states. Structural comparison reveals that ATP molecules pull the nucleotide-binding domains together, inducing movements of transmembrane helices 1, 2, 7 and 8 through a series of salt-bridge interactions. Subsequently, extracellular domains (ECDs) undergo a rotation and introduce conformational changes in the ECD-transmembrane interface. In addition, while we observe a sterol-like molecule in ECDs, no such density was observed in the structure of an HDL-deficiency mutant ABCA1(Y482C), demonstrating the physiological importance of ECDs and a putative interaction mode between ABCA1 and its lipid acceptors. Thus, these structures, along with cholesterol efflux assays, advance the understanding ABCA1-mediated reverse cholesterol transport.
		+
		+	Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states.,Sun Y, Li X Nat Cardiovasc Res. 2022;1(3):238-245. doi: 10.1038/s44161-022-00022-y. Epub 2022 , Mar 3. PMID:37181814<ref>PMID:37181814</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7tbw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ABC transporter 3D structures\|ABC transporter 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Li X]]		[[Category: Li X]]
	[[Category: Sun Y]]		[[Category: Sun Y]]

OCA at 07:04, 27 January 2022

OCA — Thu, 27 Jan 2022 07:04:15 GMT

←Older revision		Revision as of 07:04, 27 January 2022
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-	'''Unreleased structure'''

-	The ~~entry~~ 7tbw ~~is ON HOLD~~	+	==The structure of ATP-bound ABCA1==
-		+	<StructureSection load='7tbw' size='340' side='right'caption='[[7tbw]]' scene=''>
-	~~Authors~~: ~~Sun~~, Y., Li, X.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TBW FirstGlance]. <br>
-	~~Description~~: ~~The structure of ATP~~-~~bound ABCA1~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tbw OCA], [https://pdbe.org/7tbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tbw RCSB], [https://www.ebi.ac.uk/pdbsum/7tbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tbw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Li, X]]	+	__TOC__
-	[[Category: Sun, Y]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Li X]]
		+	[[Category: Sun Y]]

OCA: Protected "7tbw" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2021 12:11:28 GMT

Protected "7tbw" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:11, 29 December 2021

OCA: New page: '''Unreleased structure''' The entry 7tbw is ON HOLD Authors: Sun, Y., Li, X. Description: The structure of ATP-bound ABCA1 Category: Unreleased Structures Category: Li, X [[Ca...

OCA — Wed, 29 Dec 2021 12:11:27 GMT

New page: '''Unreleased structure''' The entry 7tbw is ON HOLD Authors: Sun, Y., Li, X. Description: The structure of ATP-bound ABCA1 Category: Unreleased Structures Category: Li, X [[Ca...

New page

'''Unreleased structure'''

The entry 7tbw is ON HOLD

Authors: Sun, Y., Li, X.

Description: The structure of ATP-bound ABCA1
[[Category: Unreleased Structures]]
[[Category: Li, X]]
[[Category: Sun, Y]]

7tbw - Revision history

OCA at 04:12, 25 May 2023

OCA at 07:04, 27 January 2022

OCA: Protected "7tbw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7tbw is ON HOLD Authors: Sun, Y., Li, X. Description: The structure of ATP-bound ABCA1 Category: Unreleased Structures Category: Li, X [[Ca...