7tdr - Revision history

OCA at 18:57, 7 September 2022

OCA — Wed, 07 Sep 2022 18:57:35 GMT

←Older revision		Revision as of 18:57, 7 September 2022
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	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/Q5MIU2_AEDAL Q5MIU2_AEDAL]]		[[https://www.uniprot.org/uniprot/Q5MIU2_AEDAL Q5MIU2_AEDAL]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mosquito proboscis is an efficient microelectromechanical system, which allows the insect to feed on vertebrate blood quickly and painlessly. Its efficiency is further enhanced by the insect saliva, although through unclear mechanisms. Here, we describe the initial trigger of an unprecedented feedback signaling pathway in Aedes mosquitoes affecting feeding behavior. We identified LIPS proteins in the saliva of Aedes mosquitoes that promote feeding in the vertebrate skin. LIPS show a new all-helical protein fold constituted by two domains. The N-terminal domain interacts with a cuticular protein (Cp19) located at the tip of the mosquito labrum. Upon interaction, the morphology of the labral cuticle changes, and this modification is most likely sensed by proprioceptive neurons. Our study identifies an additional role of mosquito saliva and underlines that the external cuticle is a possible site of key molecular interactions affecting the insect biology and its vector competence.
		+
		+	A salivary factor binds a cuticular protein and modulates biting by inducing morphological changes in the mosquito labrum.,Arnoldi I, Mancini G, Fumagalli M, Gastaldi D, D'Andrea L, Bandi C, Di Venere M, Iadarola P, Forneris F, Gabrieli P Curr Biol. 2022 Jul 7. pii: S0960-9822(22)01011-9. doi:, 10.1016/j.cub.2022.06.049. PMID:35835123<ref>PMID:35835123</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7tdr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:48, 7 September 2022

OCA — Wed, 07 Sep 2022 16:48:54 GMT

←Older revision		Revision as of 16:48, 7 September 2022
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	==Labrum-interacting protein from saliva LIPS-2 (34K-2) from Aedes albopictus, selenomethionine derivative==		==Labrum-interacting protein from saliva LIPS-2 (34K-2) from Aedes albopictus, selenomethionine derivative==
-	<StructureSection load='7tdr' size='340' side='right'caption='[[7tdr]]' scene=''>	+	<StructureSection load='7tdr' size='340' side='right'caption='[[7tdr]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TDR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7tdr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_albopictus Aedes albopictus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TDR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tdr OCA], [https://pdbe.org/7tdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tdr RCSB], [https://www.ebi.ac.uk/pdbsum/7tdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tdr ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tdr OCA], [https://pdbe.org/7tdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tdr RCSB], [https://www.ebi.ac.uk/pdbsum/7tdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tdr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q5MIU2_AEDAL Q5MIU2_AEDAL]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aedes albopictus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Forneris F]]		[[Category: Forneris F]]
	[[Category: Gabrieli P]]		[[Category: Gabrieli P]]

OCA at 18:05, 27 July 2022

OCA — Wed, 27 Jul 2022 18:05:04 GMT

←Older revision		Revision as of 18:05, 27 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7tdr ~~is ON HOLD until Paper Publication~~	+	==Labrum-interacting protein from saliva LIPS-2 (34K-2) from Aedes albopictus, selenomethionine derivative==
-		+	<StructureSection load='7tdr' size='340' side='right'caption='[[7tdr]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TDR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tdr OCA], [https://pdbe.org/7tdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tdr RCSB], [https://www.ebi.ac.uk/pdbsum/7tdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tdr ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Forneris F]]
		+	[[Category: Gabrieli P]]

OCA at 06:16, 9 February 2022

OCA — Wed, 09 Feb 2022 06:16:36 GMT

←Older revision		Revision as of 06:16, 9 February 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7tdr is ON HOLD	+	The entry 7tdr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7tdr" [edit=sysop:move=sysop]

OCA — Wed, 12 Jan 2022 08:37:33 GMT

Protected "7tdr" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:37, 12 January 2022

OCA: New page: '''Unreleased structure''' The entry 7tdr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Jan 2022 08:37:32 GMT

New page: '''Unreleased structure''' The entry 7tdr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7tdr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]