OCA at 07:03, 29 March 2023

OCA — Wed, 29 Mar 2023 07:03:00 GMT

←Older revision		Revision as of 07:03, 29 March 2023
Line 1:		Line 1:

-	====	+	==Structure of the SARS-CoV-2 Omicron spike post-fusion bundle==
-	<StructureSection load='7tik' size='340' side='right'caption='[[7tik]]' scene=''>	+	<StructureSection load='7tik' size='340' side='right'caption='[[7tik]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7tik]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_punctiforme_PCC_73102 Nostoc punctiforme PCC 73102] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TIK FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tik OCA], [https://pdbe.org/7tik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tik RCSB], [https://www.ebi.ac.uk/pdbsum/7tik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tik ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tik OCA], [https://pdbe.org/7tik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tik RCSB], [https://www.ebi.ac.uk/pdbsum/7tik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tik ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099][https://www.uniprot.org/uniprot/B2J981_NOSP7 B2J981_NOSP7]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Nostoc punctiforme PCC 73102]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Brunger AT]]
		+	[[Category: Yang K]]

OCA at 10:26, 6 April 2022

OCA — Wed, 06 Apr 2022 10:26:30 GMT

←Older revision		Revision as of 10:26, 6 April 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7tik ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7tik' size='340' side='right'caption='[[7tik]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tik OCA], [https://pdbe.org/7tik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tik RCSB], [https://www.ebi.ac.uk/pdbsum/7tik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tik ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7tik" [edit=sysop:move=sysop]

OCA — Wed, 19 Jan 2022 06:06:24 GMT

Protected "7tik" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:06, 19 January 2022

OCA: New page: '''Unreleased structure''' The entry 7tik is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Jan 2022 06:06:23 GMT

New page: '''Unreleased structure''' The entry 7tik is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7tik is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7tik - Revision history

OCA at 07:03, 29 March 2023

OCA at 10:26, 6 April 2022

OCA: Protected "7tik" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7tik is ON HOLD Authors: Description: Category: Unreleased Structures