OCA at 11:55, 27 April 2022

OCA — Wed, 27 Apr 2022 11:55:22 GMT

←Older revision		Revision as of 11:55, 27 April 2022
Line 1:		Line 1:

	==Porous framework formed by assembly of a bipyridyl-conjugated helical peptide==		==Porous framework formed by assembly of a bipyridyl-conjugated helical peptide==
-	<StructureSection load='7tls' size='340' side='right'caption='[[7tls]]' scene=''>	+	<StructureSection load='7tls' size='340' side='right'caption='[[7tls]], [[Resolution\|resolution]] 0.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TLS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7tls]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TLS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tls OCA], [https://pdbe.org/7tls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tls RCSB], [https://www.ebi.ac.uk/pdbsum/7tls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tls ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=I6W:ethyl+5-formyl[2,2-bipyridine]-5-carboxylate'>I6W</scene>, <scene name='pdbligand=I77:5-(hydrazinecarbonyl)[2,2-bipyridine]-5-carboxamide'>I77</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tls OCA], [https://pdbe.org/7tls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tls RCSB], [https://www.ebi.ac.uk/pdbsum/7tls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tls ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The evolution of proteins from simpler, self-assembled peptides provides a powerful blueprint for the design of complex synthetic materials. Previously, peptide-metal frameworks using short sequences (</=3 residues) have shown great promise as proteomimetic materials that exhibit sophisticated capabilities. However, their development has been hindered due to few variable residues and restricted choice of side-chains that are compatible with metal ions. Herein, we developed a noncovalent strategy featuring pi-stacking bipyridyl residues to assemble much longer peptides into crystalline frameworks that tolerate even previously incompatible acidic and basic functionalities and allow an unprecedented level of pore variations. Single-crystal X-ray structures are provided for all variants to guide and validate rational design. These materials exhibit hallmark proteomimetic behaviors such as guest-selective induced fit and assembly of multimetallic units. Significantly, we demonstrate facile optimization of the framework design to substantially increase affinity toward a complex organic molecule.
		+
		+	Assembly of pi-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework.,Heinz-Kunert SL, Pandya A, Dang VT, Tran PN, Ghosh S, McElheny D, Santarsiero BD, Ren Z, Nguyen AI J Am Chem Soc. 2022 Apr 20;144(15):7001-7009. doi: 10.1021/jacs.2c02146. Epub, 2022 Apr 7. PMID:35390261<ref>PMID:35390261</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7tls" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Nguyen AI]]	+	[[Category: Nguyen, A I]]
		+	[[Category: Alpha]]
		+	[[Category: Assembly]]
		+	[[Category: Bipyridine]]
		+	[[Category: De novo protein]]
		+	[[Category: Framework]]
		+	[[Category: Helix]]
		+	[[Category: Porous]]
		+	[[Category: Uic-1]]

OCA at 02:57, 21 April 2022

OCA — Thu, 21 Apr 2022 02:57:15 GMT

←Older revision		Revision as of 02:57, 21 April 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7tls ~~is ON HOLD until Paper Publication~~	+	==Porous framework formed by assembly of a bipyridyl-conjugated helical peptide==
-		+	<StructureSection load='7tls' size='340' side='right'caption='[[7tls]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TLS FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tls OCA], [https://pdbe.org/7tls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tls RCSB], [https://www.ebi.ac.uk/pdbsum/7tls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tls ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Nguyen AI]]

OCA at 05:36, 2 February 2022

OCA — Wed, 02 Feb 2022 05:36:27 GMT

←Older revision		Revision as of 05:36, 2 February 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7tls is ON HOLD	+	The entry 7tls is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7tls" [edit=sysop:move=sysop]

OCA — Thu, 27 Jan 2022 05:35:20 GMT

Protected "7tls" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:35, 27 January 2022

OCA: New page: '''Unreleased structure''' The entry 7tls is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 27 Jan 2022 05:35:19 GMT

New page: '''Unreleased structure''' The entry 7tls is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7tls is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7tls - Revision history

OCA at 11:55, 27 April 2022

OCA at 02:57, 21 April 2022

OCA at 05:36, 2 February 2022

OCA: Protected "7tls" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7tls is ON HOLD Authors: Description: Category: Unreleased Structures