7tpb - Revision history

OCA at 17:06, 18 October 2023

OCA — Wed, 18 Oct 2023 17:06:37 GMT

←Older revision		Revision as of 17:06, 18 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7tpb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TPB FirstGlance]. <br>		<table><tr><td colspan='2'>[[7tpb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TPB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tpb OCA], [https://pdbe.org/7tpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tpb RCSB], [https://www.ebi.ac.uk/pdbsum/7tpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tpb ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tpb OCA], [https://pdbe.org/7tpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tpb RCSB], [https://www.ebi.ac.uk/pdbsum/7tpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tpb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/B4DTL8_HUMAN B4DTL8_HUMAN]]	+	[https://www.uniprot.org/uniprot/B4DTL8_HUMAN B4DTL8_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7tpb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7tpb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rho GTPase activating protein 3D structures\|Rho GTPase activating protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:17, 8 September 2022

OCA — Thu, 08 Sep 2022 03:17:58 GMT

←Older revision		Revision as of 03:17, 8 September 2022
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	==p120RasGAP SH3 domain in complex with DLC1 RhoGAP domain==		==p120RasGAP SH3 domain in complex with DLC1 RhoGAP domain==
-	<StructureSection load='7tpb' size='340' side='right'caption='[[7tpb]]' scene=''>	+	<StructureSection load='7tpb' size='340' side='right'caption='[[7tpb]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TPB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7tpb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TPB FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tpb OCA], [https://pdbe.org/7tpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tpb RCSB], [https://www.ebi.ac.uk/pdbsum/7tpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tpb ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tpb OCA], [https://pdbe.org/7tpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tpb RCSB], [https://www.ebi.ac.uk/pdbsum/7tpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tpb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/B4DTL8_HUMAN B4DTL8_HUMAN]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RhoGAP proteins are key regulators of Rho family GTPases and influence a variety of cellular processes, including cell migration, adhesion, and cytokinesis. These GTPase activating proteins (GAPs) downregulate Rho signaling by binding and enhancing the intrinsic GTPase activity of Rho proteins. Deleted in liver cancer 1 (DLC1) is a tumor suppressor and ubiquitously expressed RhoGAP protein; its activity is regulated in part by binding p120RasGAP, a GAP protein for the Ras GTPases. In this study, we report the co-crystal structure of the p120RasGAP SH3 domain bound directly to DLC1 RhoGAP, at a site partially overlapping the RhoA binding site and impinging on the catalytic arginine finger. We demonstrate biochemically that mutation of this interface relieves inhibition of RhoGAP activity by the SH3 domain. These results reveal the mechanism for inhibition of DLC1 RhoGAP activity by p120RasGAP and demonstrate the molecular basis for direct SH3 domain modulation of GAP activity.
		+
		+	SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP.,Chau JE, Vish KJ, Boggon TJ, Stiegler AL Nat Commun. 2022 Aug 15;13(1):4788. doi: 10.1038/s41467-022-32541-4. PMID:35970859<ref>PMID:35970859</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7tpb" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Boggon TJ]]		[[Category: Boggon TJ]]

OCA at 11:09, 31 August 2022

OCA — Wed, 31 Aug 2022 11:09:40 GMT

←Older revision		Revision as of 11:09, 31 August 2022
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-	====	+	==p120RasGAP SH3 domain in complex with DLC1 RhoGAP domain==
	<StructureSection load='7tpb' size='340' side='right'caption='[[7tpb]]' scene=''>		<StructureSection load='7tpb' size='340' side='right'caption='[[7tpb]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TPB FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tpb OCA], [https://pdbe.org/7tpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tpb RCSB], [https://www.ebi.ac.uk/pdbsum/7tpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tpb ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tpb OCA], [https://pdbe.org/7tpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tpb RCSB], [https://www.ebi.ac.uk/pdbsum/7tpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tpb ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Boggon TJ]]
		+	[[Category: Chau JE]]
		+	[[Category: Stiegler AL]]
		+	[[Category: Vish KJ]]

OCA at 04:53, 3 August 2022

OCA — Wed, 03 Aug 2022 04:53:32 GMT

←Older revision		Revision as of 04:53, 3 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7tpb ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7tpb' size='340' side='right'caption='[[7tpb]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tpb OCA], [https://pdbe.org/7tpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tpb RCSB], [https://www.ebi.ac.uk/pdbsum/7tpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tpb ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 06:31, 23 February 2022

OCA — Wed, 23 Feb 2022 06:31:08 GMT

←Older revision		Revision as of 06:31, 23 February 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7tpb is ON HOLD	+	The entry 7tpb is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7tpb" [edit=sysop:move=sysop]

OCA — Wed, 02 Feb 2022 05:40:25 GMT

Protected "7tpb" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:40, 2 February 2022

OCA: New page: '''Unreleased structure''' The entry 7tpb is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Feb 2022 05:40:24 GMT

New page: '''Unreleased structure''' The entry 7tpb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7tpb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]