7tqg - Revision history

OCA at 09:47, 25 October 2023

OCA — Wed, 25 Oct 2023 09:47:45 GMT

←Older revision		Revision as of 09:47, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7tqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TQG FirstGlance]. <br>		<table><tr><td colspan='2'>[[7tqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TQG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tqg OCA], [https://pdbe.org/7tqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tqg RCSB], [https://www.ebi.ac.uk/pdbsum/7tqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tqg ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.07Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tqg OCA], [https://pdbe.org/7tqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tqg RCSB], [https://www.ebi.ac.uk/pdbsum/7tqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tqg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:58, 2 March 2023

OCA — Thu, 02 Mar 2023 05:58:02 GMT

←Older revision		Revision as of 05:58, 2 March 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7tqg is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of IOMA Fab inferred germline==
		+	<StructureSection load='7tqg' size='340' side='right'caption='[[7tqg]], [[Resolution\|resolution]] 2.07Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7tqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TQG FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tqg OCA], [https://pdbe.org/7tqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tqg RCSB], [https://www.ebi.ac.uk/pdbsum/7tqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tqg ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Passive transfer of broadly neutralizing anti-HIV-1 antibodies (bNAbs) protects against infection, and therefore, eliciting bNAbs by vaccination is a major goal of HIV-1 vaccine efforts. bNAbs that target the CD4 binding site (CD4bs) on HIV-1 Env are among the most broadly active, but to date, responses elicited against this epitope in vaccinated animals have lacked potency and breadth. We hypothesized that CD4bs bNAbs resembling the antibody IOMA might be easier to elicit than other CD4bs antibodies that exhibit higher somatic mutation rates, a difficult-to-achieve mechanism to accommodate Env's N276(gp120) N-glycan, and rare five-residue light chain complementarity-determining region 3. As an initial test of this idea, we developed IOMA germline-targeting Env immunogens and evaluated a sequential immunization regimen in transgenic mice expressing germline-reverted IOMA. These mice developed CD4bs epitope-specific responses with heterologous neutralization, and cloned antibodies overcame neutralization roadblocks, including accommodating the N276(gp120) glycan, with some neutralizing selected HIV-1 strains more potently than IOMA. The immunization regimen also elicited CD4bs-specific responses in mice containing polyclonal antibody repertoires as well as rabbits and rhesus macaques. Thus, germline targeting of IOMA-class antibody precursors represents a potential vaccine strategy to induce CD4bs bNAbs.

-	~~Authors~~:	+	CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals.,Gristick HB, Hartweger H, Loewe M, van Schooten J, Ramos V, Oliveira TY, Nishimura Y, Koranda NS, Wall A, Yao KH, Poston D, Gazumyan A, Wiatr M, Horning M, Keeffe JR, Hoffmann MAG, Yang Z, Abernathy ME, Dam KA, Gao H, Gnanapragasam PNP, Kakutani LM, Pavlovitch-Bedzyk AJ, Seaman MS, Howarth M, McGuire AT, Stamatatos L, Martin MA, West AP Jr, Nussenzweig MC, Bjorkman PJ Sci Immunol. 2023 Feb 17;8(80):eade6364. doi: 10.1126/sciimmunol.ade6364. Epub , 2023 Feb 10. PMID:36763635<ref>PMID:36763635</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7tqg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Bjorkman PJ]]
		+	[[Category: Gristick HB]]

OCA at 04:59, 16 March 2022

OCA — Wed, 16 Mar 2022 04:59:50 GMT

←Older revision		Revision as of 04:59, 16 March 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7tqg is ON HOLD	+	The entry 7tqg is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7tqg" [edit=sysop:move=sysop]

OCA — Wed, 02 Feb 2022 05:42:46 GMT

Protected "7tqg" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 2 February 2022

OCA: New page: '''Unreleased structure''' The entry 7tqg is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Feb 2022 05:42:45 GMT

New page: '''Unreleased structure''' The entry 7tqg is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7tqg is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]