7tzk - Revision history

OCA at 17:09, 18 October 2023

OCA — Wed, 18 Oct 2023 17:09:29 GMT

←Older revision		Revision as of 17:09, 18 October 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7tzk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O127:H6_str._E2348/69 Escherichia coli O127:H6 str. E2348/69] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZK FirstGlance]. <br>		<table><tr><td colspan='2'>[[7tzk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O127:H6_str._E2348/69 Escherichia coli O127:H6 str. E2348/69] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tzk OCA], [https://pdbe.org/7tzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tzk RCSB], [https://www.ebi.ac.uk/pdbsum/7tzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tzk ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.43Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tzk OCA], [https://pdbe.org/7tzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tzk RCSB], [https://www.ebi.ac.uk/pdbsum/7tzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tzk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/EPS8_HUMAN EPS8_HUMAN]] Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.	+	[https://www.uniprot.org/uniprot/EPS8_HUMAN EPS8_HUMAN] Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 19:49, 7 September 2022

OCA — Wed, 07 Sep 2022 19:49:42 GMT

←Older revision		Revision as of 19:49, 7 September 2022
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-	====	+	==EPS8 SH3 Domain with NleH1 PxxDY Motif==
-	<StructureSection load='7tzk' size='340' side='right'caption='[[7tzk]]' scene=''>	+	<StructureSection load='7tzk' size='340' side='right'caption='[[7tzk]], [[Resolution\|resolution]] 1.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7tzk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O127:H6_str._E2348/69 Escherichia coli O127:H6 str. E2348/69] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZK FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tzk OCA], [https://pdbe.org/7tzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tzk RCSB], [https://www.ebi.ac.uk/pdbsum/7tzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tzk ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tzk OCA], [https://pdbe.org/7tzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tzk RCSB], [https://www.ebi.ac.uk/pdbsum/7tzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tzk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/EPS8_HUMAN EPS8_HUMAN]] Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Attaching and effacing (AE) lesion formation on enterocytes by enteropathogenic Escherichia coli (EPEC) requires the EPEC type III secretion system (T3SS). Two T3SS effectors injected into the host cell during infection are the atypical kinases, NleH1 and NleH2. However, the host targets of NleH1 and NleH2 kinase activity during infection have not been reported. Here phosphoproteomics identified Ser775 in the microvillus protein Eps8 as a bona fide target of NleH1 and NleH2 phosphorylation. Both kinases interacted with Eps8 through previously unrecognized, noncanonical "proline-rich" motifs, PxxDY, that bound the Src Homology 3 (SH3) domain of Eps8. Structural analysis of the Eps8 SH3 domain bound to a peptide containing one of the proline-rich motifs from NleH showed that the N-terminal part of the peptide adopts a type II polyproline helix, and its C-terminal "DY" segment makes multiple contacts with the SH3 domain. Ser775 phosphorylation by NleH1 or NleH2 hindered Eps8 bundling activity and drove dispersal of Eps8 from the AE lesion during EPEC infection. This finding suggested that NleH1 and NleH2 altered the cellular localization of Eps8 and the cytoskeletal composition of AE lesions during EPEC infection.
		+
		+	Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli.,Pollock GL, Grishin AM, Giogha C, Gan J, Oates CV, McMillan PJ, Gaeta I, Tyska MJ, Pearson JS, Scott NE, Cygler M, Hartland EL Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2204332119. doi:, 10.1073/pnas.2204332119. Epub 2022 Aug 17. PMID:35976880<ref>PMID:35976880</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7tzk" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli O127:H6 str. E2348/69]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Cygler M]]
		+	[[Category: Grishin AM]]

OCA at 16:14, 6 July 2022

OCA — Wed, 06 Jul 2022 16:14:31 GMT

←Older revision		Revision as of 16:14, 6 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7tzk ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7tzk' size='340' side='right'caption='[[7tzk]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tzk OCA], [https://pdbe.org/7tzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tzk RCSB], [https://www.ebi.ac.uk/pdbsum/7tzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tzk ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 09:47, 23 March 2022

OCA — Wed, 23 Mar 2022 09:47:23 GMT

←Older revision		Revision as of 09:47, 23 March 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7tzk is ON HOLD	+	The entry 7tzk is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7tzk" [edit=sysop:move=sysop]

OCA — Wed, 23 Feb 2022 06:34:49 GMT

Protected "7tzk" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:34, 23 February 2022

OCA: New page: '''Unreleased structure''' The entry 7tzk is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 23 Feb 2022 06:34:48 GMT

New page: '''Unreleased structure''' The entry 7tzk is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7tzk is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]