7u0k - Revision history

OCA at 17:09, 18 October 2023

OCA — Wed, 18 Oct 2023 17:09:53 GMT

←Older revision		Revision as of 17:09, 18 October 2023
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	==IOMA class antibody Fab ACS124==		==IOMA class antibody Fab ACS124==
-	<StructureSection load='7u0k' size='340' side='right'caption='[[7u0k]]' scene=''>	+	<StructureSection load='7u0k' size='340' side='right'caption='[[7u0k]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U0K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7u0k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U0K FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u0k OCA], [https://pdbe.org/7u0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u0k RCSB], [https://www.ebi.ac.uk/pdbsum/7u0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u0k ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.73Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u0k OCA], [https://pdbe.org/7u0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u0k RCSB], [https://www.ebi.ac.uk/pdbsum/7u0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u0k ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A major goal of current HIV-1 vaccine design efforts is to induce broadly neutralizing antibodies (bNAbs). The VH1-2-derived bNAb IOMA directed to the CD4-binding site of the HIV-1 envelope glycoprotein is of interest because, unlike the better-known VH1-2-derived VRC01-class bNAbs, it does not require a rare short light chain complementarity-determining region 3 (CDRL3). Here, we describe three IOMA-class NAbs, ACS101-103, with up to 37% breadth, that share many characteristics with IOMA, including an average-length CDRL3. Cryo-electron microscopy revealed that ACS101 shares interactions with those observed with other VH1-2 and VH1-46-class bNAbs, but exhibits a unique binding mode to residues in loop D. Analysis of longitudinal sequences from the patient suggests that a transmitter/founder-virus lacking the N276 glycan might have initiated the development of these NAbs. Together these data strengthen the rationale for germline-targeting vaccination strategies to induce IOMA-class bNAbs and provide a wealth of sequence and structural information to support such strategies.
		+
		+	Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein.,van Schooten J, Farokhi E, Schorcht A, van den Kerkhof TLGM, Gao H, van der Woude P, Burger JA, Meesters TGR, Bijl T, Ghalaiyini R, Turner HL, Dorning J, van Schaik BDC, van Kampen AHC, Labranche CC, Stanfield RL, Sok D, Montefiori DC, Burton DR, Seaman MS, Ozorowski G, Wilson IA, Sanders RW, Ward AB, van Gils MJ Nat Commun. 2022 Aug 3;13(1):4515. doi: 10.1038/s41467-022-32208-0. PMID:35922441<ref>PMID:35922441</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7u0k" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Farokhi E]]		[[Category: Farokhi E]]
	[[Category: Stanfield RL]]		[[Category: Stanfield RL]]
	[[Category: Wilson IA]]		[[Category: Wilson IA]]

OCA at 10:09, 31 August 2022

OCA — Wed, 31 Aug 2022 10:09:21 GMT

←Older revision		Revision as of 10:09, 31 August 2022
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-	====	+	==IOMA class antibody Fab ACS124==
	<StructureSection load='7u0k' size='340' side='right'caption='[[7u0k]]' scene=''>		<StructureSection load='7u0k' size='340' side='right'caption='[[7u0k]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U0K FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u0k OCA], [https://pdbe.org/7u0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u0k RCSB], [https://www.ebi.ac.uk/pdbsum/7u0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u0k ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u0k OCA], [https://pdbe.org/7u0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u0k RCSB], [https://www.ebi.ac.uk/pdbsum/7u0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u0k ProSAT]</span></td></tr>
	</table>		</table>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Farokhi E]]
		+	[[Category: Stanfield RL]]
		+	[[Category: Wilson IA]]

OCA at 04:49, 25 August 2022

OCA — Thu, 25 Aug 2022 04:49:45 GMT

←Older revision		Revision as of 04:49, 25 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7u0k ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7u0k' size='340' side='right'caption='[[7u0k]]' scene=''>
-	~~Authors~~: ~~Farokhi, E~~.~~, Stanfield, R~~.L.~~, Wilson, I~~.A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~IOMA~~ class ~~antibody Fab ACS124~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u0k OCA], [https://pdbe.org/7u0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u0k RCSB], [https://www.ebi.ac.uk/pdbsum/7u0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u0k ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Stanfield~~, R.L]]	+	__TOC__
-	[[Category: ~~Wilson, I.A~~]]	+	</StructureSection>
-	[[Category: ~~Farokhi, E~~]]	+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 10:21, 27 April 2022

OCA — Wed, 27 Apr 2022 10:21:54 GMT

←Older revision		Revision as of 10:21, 27 April 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7u0k is ON HOLD	+	The entry 7u0k is ON HOLD until Paper Publication

	Authors: Farokhi, E., Stanfield, R.L., Wilson, I.A.		Authors: Farokhi, E., Stanfield, R.L., Wilson, I.A.

OCA: Protected "7u0k" [edit=sysop:move=sysop]

OCA — Wed, 02 Mar 2022 05:06:17 GMT

Protected "7u0k" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:06, 2 March 2022

OCA: New page: '''Unreleased structure''' The entry 7u0k is ON HOLD Authors: Farokhi, E., Stanfield, R.L., Wilson, I.A. Description: IOMA class antibody Fab ACS124 Category: Unreleased Structures...

OCA — Wed, 02 Mar 2022 05:06:16 GMT

New page: '''Unreleased structure''' The entry 7u0k is ON HOLD Authors: Farokhi, E., Stanfield, R.L., Wilson, I.A. Description: IOMA class antibody Fab ACS124 Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 7u0k is ON HOLD

Authors: Farokhi, E., Stanfield, R.L., Wilson, I.A.

Description: IOMA class antibody Fab ACS124
[[Category: Unreleased Structures]]
[[Category: Stanfield, R.L]]
[[Category: Wilson, I.A]]
[[Category: Farokhi, E]]