7ug2 - Revision history

OCA at 09:52, 25 October 2023

OCA — Wed, 25 Oct 2023 09:52:42 GMT

←Older revision		Revision as of 09:52, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7ug2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UG2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ug2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UG2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.052Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ug2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ug2 OCA], [https://pdbe.org/7ug2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ug2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ug2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ug2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ug2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ug2 OCA], [https://pdbe.org/7ug2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ug2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ug2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ug2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:21, 15 February 2023

OCA — Wed, 15 Feb 2023 10:21:51 GMT

←Older revision		Revision as of 10:21, 15 February 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7ug2 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the coiled-coil domain of TRIM75==
		+	<StructureSection load='7ug2' size='340' side='right'caption='[[7ug2]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7ug2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UG2 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ug2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ug2 OCA], [https://pdbe.org/7ug2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ug2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ug2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ug2 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRI75_MOUSE TRI75_MOUSE] May play a role in female meiosis.<ref>PMID:26974323</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein ubiquitination plays a vital role in controlling the degradation of intracellular proteins and in regulating cell signaling pathways. Functionally, E3 ubiquitin ligases control the transfer of ubiquitin to the target substrates. As a major family of ubiquitin E3 ligases, the structural assembly of RING E3 ligases required to exert their ubiquitin E3 ligase activity remains poorly defined. Here, we solved the crystal structure of the coiled-coil domain of TRIM75, a member of the RING E3 ligase family, which showed that two disulfide bonds stabilize two antiparallel dimers at a small crossing angle. This tetrameric conformation confers two close RING domains on the same side to form a dimer. Furthermore, this architecture allows the RING dimer to present ubiquitin to a substrate on the same side. Overall, this structure reveals a disulfide bond-mediated unique tetramer architecture and provides a tetrameric structural model through which E3 ligases exert their function.

-	~~Authors~~:	+	Structural studies of the coiled-coil domain of TRIM75 reveal a tetramer architecture facilitating its E3 ligase complex.,Lou X, Ma B, Zhuang Y, Xiao X, Minze LJ, Xing J, Zhang Z, Li XC Comput Struct Biotechnol J. 2022 Sep 5;20:4921-4929. doi: , 10.1016/j.csbj.2022.08.069. eCollection 2022. PMID:36147661<ref>PMID:36147661</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7ug2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Li XC]]
		+	[[Category: Lou XH]]
		+	[[Category: Ma BB]]
		+	[[Category: Zhuang Y]]

OCA at 09:02, 6 April 2022

OCA — Wed, 06 Apr 2022 09:02:46 GMT

←Older revision		Revision as of 09:02, 6 April 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ug2 is ON HOLD	+	The entry 7ug2 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7ug2" [edit=sysop:move=sysop]

OCA — Wed, 30 Mar 2022 09:36:34 GMT

Protected "7ug2" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:36, 30 March 2022

OCA: New page: '''Unreleased structure''' The entry 7ug2 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 30 Mar 2022 09:36:33 GMT

New page: '''Unreleased structure''' The entry 7ug2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ug2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]