7ug5 - Revision history

OCA at 09:52, 25 October 2023

OCA — Wed, 25 Oct 2023 09:52:44 GMT

←Older revision		Revision as of 09:52, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7ug5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UG5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ug5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UG5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=N6I:(3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one'>N6I</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=N6I:(3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one'>N6I</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ug5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ug5 OCA], [https://pdbe.org/7ug5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ug5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ug5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ug5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ug5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ug5 OCA], [https://pdbe.org/7ug5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ug5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ug5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ug5 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:21, 7 April 2023

OCA — Fri, 07 Apr 2023 06:21:26 GMT

←Older revision		Revision as of 06:21, 7 April 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7ug5 is ~~ON HOLD until Paper Publication~~	+	==Second bromodomain of BRD3 liganded with BMS-536924==
-		+	<StructureSection load='7ug5' size='340' side='right'caption='[[7ug5]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~: ~~Schonbrunn~~, E., ~~Bikowitz~~, M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7ug5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UG5 FirstGlance]. <br>
-	~~Description~~: ~~Second bromodomain of~~ BRD3 ~~liganded~~ with ~~BMS~~-~~536924~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=N6I:(3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one'>N6I</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ug5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ug5 OCA], [https://pdbe.org/7ug5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ug5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ug5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ug5 ProSAT]</span></td></tr>
-	[[Category: ~~Schonbrunn, E~~]]	+	</table>
-	[[Category: Bikowitz, M]]	+	== Disease ==
		+	[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Bikowitz M]]
		+	[[Category: Schonbrunn E]]

OCA at 06:44, 22 June 2022

OCA — Wed, 22 Jun 2022 06:44:03 GMT

←Older revision		Revision as of 06:44, 22 June 2022
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	Description: Second bromodomain of BRD3 liganded with BMS-536924		Description: Second bromodomain of BRD3 liganded with BMS-536924
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Bikowitz, M]]
	[[Category: Schonbrunn, E]]		[[Category: Schonbrunn, E]]
		+	[[Category: Bikowitz, M]]

OCA: Protected "7ug5" [edit=sysop:move=sysop]

OCA — Wed, 30 Mar 2022 09:36:40 GMT

Protected "7ug5" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:36, 30 March 2022

OCA: New page: '''Unreleased structure''' The entry 7ug5 is ON HOLD until Paper Publication Authors: Schonbrunn, E., Bikowitz, M. Description: Second bromodomain of BRD3 liganded with BMS-536924 [[Ca...

OCA — Wed, 30 Mar 2022 09:36:39 GMT

New page: '''Unreleased structure''' The entry 7ug5 is ON HOLD until Paper Publication Authors: Schonbrunn, E., Bikowitz, M. Description: Second bromodomain of BRD3 liganded with BMS-536924 [[Ca...

New page

'''Unreleased structure'''

The entry 7ug5 is ON HOLD until Paper Publication

Authors: Schonbrunn, E., Bikowitz, M.

Description: Second bromodomain of BRD3 liganded with BMS-536924
[[Category: Unreleased Structures]]
[[Category: Bikowitz, M]]
[[Category: Schonbrunn, E]]