7ulg - Revision history

OCA at 09:55, 25 October 2023

OCA — Wed, 25 Oct 2023 09:55:01 GMT

←Older revision		Revision as of 09:55, 25 October 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7ulg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ULG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ULG FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ulg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ULG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ULG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.57Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ulg OCA], [https://pdbe.org/7ulg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ulg RCSB], [https://www.ebi.ac.uk/pdbsum/7ulg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ulg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ulg OCA], [https://pdbe.org/7ulg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ulg RCSB], [https://www.ebi.ac.uk/pdbsum/7ulg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ulg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:23, 3 May 2023

OCA — Wed, 03 May 2023 07:23:58 GMT

←Older revision		Revision as of 07:23, 3 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7ulg is ~~ON HOLD until Paper Publication~~	+	==recombinant alpha cobra toxin==
-		+	<StructureSection load='7ulg' size='340' side='right'caption='[[7ulg]], [[Resolution\|resolution]] 1.57Å' scene=''>
-	~~Authors~~: Xu, J., ~~Lei~~, X., ~~Chen~~, L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7ulg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ULG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ULG FirstGlance]. <br>
-	~~Description~~: ~~recombinant~~ alpha ~~cobra toxin~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ulg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ulg OCA], [https://pdbe.org/7ulg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ulg RCSB], [https://www.ebi.ac.uk/pdbsum/7ulg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ulg ProSAT]</span></td></tr>
-	[[Category: ~~Xu, J~~]]	+	</table>
-	[[Category: Lei, X]]	+	== Function ==
-	[[Category: ~~Chen, L~~]]	+	[https://www.uniprot.org/uniprot/3L21_NAJKA 3L21_NAJKA] Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM) (PubMed:18381281, PubMed:9305882, PubMed:22223648). Also inhibits GABA(A) channels (PubMed:26221036). Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits (IC(50)=485 nM), alpha-5-beta-3-gamma-2 (GABRA5-GABRB3-GABRG2) subunits (IC(50)=635 nM), and alpha-2-beta-3-gamma-2 (GABRA2-GABRB3-GABRG2) subunits (IC(50)=1099 nM) (activated by 10 uM GABA) (PubMed:26221036).<ref>PMID:18381281</ref> <ref>PMID:22223648</ref> <ref>PMID:26221036</ref> <ref>PMID:30025921</ref> Homodimer: binds with high affinity (but lower than the monomeric form) to muscular (IC(50)=9.7 nM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (IC(50)=1370 nM) (PubMed:22223648). However, it acquires (compared to the monomeric form) the capacity to block alpha-3/beta-2 (CHRNA3/CHRNB2) nAChRs (PubMed:18381281).<ref>PMID:18381281</ref> <ref>PMID:22223648</ref> Heterodimer with cytotoxin 3 (AC P01446): is slightly more active than the homodimer in inhibiting alpha-7/CHRNA7 nAChR and is considerably more active in blocking the alpha-3-beta-2/CHRNA3-CHRNB2 nAChR.<ref>PMID:22223648</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Naja kaouthia]]
		+	[[Category: Chen L]]
		+	[[Category: Lei X]]
		+	[[Category: Xu J]]

OCA at 04:45, 12 May 2022

OCA — Thu, 12 May 2022 04:45:08 GMT

←Older revision		Revision as of 04:45, 12 May 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ulg is ON HOLD	+	The entry 7ulg is ON HOLD until Paper Publication

	Authors: Xu, J., Lei, X., Chen, L.		Authors: Xu, J., Lei, X., Chen, L.

OCA: Protected "7ulg" [edit=sysop:move=sysop]

OCA — Wed, 13 Apr 2022 08:35:30 GMT

Protected "7ulg" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:35, 13 April 2022

OCA: New page: '''Unreleased structure''' The entry 7ulg is ON HOLD Authors: Xu, J., Lei, X., Chen, L. Description: recombinant alpha cobra toxin Category: Unreleased Structures [[Category: Xu, J...

OCA — Wed, 13 Apr 2022 08:35:29 GMT

New page: '''Unreleased structure''' The entry 7ulg is ON HOLD Authors: Xu, J., Lei, X., Chen, L. Description: recombinant alpha cobra toxin Category: Unreleased Structures [[Category: Xu, J...

New page

'''Unreleased structure'''

The entry 7ulg is ON HOLD

Authors: Xu, J., Lei, X., Chen, L.

Description: recombinant alpha cobra toxin
[[Category: Unreleased Structures]]
[[Category: Xu, J]]
[[Category: Lei, X]]
[[Category: Chen, L]]