7umc - Revision history

OCA at 06:45, 8 September 2022

OCA — Thu, 08 Sep 2022 06:45:49 GMT

←Older revision		Revision as of 06:45, 8 September 2022
Line 3:		Line 3:
	<StructureSection load='7umc' size='340' side='right'caption='[[7umc]]' scene=''>		<StructureSection load='7umc' size='340' side='right'caption='[[7umc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7umc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umc OCA], [https://pdbe.org/7umc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umc RCSB], [https://www.ebi.ac.uk/pdbsum/7umc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umc ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umc OCA], [https://pdbe.org/7umc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umc RCSB], [https://www.ebi.ac.uk/pdbsum/7umc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umc ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dengue virus, a single-stranded positive sense RNA virus, is the most prevalent mosquito-borne pathogen in the world. Like all RNA viruses, it uses conserved structural elements within its genome to control essential replicative steps. A 70 nucleotides stem-loop RNA structure (called SLA) found at the 5'-end of the genome of all flaviviruses, functions as the promoter for viral replication. This highly conserved structure interacts with the viral polymerase NS5 to initiate RNA synthesis. Here we report the NMR structure of a monomeric SLA from Dengue virus serotype 1, assembled to high-resolution from independently folded structural elements. The DENV1 SLA has an L-shape structure, where the top and side helices are coaxially-stacked and the bottom helix is roughly perpendicular to them. Because the sequence is highly conserved among different flavivirus genomes, it is likely that the three-dimensional fold and local structure of SLA are also conserved among flaviviruses and required for efficient replication. This work provides structural insight into the Dengue promoter and provides the foundation for the discovery of new antiviral drugs that target this essential replicative step.
		+
		+	Structure of the Dengue Virus RNA Promoter.,Sun YT, Varani G RNA. 2022 Jun 24. pii: rna.079197.122. doi: 10.1261/rna.079197.122. PMID:35750488<ref>PMID:35750488</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7umc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dengue virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sun YT]]		[[Category: Sun YT]]
	[[Category: Varani G]]		[[Category: Varani G]]

OCA at 11:11, 31 August 2022

OCA — Wed, 31 Aug 2022 11:11:08 GMT

←Older revision		Revision as of 11:11, 31 August 2022
Line 1:		Line 1:

	==DENV1 SLA RNA (DenvSLATL)==		==DENV1 SLA RNA (DenvSLATL)==
-	<StructureSection load='7umc' size='340' side='right'caption='[[7umc~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='7umc' size='340' side='right'caption='[[7umc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[7umc]] is a 1 chain structure.~~ Full ~~experimental~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMC FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umc OCA], [https://pdbe.org/7umc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umc RCSB], [https://www.ebi.ac.uk/pdbsum/7umc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umc ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umc OCA], [https://pdbe.org/7umc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umc RCSB], [https://www.ebi.ac.uk/pdbsum/7umc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umc ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Dengue virus, a single-stranded positive sense RNA virus, is the most prevalent mosquito-borne pathogen in the world. Like all RNA viruses, it uses conserved structural elements within its genome to control essential replicative steps. A 70 nucleotides stem-loop RNA structure (called SLA) found at the 5'-end of the genome of all flaviviruses, functions as the promoter for viral replication. This highly conserved structure interacts with the viral polymerase NS5 to initiate RNA synthesis. Here we report the NMR structure of a monomeric SLA from Dengue virus serotype 1, assembled to high-resolution from independently folded structural elements. The DENV1 SLA has an L-shape structure, where the top and side helices are coaxially-stacked and the bottom helix is roughly perpendicular to them. Because the sequence is highly conserved among different flavivirus genomes, it is likely that the three-dimensional fold and local structure of SLA are also conserved among flaviviruses and required for efficient replication. This work provides structural insight into the Dengue promoter and provides the foundation for the discovery of new antiviral drugs that target this essential replicative step.
-
-	Structure of the Dengue Virus RNA Promoter.,Sun YT, Varani G RNA. 2022 Jun 24. pii: rna.079197.122. doi: 10.1261/rna.079197.122. PMID:35750488<ref>PMID:35750488</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 7umc" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Structural genomic]]~~	+	[[Category: Sun YT]]
-	[[Category: Sun~~, Y T~~]]	+	[[Category: Varani G]]
-	[[Category: Varani, G]]	+
-	~~[[Category: 5' utr]]~~	+
-	~~[[Category: Flavivirus]]~~	+
-	~~[[Category: Ns5 promoter]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Sla]]~~	+
-	~~[[Category: Viral replication~~]]	+

OCA at 05:15, 25 August 2022

OCA — Thu, 25 Aug 2022 05:15:02 GMT

←Older revision		Revision as of 05:15, 25 August 2022
Line 1:		Line 1:

	==DENV1 SLA RNA (DenvSLATL)==		==DENV1 SLA RNA (DenvSLATL)==
-	<StructureSection load='7umc' size='340' side='right'caption='[[7umc]]' scene=''>	+	<StructureSection load='7umc' size='340' side='right'caption='[[7umc]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7umc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umc OCA], [https://pdbe.org/7umc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umc RCSB], [https://www.ebi.ac.uk/pdbsum/7umc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umc ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umc OCA], [https://pdbe.org/7umc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umc RCSB], [https://www.ebi.ac.uk/pdbsum/7umc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umc ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dengue virus, a single-stranded positive sense RNA virus, is the most prevalent mosquito-borne pathogen in the world. Like all RNA viruses, it uses conserved structural elements within its genome to control essential replicative steps. A 70 nucleotides stem-loop RNA structure (called SLA) found at the 5'-end of the genome of all flaviviruses, functions as the promoter for viral replication. This highly conserved structure interacts with the viral polymerase NS5 to initiate RNA synthesis. Here we report the NMR structure of a monomeric SLA from Dengue virus serotype 1, assembled to high-resolution from independently folded structural elements. The DENV1 SLA has an L-shape structure, where the top and side helices are coaxially-stacked and the bottom helix is roughly perpendicular to them. Because the sequence is highly conserved among different flavivirus genomes, it is likely that the three-dimensional fold and local structure of SLA are also conserved among flaviviruses and required for efficient replication. This work provides structural insight into the Dengue promoter and provides the foundation for the discovery of new antiviral drugs that target this essential replicative step.
		+
		+	Structure of the Dengue Virus RNA Promoter.,Sun YT, Varani G RNA. 2022 Jun 24. pii: rna.079197.122. doi: 10.1261/rna.079197.122. PMID:35750488<ref>PMID:35750488</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7umc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Sun YT]]	+	[[Category: Structural genomic]]
-	[[Category: Varani G]]	+	[[Category: Sun, Y T]]
		+	[[Category: Varani, G]]
		+	[[Category: 5' utr]]
		+	[[Category: Flavivirus]]
		+	[[Category: Ns5 promoter]]
		+	[[Category: Rna]]
		+	[[Category: Sla]]
		+	[[Category: Viral replication]]

OCA at 16:14, 6 July 2022

OCA — Wed, 06 Jul 2022 16:14:41 GMT

←Older revision		Revision as of 16:14, 6 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7umc ~~is ON HOLD until Paper Publication~~	+	==DENV1 SLA RNA (DenvSLATL)==
-		+	<StructureSection load='7umc' size='340' side='right'caption='[[7umc]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMC FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umc OCA], [https://pdbe.org/7umc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umc RCSB], [https://www.ebi.ac.uk/pdbsum/7umc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umc ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Sun YT]]
		+	[[Category: Varani G]]

OCA at 04:45, 12 May 2022

OCA — Thu, 12 May 2022 04:45:36 GMT

←Older revision		Revision as of 04:45, 12 May 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7umc is ON HOLD	+	The entry 7umc is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7umc" [edit=sysop:move=sysop]

OCA — Wed, 13 Apr 2022 08:36:44 GMT

Protected "7umc" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:36, 13 April 2022

OCA: New page: '''Unreleased structure''' The entry 7umc is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Apr 2022 08:36:43 GMT

New page: '''Unreleased structure''' The entry 7umc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7umc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]