7umx - Revision history

OCA at 10:11, 16 August 2023

OCA — Wed, 16 Aug 2023 10:11:49 GMT

←Older revision		Revision as of 10:11, 16 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7umx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMX FirstGlance]. <br>		<table><tr><td colspan='2'>[[7umx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NQF:(2E)-3-[(7R)-7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl]-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]prop-2-enamide'>NQF</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.39Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NQF:(2E)-3-[(7R)-7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl]-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]prop-2-enamide'>NQF</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umx OCA], [https://pdbe.org/7umx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umx RCSB], [https://www.ebi.ac.uk/pdbsum/7umx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umx OCA], [https://pdbe.org/7umx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umx RCSB], [https://www.ebi.ac.uk/pdbsum/7umx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umx ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 7umx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7umx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures\|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:22, 15 February 2023

OCA — Wed, 15 Feb 2023 10:22:24 GMT

←Older revision		Revision as of 10:22, 15 February 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7umx is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Acinetobacter baumannii FabI in complex with NAD and (R,E)-3-(7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)acrylamide==
		+	<StructureSection load='7umx' size='340' side='right'caption='[[7umx]], [[Resolution\|resolution]] 2.39Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7umx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NQF:(2E)-3-[(7R)-7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl]-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]prop-2-enamide'>NQF</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umx OCA], [https://pdbe.org/7umx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umx RCSB], [https://www.ebi.ac.uk/pdbsum/7umx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umx ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/D0CAD5_ACIB2 D0CAD5_ACIB2]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	[This corrects the article DOI: 10.1021/acscentsci.2c00598.].

-	~~Authors: Hajian~~, B.	+	Correction to "An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections".,Parker EN, Cain BN, Hajian B, Ulrich RJ, Geddes EJ, Barkho S, Lee HY, Williams JD, Raynor M, Caridha D, Zaino A, Rohde JM, Zak M, Shekhar M, Munoz KA, Rzasa KM, Temple ER, Hunt D, Jin X, Vuong C, Pannone K, Kelly AM, Mulligan MP, Lee KK, Lau GW, Hung DT, Hergenrother PJ ACS Cent Sci. 2022 Sep 28;8(9):1362. doi: 10.1021/acscentsci.2c00969. Epub 2022 , Sep 6. PMID:36188352<ref>PMID:36188352</ref>

-	~~Description: Crystal structure~~ of ~~Acinetobacter baumannii FabI in complex with NAD and (R,E)~~-3-~~(7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido~~[~~2,3-b~~]~~azepin-3-yl)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)acrylamide~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Hajian, B]]	+	<div class="pdbe-citations 7umx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Acinetobacter baumannii]]
		+	[[Category: Large Structures]]
		+	[[Category: Hajian B]]

OCA at 08:59, 18 May 2022

OCA — Wed, 18 May 2022 08:59:59 GMT

←Older revision		Revision as of 08:59, 18 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7umx is ON HOLD	+	The entry 7umx is ON HOLD until Paper Publication

	Authors: Hajian, B.		Authors: Hajian, B.

OCA: Protected "7umx" [edit=sysop:move=sysop]

OCA — Thu, 21 Apr 2022 01:34:53 GMT

Protected "7umx" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:34, 21 April 2022

OCA: New page: '''Unreleased structure''' The entry 7umx is ON HOLD Authors: Hajian, B. Description: Crystal structure of Acinetobacter baumannii FabI in complex with NAD and (R,E)-3-(7-amino-8-oxo-6...

OCA — Thu, 21 Apr 2022 01:34:52 GMT

New page: '''Unreleased structure''' The entry 7umx is ON HOLD Authors: Hajian, B. Description: Crystal structure of Acinetobacter baumannii FabI in complex with NAD and (R,E)-3-(7-amino-8-oxo-6...

New page

'''Unreleased structure'''

The entry 7umx is ON HOLD

Authors: Hajian, B.

Description: Crystal structure of Acinetobacter baumannii FabI in complex with NAD and (R,E)-3-(7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)acrylamide
[[Category: Unreleased Structures]]
[[Category: Hajian, B]]