7umy - Revision history

OCA at 10:11, 16 August 2023

OCA — Wed, 16 Aug 2023 10:11:51 GMT

←Older revision		Revision as of 10:11, 16 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7umy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMY FirstGlance]. <br>		<table><tr><td colspan='2'>[[7umy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NUC:(2E)-3-[(7S)-7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl]-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]prop-2-enamide'>NUC</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.74Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NUC:(2E)-3-[(7S)-7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl]-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]prop-2-enamide'>NUC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umy OCA], [https://pdbe.org/7umy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umy RCSB], [https://www.ebi.ac.uk/pdbsum/7umy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umy OCA], [https://pdbe.org/7umy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umy RCSB], [https://www.ebi.ac.uk/pdbsum/7umy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umy ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 7umy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7umy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures\|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:22, 15 February 2023

OCA — Wed, 15 Feb 2023 10:22:26 GMT

←Older revision		Revision as of 10:22, 15 February 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7umy is ~~ON HOLD~~	+	==Crystal structure of Acinetobacter baumannii FabI in complex with NAD and Fabimycin ((S,E)-3-(7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)acrylamide)==
		+	<StructureSection load='7umy' size='340' side='right'caption='[[7umy]], [[Resolution\|resolution]] 2.74Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7umy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UMY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NUC:(2E)-3-[(7S)-7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl]-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]prop-2-enamide'>NUC</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7umy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7umy OCA], [https://pdbe.org/7umy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7umy RCSB], [https://www.ebi.ac.uk/pdbsum/7umy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7umy ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/D0CAD5_ACIB2 D0CAD5_ACIB2]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	[This corrects the article DOI: 10.1021/acscentsci.2c00598.].

-	~~Authors: Hajian~~, B.	+	Correction to "An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections".,Parker EN, Cain BN, Hajian B, Ulrich RJ, Geddes EJ, Barkho S, Lee HY, Williams JD, Raynor M, Caridha D, Zaino A, Rohde JM, Zak M, Shekhar M, Munoz KA, Rzasa KM, Temple ER, Hunt D, Jin X, Vuong C, Pannone K, Kelly AM, Mulligan MP, Lee KK, Lau GW, Hung DT, Hergenrother PJ ACS Cent Sci. 2022 Sep 28;8(9):1362. doi: 10.1021/acscentsci.2c00969. Epub 2022 , Sep 6. PMID:36188352<ref>PMID:36188352</ref>

-	~~Description: Crystal structure~~ of ~~Acinetobacter baumannii FabI in complex with NAD and Fabimycin ((~~S~~,E)~~-3-~~(7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido~~[~~2,3-b~~]~~azepin-3-yl)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)acrylamide)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Hajian, B]]	+	<div class="pdbe-citations 7umy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Acinetobacter baumannii]]
		+	[[Category: Large Structures]]
		+	[[Category: Hajian B]]

OCA: Protected "7umy" [edit=sysop:move=sysop]

OCA — Thu, 21 Apr 2022 01:34:55 GMT

Protected "7umy" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:34, 21 April 2022

OCA: New page: '''Unreleased structure''' The entry 7umy is ON HOLD Authors: Hajian, B. Description: Crystal structure of Acinetobacter baumannii FabI in complex with NAD and Fabimycin ((S,E)-3-(7-am...

OCA — Thu, 21 Apr 2022 01:34:54 GMT

New page: '''Unreleased structure''' The entry 7umy is ON HOLD Authors: Hajian, B. Description: Crystal structure of Acinetobacter baumannii FabI in complex with NAD and Fabimycin ((S,E)-3-(7-am...

New page

'''Unreleased structure'''

The entry 7umy is ON HOLD

Authors: Hajian, B.

Description: Crystal structure of Acinetobacter baumannii FabI in complex with NAD and Fabimycin ((S,E)-3-(7-amino-8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)acrylamide)
[[Category: Unreleased Structures]]
[[Category: Hajian, B]]