7un7 - Revision history

OCA at 09:55, 25 October 2023

OCA — Wed, 25 Oct 2023 09:55:20 GMT

←Older revision		Revision as of 09:55, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7un7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UN7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7un7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UN7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.04Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7un7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7un7 OCA], [https://pdbe.org/7un7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7un7 RCSB], [https://www.ebi.ac.uk/pdbsum/7un7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7un7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7un7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7un7 OCA], [https://pdbe.org/7un7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7un7 RCSB], [https://www.ebi.ac.uk/pdbsum/7un7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7un7 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:41, 29 March 2023

OCA — Wed, 29 Mar 2023 06:41:30 GMT

←Older revision		Revision as of 06:41, 29 March 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7un7 is ~~ON HOLD~~	+	==DNA Polymerase lambda in complex with a 1nt microhomology substrate==
		+	<StructureSection load='7un7' size='340' side='right'caption='[[7un7]], [[Resolution\|resolution]] 2.04Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7un7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UN7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7un7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7un7 OCA], [https://pdbe.org/7un7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7un7 RCSB], [https://www.ebi.ac.uk/pdbsum/7un7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7un7 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The double-strand break (DSB) repair pathway called microhomology-mediated end-joining (MMEJ) is thought to be dependent on DNA polymerase theta (Poltheta) and occur independently of nonhomologous end-joining (NHEJ) factors. An unresolved question is whether MMEJ is facilitated by a single Poltheta-mediated end-joining pathway or consists of additional undiscovered pathways. We find that human X-family Pollambda, which functions in NHEJ, additionally exhibits robust MMEJ activity like Poltheta. Pollambda promotes MMEJ in mammalian cells independently of essential NHEJ factors LIG4/XRCC4 and Poltheta, which reveals a distinct Pollambda-dependent MMEJ mechanism. X-ray crystallography employing in situ photo-induced DSB formation captured Pollambda in the act of stabilizing a microhomology-mediated DNA synapse with incoming nucleotide at 2.0 A resolution and reveals how Pollambda performs replication across a DNA synapse joined by minimal base-pairing. Last, we find that Pollambda is semisynthetic lethal with BRCA1 and BRCA2. Together, these studies indicate Pollambda MMEJ as a distinct DSB repair mechanism.

-	~~Authors~~:	+	Pollambda promotes microhomology-mediated end-joining.,Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert ML, Tredinnick T, Ozdemir AY, Kent T, Demidova EV, Arora S, Wilson SH, Pomerantz RT Nat Struct Mol Biol. 2023 Jan;30(1):107-114. doi: 10.1038/s41594-022-00895-4. , Epub 2022 Dec 19. PMID:36536104<ref>PMID:36536104</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7un7" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Jamsen JA]]

OCA at 05:30, 22 March 2023

OCA — Wed, 22 Mar 2023 05:30:34 GMT

←Older revision		Revision as of 05:30, 22 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7un7 is ON HOLD ~~until Paper Publication~~	+	The entry 7un7 is ON HOLD

	Authors:		Authors:

OCA at 09:00, 18 May 2022

OCA — Wed, 18 May 2022 09:00:18 GMT

←Older revision		Revision as of 09:00, 18 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7un7 is ON HOLD	+	The entry 7un7 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7un7" [edit=sysop:move=sysop]

OCA — Thu, 21 Apr 2022 01:35:23 GMT

Protected "7un7" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:35, 21 April 2022

OCA: New page: '''Unreleased structure''' The entry 7un7 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 21 Apr 2022 01:35:22 GMT

New page: '''Unreleased structure''' The entry 7un7 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7un7 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]