7unm - Revision history

OCA at 09:38, 14 February 2024

OCA — Wed, 14 Feb 2024 09:38:50 GMT

←Older revision		Revision as of 09:38, 14 February 2024
Line 1:		Line 1:

	==Human TMEM175 in an closed state==		==Human TMEM175 in an closed state==
-	<StructureSection load='7unm' size='340' side='right'caption='[[7unm]]' scene=''>	+	<StructureSection load='7unm' size='340' side='right'caption='[[7unm]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UNM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7unm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UNM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7unm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7unm OCA], [https://pdbe.org/7unm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7unm RCSB], [https://www.ebi.ac.uk/pdbsum/7unm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7unm ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.61Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7unm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7unm OCA], [https://pdbe.org/7unm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7unm RCSB], [https://www.ebi.ac.uk/pdbsum/7unm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7unm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry. TMEM175 defects result in unstable lysosomal pH, leading to decreased lysosomal catalytic activity, decreased glucocerebrosidase activity, impaired autophagosome clearance by the lysosome and decreased mitochondrial respiration (PubMed:28193887).<ref>PMID:28193887</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.<ref>PMID:26317472</ref> <ref>PMID:28723891</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Oh, S,~~ Hite, RK]]	+	[[Category: Hite RK]]
		+	[[Category: Oh S]]

OCA at 07:28, 29 June 2022

OCA — Wed, 29 Jun 2022 07:28:09 GMT

←Older revision		Revision as of 07:28, 29 June 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7unm ~~is ON HOLD until Paper Publication~~	+	==Human TMEM175 in an closed state==
-		+	<StructureSection load='7unm' size='340' side='right'caption='[[7unm]]' scene=''>
-	~~Authors~~: Oh, S., ~~Hite~~, R.K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UNM FirstGlance]. <br>
-	~~Description: Human TMEM175 in an closed state~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7unm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7unm OCA], [https://pdbe.org/7unm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7unm RCSB], [https://www.ebi.ac.uk/pdbsum/7unm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7unm ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Oh, S]]	+	__TOC__
-	~~[[Category:~~ Hite, ~~R.K~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Oh, S, Hite, RK]]

OCA: Protected "7unm" [edit=sysop:move=sysop]

OCA — Thu, 21 Apr 2022 01:35:58 GMT

Protected "7unm" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:35, 21 April 2022

OCA: New page: '''Unreleased structure''' The entry 7unm is ON HOLD until Paper Publication Authors: Oh, S., Hite, R.K. Description: Human TMEM175 in an closed state [[Category: Unreleased Structures...

OCA — Thu, 21 Apr 2022 01:35:57 GMT

New page: '''Unreleased structure''' The entry 7unm is ON HOLD until Paper Publication Authors: Oh, S., Hite, R.K. Description: Human TMEM175 in an closed state [[Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 7unm is ON HOLD until Paper Publication

Authors: Oh, S., Hite, R.K.

Description: Human TMEM175 in an closed state
[[Category: Unreleased Structures]]
[[Category: Oh, S]]
[[Category: Hite, R.K]]