7uql - Revision history

OCA at 09:55, 25 October 2023

OCA — Wed, 25 Oct 2023 09:55:54 GMT

←Older revision		Revision as of 09:55, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7uql]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Papaver_somniferum Papaver somniferum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UQL FirstGlance]. <br>		<table><tr><td colspan='2'>[[7uql]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Papaver_somniferum Papaver somniferum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UQL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uql OCA], [https://pdbe.org/7uql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uql RCSB], [https://www.ebi.ac.uk/pdbsum/7uql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uql ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uql OCA], [https://pdbe.org/7uql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uql RCSB], [https://www.ebi.ac.uk/pdbsum/7uql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uql ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:58, 2 March 2023

OCA — Thu, 02 Mar 2023 05:58:15 GMT

←Older revision		Revision as of 05:58, 2 March 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7uql is ~~ON HOLD until Paper~~ Publication	+	==Pathogenesis related 10-10 app from==
		+	<StructureSection load='7uql' size='340' side='right'caption='[[7uql]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7uql]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Papaver_somniferum Papaver somniferum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UQL FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uql OCA], [https://pdbe.org/7uql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uql RCSB], [https://www.ebi.ac.uk/pdbsum/7uql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uql ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers, which compose an internal secretory system associated with phloem throughout the plant. The contiguous latex includes an abundance of related proteins belonging to the pathogenesis-related (PR)10 family known collectively as major latex proteins (MLPs) and representing at least 35% of the total cellular protein content. Two latex MLP/PR10 proteins, thebaine synthase and neopione isomerase, have recently been shown to catalyze late steps in morphine biosynthesis previously assigned as spontaneous reactions. Using a combination of sucrose density-gradient fractionation-coupled proteomics, differential scanning fluorimetry, isothermal titration calorimetry, and X-ray crystallography, we show that the major latex proteins are a family of alkaloid-binding proteins that display altered conformation in the presence of certain ligands. Addition of MLP/PR10 proteins to yeast strains engineered with morphine biosynthetic genes from the plant significantly enhanced the conversion of salutaridine to morphinan alkaloids.

-	~~Authors:~~ Carr, S~~.C.~~, Ng, K.K.S.	+	Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation.,Ozber N, Carr SC, Morris JS, Liang S, Watkins JL, Caldo KM, Hagel JM, Ng KKS, Facchini PJ Nat Commun. 2022 Nov 9;13(1):6768. doi: 10.1038/s41467-022-34313-6. PMID:36351903<ref>PMID:36351903</ref>

-	~~Description: Pathogenesis related 10~~-~~10 app from~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Ng, K.K.S~~]]	+	<div class="pdbe-citations 7uql" style="background-color:#fffaf0;"></div>
-	[[Category: Carr~~, S.C~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Papaver somniferum]]
		+	[[Category: Carr SC]]
		+	[[Category: Ng KKS]]

OCA at 06:40, 25 May 2022

OCA — Wed, 25 May 2022 06:40:51 GMT

←Older revision		Revision as of 06:40, 25 May 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7uql is ON HOLD	+	The entry 7uql is ON HOLD until Paper Publication

	Authors: Carr, S.C., Ng, K.K.S.		Authors: Carr, S.C., Ng, K.K.S.

OCA: Protected "7uql" [edit=sysop:move=sysop]

OCA — Wed, 27 Apr 2022 10:27:20 GMT

Protected "7uql" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:27, 27 April 2022

OCA: New page: '''Unreleased structure''' The entry 7uql is ON HOLD Authors: Carr, S.C., Ng, K.K.S. Description: Pathogenesis related 10-10 app from Category: Unreleased Structures [[Category: Ng...

OCA — Wed, 27 Apr 2022 10:27:19 GMT

New page: '''Unreleased structure''' The entry 7uql is ON HOLD Authors: Carr, S.C., Ng, K.K.S. Description: Pathogenesis related 10-10 app from Category: Unreleased Structures [[Category: Ng...

New page

'''Unreleased structure'''

The entry 7uql is ON HOLD

Authors: Carr, S.C., Ng, K.K.S.

Description: Pathogenesis related 10-10 app from
[[Category: Unreleased Structures]]
[[Category: Ng, K.K.S]]
[[Category: Carr, S.C]]