7usc - Revision history

OCA at 07:46, 9 November 2022

OCA — Wed, 09 Nov 2022 07:46:37 GMT

←Older revision		Revision as of 07:46, 9 November 2022
Line 7:		Line 7:
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN]] Angelman syndrome.	+	[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN] Angelman syndrome.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN]] Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.<ref>PMID:9417078</ref> <ref>PMID:16260607</ref> <ref>PMID:19524508</ref> <ref>PMID:21107423</ref>	+	[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN] Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.<ref>PMID:9417078</ref> <ref>PMID:16260607</ref> <ref>PMID:19524508</ref> <ref>PMID:21107423</ref>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:38, 21 September 2022

OCA — Wed, 21 Sep 2022 07:38:47 GMT

←Older revision		Revision as of 07:38, 21 September 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7usc is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of WAVE Regulatory Complex==
-		+	<StructureSection load='7usc' size='340' side='right'caption='[[7usc]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7usc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7USC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7USC FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7usc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7usc OCA], [https://pdbe.org/7usc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7usc RCSB], [https://www.ebi.ac.uk/pdbsum/7usc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7usc ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN]] Angelman syndrome.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN]] Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.<ref>PMID:9417078</ref> <ref>PMID:16260607</ref> <ref>PMID:19524508</ref> <ref>PMID:21107423</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Chen B]]
		+	[[Category: Chowdhury S]]
		+	[[Category: Ding B]]
		+	[[Category: Yang S]]

OCA at 04:46, 12 May 2022

OCA — Thu, 12 May 2022 04:46:39 GMT

←Older revision		Revision as of 04:46, 12 May 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7usc is ON HOLD	+	The entry 7usc is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7usc" [edit=sysop:move=sysop]

OCA — Wed, 04 May 2022 11:32:38 GMT

Protected "7usc" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:32, 4 May 2022

OCA: New page: '''Unreleased structure''' The entry 7usc is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 May 2022 11:32:37 GMT

New page: '''Unreleased structure''' The entry 7usc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7usc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]