OCA at 10:38, 30 November 2022

OCA — Wed, 30 Nov 2022 10:38:32 GMT

←Older revision		Revision as of 10:38, 30 November 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7ux2 is ~~ON HOLD until Paper Publication~~	+	==cryo-EM structure of the Raptor-TFEB-Rag-Ragulator complex==
-		+	<StructureSection load='7ux2' size='340' side='right'caption='[[7ux2]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7ux2]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UX2 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ux2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ux2 OCA], [https://pdbe.org/7ux2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ux2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ux2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ux2 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RPTOR_HUMAN RPTOR_HUMAN] Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.<ref>PMID:12150925</ref> <ref>PMID:12150926</ref> <ref>PMID:23727834</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Cui Z]]
		+	[[Category: Hurley J]]

OCA at 06:22, 21 September 2022

OCA — Wed, 21 Sep 2022 06:22:00 GMT

←Older revision		Revision as of 06:22, 21 September 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ux2 is ON HOLD	+	The entry 7ux2 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7ux2" [edit=sysop:move=sysop]

OCA — Thu, 12 May 2022 04:51:24 GMT

Protected "7ux2" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:51, 12 May 2022

OCA: New page: '''Unreleased structure''' The entry 7ux2 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 12 May 2022 04:51:23 GMT

New page: '''Unreleased structure''' The entry 7ux2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ux2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7ux2 - Revision history

OCA at 10:38, 30 November 2022

OCA at 06:22, 21 September 2022

OCA: Protected "7ux2" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7ux2 is ON HOLD Authors: Description: Category: Unreleased Structures