7v0g - Revision history

OCA at 09:58, 25 October 2023

OCA — Wed, 25 Oct 2023 09:58:57 GMT

←Older revision		Revision as of 09:58, 25 October 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7v0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V0G FirstGlance]. <br>		<table><tr><td colspan='2'>[[7v0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V0G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.63Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v0g OCA], [https://pdbe.org/7v0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v0g RCSB], [https://www.ebi.ac.uk/pdbsum/7v0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v0g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v0g OCA], [https://pdbe.org/7v0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v0g RCSB], [https://www.ebi.ac.uk/pdbsum/7v0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v0g ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:13, 7 December 2022

OCA — Wed, 07 Dec 2022 08:13:15 GMT

←Older revision		Revision as of 08:13, 7 December 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7v0g is ~~ON HOLD until Paper Publication~~	+	==Structure of cAMP-dependent protein kinase using a MD-MX procedure, produced using 1.63 Angstrom data==
-		+	<StructureSection load='7v0g' size='340' side='right'caption='[[7v0g]], [[Resolution\|resolution]] 1.63Å' scene=''>
-	~~Authors~~: ~~Wych~~, D.C., ~~Aoto~~, P.C., ~~Wall~~, M.E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7v0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V0G FirstGlance]. <br>
-	~~Description~~: ~~Structure~~ of ~~cAMP~~-~~dependent protein kinase using~~ a MD-~~MX procedure~~, ~~produced using 1~~.~~63 Angstrom data~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v0g OCA], [https://pdbe.org/7v0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v0g RCSB], [https://www.ebi.ac.uk/pdbsum/7v0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v0g ProSAT]</span></td></tr>
-	[[Category: ~~Wall, M.E~~]]	+	</table>
-	[[Category: Aoto~~, P.C~~]]	+	== Function ==
-	[[Category: Wych~~, D.C~~]]	+	[https://www.uniprot.org/uniprot/KAPCA_MOUSE KAPCA_MOUSE] Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). TRPC1 activation by phosphorylation promotes Ca(2+) influx, essential for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Regulates negatively tight junction (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT).<ref>PMID:15340140</ref> <ref>PMID:19223768</ref> <ref>PMID:19560455</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Aoto PC]]
		+	[[Category: Wall ME]]
		+	[[Category: Wych DC]]

OCA at 16:29, 19 October 2022

OCA — Wed, 19 Oct 2022 16:29:23 GMT

←Older revision		Revision as of 16:29, 19 October 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7v0g is ON HOLD	+	The entry 7v0g is ON HOLD until Paper Publication

	Authors: Wych, D.C., Aoto, P.C., Wall, M.E.		Authors: Wych, D.C., Aoto, P.C., Wall, M.E.

OCA: Protected "7v0g" [edit=sysop:move=sysop]

OCA — Wed, 18 May 2022 09:06:33 GMT

Protected "7v0g" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:06, 18 May 2022

OCA: New page: '''Unreleased structure''' The entry 7v0g is ON HOLD Authors: Wych, D.C., Aoto, P.C., Wall, M.E. Description: Structure of cAMP-dependent protein kinase using a MD-MX procedure, produc...

OCA — Wed, 18 May 2022 09:06:32 GMT

New page: '''Unreleased structure''' The entry 7v0g is ON HOLD Authors: Wych, D.C., Aoto, P.C., Wall, M.E. Description: Structure of cAMP-dependent protein kinase using a MD-MX procedure, produc...

New page

'''Unreleased structure'''

The entry 7v0g is ON HOLD

Authors: Wych, D.C., Aoto, P.C., Wall, M.E.

Description: Structure of cAMP-dependent protein kinase using a MD-MX procedure, produced using 1.63 Angstrom data
[[Category: Unreleased Structures]]
[[Category: Wall, M.E]]
[[Category: Aoto, P.C]]
[[Category: Wych, D.C]]