7v8p - Revision history

OCA at 17:21, 29 November 2023

OCA — Wed, 29 Nov 2023 17:21:58 GMT

←Older revision		Revision as of 17:21, 29 November 2023
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	==Crystal Structure of the MukE dimer==		==Crystal Structure of the MukE dimer==
-	<StructureSection load='7v8p' size='340' side='right'caption='[[7v8p]]' scene=''>	+	<StructureSection load='7v8p' size='340' side='right'caption='[[7v8p]], [[Resolution\|resolution]] 2.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V8P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7v8p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V8P FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v8p OCA], [https://pdbe.org/7v8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v8p RCSB], [https://www.ebi.ac.uk/pdbsum/7v8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v8p ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.44Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v8p OCA], [https://pdbe.org/7v8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v8p RCSB], [https://www.ebi.ac.uk/pdbsum/7v8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v8p ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MUKE_SHIFL MUKE_SHIFL] Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.[HAMAP-Rule:MF_01802]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The SMC (structural maintenance of chromosomes) proteins are known to be involved in chromosome pairing or aggregation and play an important role in cell cycle and division. Different from SMC-ScpAB complex maintaining chromosome structure in most bacteria, the MukB-MukE-MukF complex is responsible for chromosome condensation in E. coli and some gamma-proteobacter. Though different models were proposed to illustrate the mechanism of how the MukBEF complex worked, the assembly of the MukBEF complex is a key. The MukE dimer interacted with the middle region of one MukF molecule, and was clamped by the N- and C-terminal domain of the latter, and then was involved in the interaction with the head domain of MukB. To reveal the structural basis of MukE involved in the dynamic equilibrium of potential different MukBEF assemblies, we determined the MukE structure at 2.44 A resolution. We found that the binding cavity for the alpha10, beta4 and beta5 of MukF (residues 296-327) in the MukE dimer has been occupied by the alpha9 and beta7 strand of MukE. We proposed that the highly dynamic C-terminal region (173-225) was important for the MukE-F assembly and then involved in the MukBEF complex formation.
		+
		+	Crystal structure of the chromosome partition protein MukE homodimer.,Qian JW, Wang XY, Deng K, Li DF, Guo L Biochem Biophys Res Commun. 2021 Dec 14;589:229-233. doi:, 10.1016/j.bbrc.2021.12.032. PMID:34929446<ref>PMID:34929446</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7v8p" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Shigella flexneri]]
	[[Category: Guo L]]		[[Category: Guo L]]
	[[Category: Qian JW]]		[[Category: Qian JW]]

OCA at 10:41, 5 January 2022

OCA — Wed, 05 Jan 2022 10:41:27 GMT

←Older revision		Revision as of 10:41, 5 January 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7v8p ~~is ON HOLD until Paper Publication~~	+	==Crystal Structure of the MukE dimer==
-		+	<StructureSection load='7v8p' size='340' side='right'caption='[[7v8p]]' scene=''>
-	~~Authors~~: ~~Qian~~, J.W., ~~Guo~~, L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V8P FirstGlance]. <br>
-	~~Description: Crystal Structure of the MukE dimer~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v8p OCA], [https://pdbe.org/7v8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v8p RCSB], [https://www.ebi.ac.uk/pdbsum/7v8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v8p ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Qian, J.W~~]]	+	__TOC__
-	[[Category: ~~Guo, L~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Guo L]]
		+	[[Category: Qian JW]]

OCA at 12:15, 29 December 2021

OCA — Wed, 29 Dec 2021 12:15:50 GMT

←Older revision		Revision as of 12:15, 29 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7v8p is ON HOLD	+	The entry 7v8p is ON HOLD until Paper Publication

	Authors: Qian, J.W., Guo, L.		Authors: Qian, J.W., Guo, L.

OCA: Protected "7v8p" [edit=sysop:move=sysop]

OCA — Wed, 08 Sep 2021 07:58:56 GMT

Protected "7v8p" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:58, 8 September 2021

OCA: New page: '''Unreleased structure''' The entry 7v8p is ON HOLD Authors: Qian, J.W., Guo, L. Description: Crystal Structure of the MukE dimer Category: Unreleased Structures [[Category: Qian,...

OCA — Wed, 08 Sep 2021 07:58:55 GMT

New page: '''Unreleased structure''' The entry 7v8p is ON HOLD Authors: Qian, J.W., Guo, L. Description: Crystal Structure of the MukE dimer Category: Unreleased Structures [[Category: Qian,...

New page

'''Unreleased structure'''

The entry 7v8p is ON HOLD

Authors: Qian, J.W., Guo, L.

Description: Crystal Structure of the MukE dimer
[[Category: Unreleased Structures]]
[[Category: Qian, J.W]]
[[Category: Guo, L]]