7v9h - Revision history

OCA at 19:42, 29 May 2024

OCA — Wed, 29 May 2024 19:42:38 GMT

←Older revision		Revision as of 19:42, 29 May 2024
Line 3:		Line 3:
	<StructureSection load='7v9h' size='340' side='right'caption='[[7v9h]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='7v9h' size='340' side='right'caption='[[7v9h]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[7v9h]] is a 1 chain structure.~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V9H FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V9H FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v9h OCA], [https://pdbe.org/7v9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v9h RCSB], [https://www.ebi.ac.uk/pdbsum/7v9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v9h ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.692Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v9h OCA], [https://pdbe.org/7v9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v9h RCSB], [https://www.ebi.ac.uk/pdbsum/7v9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v9h ProSAT]</span></td></tr>
	</table>		</table>
-	== Function ==
-	[[https://www.uniprot.org/uniprot/BEND3_MOUSE BEND3_MOUSE]] Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (By similarity). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (PubMed:25457167). Stimulates the ERCC6L translocase and ATPase activities (By similarity).[UniProtKB:Q5T5X7]<ref>PMID:25457167</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Bivalent genes are ready for activation upon the arrival of developmental cues. Here we report that BEND3 is a CpG island (CGI) binding protein enriched at regulatory elements. The cocrystal structure of BEND3 in complex with its target DNA revealed the structural basis for its DNA methylation-sensitive binding property. Mouse embryos ablated of Bend3 died at pre-gastrulation stage. Bend3 null ES cells exhibited severe defects in differentiation, during which hundreds of CGI-containing bivalent genes were prematurely activated. BEND3 is required for stable association of PRC2 complex at bivalent genes that are highly occupied by BEND3, suggesting a reining function of BEND3 in maintaining high level of H3K27me3 at these bivalent genes in ES cells to prevent them from premature activation in the forthcoming developmental stage.
-
-	Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation.,Zhang J, Zhang Y, You Q, Huang C, Zhang T, Wang M, Zhang T, Yang X, Xiong J, Li Y, Liu CP, Zhang Z, Xu RM, Zhu B Science. 2022 Feb 10:eabm0730. doi: 10.1126/science.abm0730. PMID:35143257<ref>PMID:35143257</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 7v9h" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huang, C]]	+	[[Category: Huang C]]
-	[[Category: Li, Y]]	+	[[Category: Li Y]]
-	[[Category: Liu~~, C P~~]]	+	[[Category: Liu CP]]
-	[[Category: Wang, M]]	+	[[Category: Wang M]]
-	[[Category: Xiong, J]]	+	[[Category: Xiong J]]
-	[[Category: Xu~~, R M~~]]	+	[[Category: Xu RM]]
-	[[Category: Yang, X]]	+	[[Category: Yang X]]
-	[[Category: You, Q]]	+	[[Category: You Q]]
-	[[Category: Zhang, J]]	+	[[Category: Zhang J]]
-	[[Category: Zhang, T]]	+	[[Category: Zhang T]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	[[Category: Zhang, Z]]	+	[[Category: Zhang Z]]
-	[[Category: Zhu, B]]	+	[[Category: Zhu B]]
-	~~[[Category: Dna binding protein~~]]	+

OCA at 08:47, 23 February 2022

OCA — Wed, 23 Feb 2022 08:47:10 GMT

←Older revision		Revision as of 08:47, 23 February 2022
Line 1:		Line 1:

	==The BEN3 domain of protein Bend3==		==The BEN3 domain of protein Bend3==
-	<StructureSection load='7v9h' size='340' side='right'caption='[[7v9h]]' scene=''>	+	<StructureSection load='7v9h' size='340' side='right'caption='[[7v9h]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V9H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7v9h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V9H FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v9h OCA], [https://pdbe.org/7v9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v9h RCSB], [https://www.ebi.ac.uk/pdbsum/7v9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v9h ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v9h OCA], [https://pdbe.org/7v9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v9h RCSB], [https://www.ebi.ac.uk/pdbsum/7v9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v9h ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/BEND3_MOUSE BEND3_MOUSE]] Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (By similarity). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (PubMed:25457167). Stimulates the ERCC6L translocase and ATPase activities (By similarity).[UniProtKB:Q5T5X7]<ref>PMID:25457167</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bivalent genes are ready for activation upon the arrival of developmental cues. Here we report that BEND3 is a CpG island (CGI) binding protein enriched at regulatory elements. The cocrystal structure of BEND3 in complex with its target DNA revealed the structural basis for its DNA methylation-sensitive binding property. Mouse embryos ablated of Bend3 died at pre-gastrulation stage. Bend3 null ES cells exhibited severe defects in differentiation, during which hundreds of CGI-containing bivalent genes were prematurely activated. BEND3 is required for stable association of PRC2 complex at bivalent genes that are highly occupied by BEND3, suggesting a reining function of BEND3 in maintaining high level of H3K27me3 at these bivalent genes in ES cells to prevent them from premature activation in the forthcoming developmental stage.
		+
		+	Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation.,Zhang J, Zhang Y, You Q, Huang C, Zhang T, Wang M, Zhang T, Yang X, Xiong J, Li Y, Liu CP, Zhang Z, Xu RM, Zhu B Science. 2022 Feb 10:eabm0730. doi: 10.1126/science.abm0730. PMID:35143257<ref>PMID:35143257</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7v9h" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huang C]]	+	[[Category: Huang, C]]
-	[[Category: Li Y]]	+	[[Category: Li, Y]]
-	[[Category: Liu CP]]	+	[[Category: Liu, C P]]
-	[[Category: Wang M]]	+	[[Category: Wang, M]]
-	[[Category: Xiong J]]	+	[[Category: Xiong, J]]
-	[[Category: Xu RM]]	+	[[Category: Xu, R M]]
-	[[Category: Yang X]]	+	[[Category: Yang, X]]
-	[[Category: You Q]]	+	[[Category: You, Q]]
-	[[Category: Zhang J]]	+	[[Category: Zhang, J]]
-	[[Category: Zhang T]]	+	[[Category: Zhang, T]]
-	[[Category: Zhang Y]]	+	[[Category: Zhang, Y]]
-	[[Category: Zhang Z]]	+	[[Category: Zhang, Z]]
-	[[Category: Zhu B]]	+	[[Category: Zhu, B]]
		+	[[Category: Dna binding protein]]

OCA at 10:19, 16 February 2022

OCA — Wed, 16 Feb 2022 10:19:20 GMT

←Older revision		Revision as of 10:19, 16 February 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 7v9h is ~~ON HOLD until Paper Publication~~	+	==The BEN3 domain of protein Bend3==
-		+	<StructureSection load='7v9h' size='340' side='right'caption='[[7v9h]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V9H FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v9h OCA], [https://pdbe.org/7v9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v9h RCSB], [https://www.ebi.ac.uk/pdbsum/7v9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v9h ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Huang C]]
		+	[[Category: Li Y]]
		+	[[Category: Liu CP]]
		+	[[Category: Wang M]]
		+	[[Category: Xiong J]]
		+	[[Category: Xu RM]]
		+	[[Category: Yang X]]
		+	[[Category: You Q]]
		+	[[Category: Zhang J]]
		+	[[Category: Zhang T]]
		+	[[Category: Zhang Y]]
		+	[[Category: Zhang Z]]
		+	[[Category: Zhu B]]

OCA at 12:16, 29 December 2021

OCA — Wed, 29 Dec 2021 12:16:42 GMT

←Older revision		Revision as of 12:16, 29 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7v9h is ON HOLD	+	The entry 7v9h is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7v9h" [edit=sysop:move=sysop]

OCA — Wed, 08 Sep 2021 08:00:06 GMT

Protected "7v9h" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:00, 8 September 2021

OCA: New page: '''Unreleased structure''' The entry 7v9h is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Sep 2021 08:00:04 GMT

New page: '''Unreleased structure''' The entry 7v9h is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7v9h is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]