OCA at 07:23, 9 November 2022

OCA — Wed, 09 Nov 2022 07:23:08 GMT

←Older revision		Revision as of 07:23, 9 November 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7vfp is ~~ON HOLD until 2023~~-12-13	+	==Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with heme and single ATP==
		+	<StructureSection load='7vfp' size='340' side='right'caption='[[7vfp]], [[Resolution\|resolution]] 4.03Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7vfp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VFP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vfp OCA], [https://pdbe.org/7vfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vfp RCSB], [https://www.ebi.ac.uk/pdbsum/7vfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vfp ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CCMA_ECOLI CCMA_ECOLI] Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytochromes c use heme as a cofactor to carry electrons in respiration and photosynthesis. The cytochrome c maturation system I, consisting of eight membrane proteins (CcmABCDEFGH), results in the attachment of heme to cysteine residues of cytochrome c proteins. Since all c-type cytochromes are periplasmic, heme is first transported to a periplasmic heme chaperone, CcmE. A large membrane complex, CcmABCD has been proposed to carry out this transport and linkage to CcmE, yet the structural basis and mechanisms underlying the process are unknown. We describe high resolution cryo-EM structures of CcmABCD in an unbound form, in complex with inhibitor AMP-PNP, and in complex with ATP and heme. We locate the ATP-binding site in CcmA and the heme-binding site in CcmC. Based on our structures combined with functional studies, we propose a hypothetic model of heme trafficking, heme transfer to CcmE, and ATP-dependent release of holoCcmE from CcmABCD. CcmABCD represents an ABC transporter complex using the energy of ATP hydrolysis for the transfer of heme from one binding partner (CcmC) to another (CcmE).

-	~~Authors~~:	+	Structures of the CcmABCD heme release complex at multiple states.,Li J, Zheng W, Gu M, Han L, Luo Y, Yu K, Sun M, Zong Y, Ma X, Liu B, Lowder EP, Mendez DL, Kranz RG, Zhang K, Zhu J Nat Commun. 2022 Oct 28;13(1):6422. doi: 10.1038/s41467-022-34136-5. PMID:36307425<ref>PMID:36307425</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7vfp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Gu M]]
		+	[[Category: Li J]]
		+	[[Category: Zhang K]]
		+	[[Category: Zheng W]]
		+	[[Category: Zhu JP]]

OCA at 03:30, 25 August 2022

OCA — Thu, 25 Aug 2022 03:30:33 GMT

←Older revision		Revision as of 03:30, 25 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7vfp is ON HOLD until ~~Paper Publication~~	+	The entry 7vfp is ON HOLD until 2023-12-13

	Authors:		Authors:

OCA at 06:04, 29 June 2022

OCA — Wed, 29 Jun 2022 06:04:36 GMT

←Older revision		Revision as of 06:04, 29 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7vfp is ON HOLD	+	The entry 7vfp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 06:42, 25 May 2022

OCA — Wed, 25 May 2022 06:42:09 GMT

←Older revision		Revision as of 06:42, 25 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7vfp is ON HOLD ~~until Paper Publication~~	+	The entry 7vfp is ON HOLD

	Authors:		Authors:

OCA at 12:20, 29 December 2021

OCA — Wed, 29 Dec 2021 12:20:35 GMT

←Older revision		Revision as of 12:20, 29 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7vfp is ON HOLD	+	The entry 7vfp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7vfp" [edit=sysop:move=sysop]

OCA — Wed, 22 Sep 2021 05:44:27 GMT

Protected "7vfp" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:44, 22 September 2021

OCA: New page: '''Unreleased structure''' The entry 7vfp is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Sep 2021 05:44:26 GMT

New page: '''Unreleased structure''' The entry 7vfp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7vfp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]