7vgw - Revision history

OCA at 17:25, 29 November 2023

OCA — Wed, 29 Nov 2023 17:25:03 GMT

←Older revision		Revision as of 17:25, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7vgw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VGW FirstGlance]. <br>		<table><tr><td colspan='2'>[[7vgw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VGW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vgw OCA], [https://pdbe.org/7vgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vgw RCSB], [https://www.ebi.ac.uk/pdbsum/7vgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vgw ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vgw OCA], [https://pdbe.org/7vgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vgw RCSB], [https://www.ebi.ac.uk/pdbsum/7vgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vgw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:17, 8 September 2022

OCA — Thu, 08 Sep 2022 04:17:56 GMT

←Older revision		Revision as of 04:17, 8 September 2022
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	==Yeast gid10 with Pro-peptide==		==Yeast gid10 with Pro-peptide==
-	<StructureSection load='7vgw' size='340' side='right'caption='[[7vgw]]' scene=''>	+	<StructureSection load='7vgw' size='340' side='right'caption='[[7vgw]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VGW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7vgw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VGW FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vgw OCA], [https://pdbe.org/7vgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vgw RCSB], [https://www.ebi.ac.uk/pdbsum/7vgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vgw ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vgw OCA], [https://pdbe.org/7vgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vgw RCSB], [https://www.ebi.ac.uk/pdbsum/7vgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vgw ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cellular glucose level has to be tightly regulated by a variety of cellular processes. One of them is the degradation of gluconeogenic enzymes such as Fbp1, Icl1, Mdh2, and Pck1 by GID (glucose-induced degradation deficient) E3 ubiquitin ligase. The Gid4 component of the GID ligase complex is responsible for recognizing the N-terminal proline residue of the target substrates under normal conditions. However, an alternative N-recognin Gid10 controls the degradation process under stressed conditions. Although Gid10 shares a high sequence similarity with Gid4, their substrate specificities are quite different. Here, we report the structure of Gid10 from Saccharomyces cerevisiae in complex with Pro/N-degron, Pro-Tyr-Ile-Thr, which is almost identical to the sequence of the natural substrate Art2. Although Gid10 shares many structural features with the Gid4 protein from yeast and humans, the current structure explains the unique structural difference for the preference of bulky hydrophobic residue at the second position of Pro/N-degron. Therefore, this study provides a fundamental basis for understanding of the structural diversity and substrate specificity of recognition components in the GID E3 ligase complex involved in the Pro/N-degron pathway.
		+
		+	Crystal structure of yeast Gid10 in complex with Pro/N-degron.,Shin JS, Park SH, Kim L, Heo J, Song HK Biochem Biophys Res Commun. 2021 Dec 10;582:86-92. doi:, 10.1016/j.bbrc.2021.10.007. Epub 2021 Oct 6. PMID:34695755<ref>PMID:34695755</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7vgw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Saccharomyces cerevisiae]]
	[[Category: Heo J]]		[[Category: Heo J]]
	[[Category: Kim L]]		[[Category: Kim L]]

OCA at 18:06, 27 July 2022

OCA — Wed, 27 Jul 2022 18:06:09 GMT

←Older revision		Revision as of 18:06, 27 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7vgw ~~is ON HOLD until Paper Publication~~	+	==Yeast gid10 with Pro-peptide==
-		+	<StructureSection load='7vgw' size='340' side='right'caption='[[7vgw]]' scene=''>
-	~~Authors~~: ~~Shin, J~~.S., ~~Park, S~~.H., ~~Kim~~, L., ~~Heo, J~~., ~~Song, H~~.K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VGW FirstGlance]. <br>
-	~~Description: Yeast gid10 with Pro-peptide~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vgw OCA], [https://pdbe.org/7vgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vgw RCSB], [https://www.ebi.ac.uk/pdbsum/7vgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vgw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Park, S.H~~]]	+	__TOC__
-	[[Category: Kim, L]]	+	</StructureSection>
-	[[Category: ~~Heo, J~~]]	+	[[Category: Large Structures]]
-	[[Category: Shin~~, J.S~~]]	+	[[Category: Heo J]]
-	[[Category: Song~~, H.K~~]]	+	[[Category: Kim L]]
		+	[[Category: Park SH]]
		+	[[Category: Shin JS]]
		+	[[Category: Song HK]]

OCA at 12:21, 29 December 2021

OCA — Wed, 29 Dec 2021 12:21:12 GMT

←Older revision		Revision as of 12:21, 29 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7vgw is ON HOLD	+	The entry 7vgw is ON HOLD until Paper Publication

	Authors: Shin, J.S., Park, S.H., Kim, L., Heo, J., Song, H.K.		Authors: Shin, J.S., Park, S.H., Kim, L., Heo, J., Song, H.K.
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	Description: Yeast gid10 with Pro-peptide		Description: Yeast gid10 with Pro-peptide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Kim, L]]
-	[[Category: Song, H.K]]
	[[Category: Park, S.H]]		[[Category: Park, S.H]]
		+	[[Category: Kim, L]]
	[[Category: Heo, J]]		[[Category: Heo, J]]
	[[Category: Shin, J.S]]		[[Category: Shin, J.S]]
		+	[[Category: Song, H.K]]

OCA: Protected "7vgw" [edit=sysop:move=sysop]

OCA — Wed, 29 Sep 2021 07:53:02 GMT

Protected "7vgw" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:53, 29 September 2021

OCA: New page: '''Unreleased structure''' The entry 7vgw is ON HOLD Authors: Shin, J.S., Park, S.H., Kim, L., Heo, J., Song, H.K. Description: Yeast gid10 with Pro-peptide [[Category: Unreleased Stru...

OCA — Wed, 29 Sep 2021 07:53:01 GMT

New page: '''Unreleased structure''' The entry 7vgw is ON HOLD Authors: Shin, J.S., Park, S.H., Kim, L., Heo, J., Song, H.K. Description: Yeast gid10 with Pro-peptide [[Category: Unreleased Stru...

New page

'''Unreleased structure'''

The entry 7vgw is ON HOLD

Authors: Shin, J.S., Park, S.H., Kim, L., Heo, J., Song, H.K.

Description: Yeast gid10 with Pro-peptide
[[Category: Unreleased Structures]]
[[Category: Kim, L]]
[[Category: Song, H.K]]
[[Category: Park, S.H]]
[[Category: Heo, J]]
[[Category: Shin, J.S]]