OCA at 10:21, 14 December 2022

OCA — Wed, 14 Dec 2022 10:21:03 GMT

←Older revision		Revision as of 10:21, 14 December 2022
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	==Structure of SUR2B in complex with Mg-ATP/ADP==		==Structure of SUR2B in complex with Mg-ATP/ADP==
-	<StructureSection load='7vlr' size='340' side='right'caption='[[7vlr]]' scene=''>	+	<StructureSection load='7vlr' size='340' side='right'caption='[[7vlr]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VLR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7vlr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VLR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vlr OCA], [https://pdbe.org/7vlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vlr RCSB], [https://www.ebi.ac.uk/pdbsum/7vlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vlr ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vlr OCA], [https://pdbe.org/7vlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vlr RCSB], [https://www.ebi.ac.uk/pdbsum/7vlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vlr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ABCC9_RAT ABCC9_RAT] Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ATP-sensitive potassium channels (K(ATP)), composed of Kir6 and SUR subunits, convert the metabolic status of the cell into electrical signals. Pharmacological activation of SUR2- containing K(ATP) channels by class of small molecule drugs known as K(ATP) openers leads to hyperpolarization of excitable cells and to vasodilation. Thus, K(ATP) openers could be used to treat cardiovascular diseases. However, where these vasodilators bind to K(ATP) and how they activate the channel remains elusive. Here, we present cryo-EM structures of SUR2A and SUR2B subunits in complex with Mg-nucleotides and P1075 or levcromakalim, two chemically distinct K(ATP) openers that are specific to SUR2. Both P1075 and levcromakalim bind to a common site in the transmembrane domain (TMD) of the SUR2 subunit, which is between TMD1 and TMD2 and is embraced by TM10, TM11, TM12, TM14, and TM17. These K(ATP) openers synergize with Mg-nucleotides to stabilize SUR2 in the NBD-dimerized occluded state to activate the channel.
		+
		+	Structural identification of vasodilator binding sites on the SUR2 subunit.,Ding D, Wu JX, Duan X, Ma S, Lai L, Chen L Nat Commun. 2022 May 13;13(1):2675. doi: 10.1038/s41467-022-30428-y. PMID:35562524<ref>PMID:35562524</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7vlr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ABC transporter 3D structures\|ABC transporter 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Rattus norvegicus]]
	[[Category: Chen L]]		[[Category: Chen L]]
	[[Category: Ding D]]		[[Category: Ding D]]

OCA at 10:17, 18 May 2022

OCA — Wed, 18 May 2022 10:17:41 GMT

←Older revision		Revision as of 10:17, 18 May 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7vlr ~~is ON HOLD until Paper Publication~~	+	==Structure of SUR2B in complex with Mg-ATP/ADP==
-		+	<StructureSection load='7vlr' size='340' side='right'caption='[[7vlr]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VLR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vlr OCA], [https://pdbe.org/7vlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vlr RCSB], [https://www.ebi.ac.uk/pdbsum/7vlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vlr ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chen L]]
		+	[[Category: Ding D]]

OCA at 11:37, 4 May 2022

OCA — Wed, 04 May 2022 11:37:01 GMT

←Older revision		Revision as of 11:37, 4 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7vlr is ON HOLD	+	The entry 7vlr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7vlr" [edit=sysop:move=sysop]

OCA — Wed, 13 Oct 2021 10:34:29 GMT

Protected "7vlr" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:34, 13 October 2021

OCA: New page: '''Unreleased structure''' The entry 7vlr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Oct 2021 10:34:28 GMT

New page: '''Unreleased structure''' The entry 7vlr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7vlr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7vlr - Revision history

OCA at 10:21, 14 December 2022

OCA at 10:17, 18 May 2022

OCA at 11:37, 4 May 2022

OCA: Protected "7vlr" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7vlr is ON HOLD Authors: Description: Category: Unreleased Structures