OCA at 11:14, 16 February 2022

OCA — Wed, 16 Feb 2022 11:14:18 GMT

←Older revision		Revision as of 11:14, 16 February 2022
Line 1:		Line 1:

	==Al-bound structure of the AtALMT1 mutant M60A==		==Al-bound structure of the AtALMT1 mutant M60A==
-	<StructureSection load='7voj' size='340' side='right'caption='[[7voj]]' scene=''>	+	<StructureSection load='7voj' size='340' side='right'caption='[[7voj]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7voj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7voj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7voj OCA], [https://pdbe.org/7voj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7voj RCSB], [https://www.ebi.ac.uk/pdbsum/7voj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7voj ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=AL:ALUMINUM+ION'>AL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7voj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7voj OCA], [https://pdbe.org/7voj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7voj RCSB], [https://www.ebi.ac.uk/pdbsum/7voj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7voj ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/ALMT1_ARATH ALMT1_ARATH]] Malate transporter critical for aluminum tolerance. The STOP1 transcription factor is required for ALMT1 expression.<ref>PMID:16740662</ref> <ref>PMID:17885092</ref> <ref>PMID:18826429</ref> <ref>PMID:19321711</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The plant aluminum (Al)-activated malate transporter ALMT1 mediates the efflux of malate to chelate the Al in acidic soils and underlies the plant Al resistance. Here we present cryo-electron microscopy (cryo-EM) structures of Arabidopsis thaliana ALMT1 (AtALMT1) in the apo, malate-bound, and Al-bound states at neutral and/or acidic pH at up to 3.0 A resolution. The AtALMT1 dimer assembles an anion channel and each subunit contains six transmembrane helices (TMs) and six cytosolic alpha-helices. Two pairs of Arg residues are located in the center of the channel pore and contribute to malate recognition. Al binds at the extracellular side of AtALMT1 and induces conformational changes of the TM1-2 loop and the TM5-6 loop, resulting in the opening of the extracellular gate. These structures, along with electrophysiological measurements, molecular dynamic simulations, and mutagenesis study in Arabidopsis, elucidate the structural basis for Al-activated malate transport by ALMT1.
		+
		+	Structural basis of ALMT1-mediated aluminum resistance in Arabidopsis.,Wang J, Yu X, Ding ZJ, Zhang X, Luo Y, Xu X, Xie Y, Li X, Yuan T, Zheng SJ, Yang W, Guo J Cell Res. 2021 Nov 19. pii: 10.1038/s41422-021-00587-6. doi:, 10.1038/s41422-021-00587-6. PMID:34799726<ref>PMID:34799726</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7voj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wang J]]	+	[[Category: Wang, J]]
		+	[[Category: Almt1]]
		+	[[Category: Aluminum resistance]]
		+	[[Category: Malate transport]]
		+	[[Category: Transport protein]]

OCA at 06:23, 1 December 2021

OCA — Wed, 01 Dec 2021 06:23:18 GMT

←Older revision		Revision as of 06:23, 1 December 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7voj is ON HOLD~~	+	==Al-bound structure of the AtALMT1 mutant M60A==
-		+	<StructureSection load='7voj' size='340' side='right'caption='[[7voj]]' scene=''>
-	~~Authors: Wang, J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOJ FirstGlance]. <br>
-	~~Description:~~ Al-bound structure of the AtALMT1 mutant M60A	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7voj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7voj OCA], [https://pdbe.org/7voj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7voj RCSB], [https://www.ebi.ac.uk/pdbsum/7voj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7voj ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Wang, J]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Wang J]]

OCA: Protected "7voj" [edit=sysop:move=sysop]

OCA — Wed, 20 Oct 2021 15:18:32 GMT

Protected "7voj" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:18, 20 October 2021

OCA: New page: '''Unreleased structure''' The entry 7voj is ON HOLD Authors: Wang, J. Description: Al-bound structure of the AtALMT1 mutant M60A Category: Unreleased Structures [[Category: Wang, ...

OCA — Wed, 20 Oct 2021 15:18:31 GMT

New page: '''Unreleased structure''' The entry 7voj is ON HOLD Authors: Wang, J. Description: Al-bound structure of the AtALMT1 mutant M60A Category: Unreleased Structures [[Category: Wang, ...

New page

'''Unreleased structure'''

The entry 7voj is ON HOLD

Authors: Wang, J.

Description: Al-bound structure of the AtALMT1 mutant M60A
[[Category: Unreleased Structures]]
[[Category: Wang, J]]

7voj - Revision history

OCA at 11:14, 16 February 2022

OCA at 06:23, 1 December 2021

OCA: Protected "7voj" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7voj is ON HOLD Authors: Wang, J. Description: Al-bound structure of the AtALMT1 mutant M60A Category: Unreleased Structures [[Category: Wang, ...