7vov - Revision history

OCA at 17:29, 29 November 2023

OCA — Wed, 29 Nov 2023 17:29:20 GMT

←Older revision		Revision as of 17:29, 29 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7vov]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOV FirstGlance]. <br>		<table><tr><td colspan='2'>[[7vov]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vov OCA], [https://pdbe.org/7vov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vov RCSB], [https://www.ebi.ac.uk/pdbsum/7vov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vov ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.15Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vov OCA], [https://pdbe.org/7vov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vov RCSB], [https://www.ebi.ac.uk/pdbsum/7vov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vov ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN]] Blepharophimosis-ptosis-epicanthus inversus syndrome plus;Blepharophimosis-ptosis-epicanthus inversus syndrome type 2;Maligant granulosa cell tumor of the ovary;NON RARE IN EUROPE: Primary ovarian failure;Blepharophimosis-ptosis-epicanthus inversus syndrome type 1. The disease is caused by variants affecting the gene represented in this entry. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II. The disease is caused by variants affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN] Blepharophimosis-ptosis-epicanthus inversus syndrome plus;Blepharophimosis-ptosis-epicanthus inversus syndrome type 2;Maligant granulosa cell tumor of the ovary;NON RARE IN EUROPE: Primary ovarian failure;Blepharophimosis-ptosis-epicanthus inversus syndrome type 1. The disease is caused by variants affecting the gene represented in this entry. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN]] Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.<ref>PMID:16153597</ref> <ref>PMID:19010791</ref> <ref>PMID:19429596</ref> <ref>PMID:19744555</ref>	+	[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN] Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.<ref>PMID:16153597</ref> <ref>PMID:19010791</ref> <ref>PMID:19429596</ref> <ref>PMID:19744555</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:59, 7 September 2022

OCA — Wed, 07 Sep 2022 18:59:20 GMT

←Older revision		Revision as of 18:59, 7 September 2022
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	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN]] Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.<ref>PMID:16153597</ref> <ref>PMID:19010791</ref> <ref>PMID:19429596</ref> <ref>PMID:19744555</ref>		[[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN]] Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.<ref>PMID:16153597</ref> <ref>PMID:19010791</ref> <ref>PMID:19429596</ref> <ref>PMID:19744555</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although both the p53 and forkhead box (FOX) family proteins are key transcription factors associated with cancer progression, their direct relationship is unknown. Here, we found that FOX family proteins bind to the non-canonical homotypic cluster of the p53 promoter region (TP53). Analysis of crystal structures of FOX proteins (FOXL2 and FOXA1) bound to the p53 homotypic cluster indicated that they interact with a 2:1 stoichiometry accommodated by FOX-induced DNA allostery. In particular, FOX proteins exhibited distinct dimerization patterns in recognition of the same p53-DNA; dimer formation of FOXA1 involved protein-protein interaction, but FOXL2 did not. Biochemical and biological functional analyses confirmed the cooperative binding of FOX proteins to the TP53 promoter for the transcriptional activation of TP53. In addition, up-regulation of TP53 was necessary for FOX proteins to exhibit anti-proliferative activity in cancer cells. These analyses reveal the presence of a discrete characteristic within FOX family proteins in which FOX proteins regulate the transcription activity of the p53 tumor suppressor via cooperative binding to the TP53 promoter in alternative dimer configurations.
		+
		+	FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations.,Choi Y, Luo Y, Lee S, Jin H, Yoon HJ, Hahn Y, Bae J, Lee HH Nucleic Acids Res. 2022 Aug 26;50(15):8929-8946. doi: 10.1093/nar/gkac673. PMID:35920317<ref>PMID:35920317</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7vov" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:50, 7 September 2022

OCA — Wed, 07 Sep 2022 16:50:04 GMT

←Older revision		Revision as of 16:50, 7 September 2022
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	==The crystal structure of human forkhead box protein in complex with DNA 2==		==The crystal structure of human forkhead box protein in complex with DNA 2==
-	<StructureSection load='7vov' size='340' side='right'caption='[[7vov]]' scene=''>	+	<StructureSection load='7vov' size='340' side='right'caption='[[7vov]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7vov]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOV FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vov OCA], [https://pdbe.org/7vov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vov RCSB], [https://www.ebi.ac.uk/pdbsum/7vov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vov ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vov OCA], [https://pdbe.org/7vov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vov RCSB], [https://www.ebi.ac.uk/pdbsum/7vov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vov ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN]] Blepharophimosis-ptosis-epicanthus inversus syndrome plus;Blepharophimosis-ptosis-epicanthus inversus syndrome type 2;Maligant granulosa cell tumor of the ovary;NON RARE IN EUROPE: Primary ovarian failure;Blepharophimosis-ptosis-epicanthus inversus syndrome type 1. The disease is caused by variants affecting the gene represented in this entry. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/FOXL2_HUMAN FOXL2_HUMAN]] Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.<ref>PMID:16153597</ref> <ref>PMID:19010791</ref> <ref>PMID:19429596</ref> <ref>PMID:19744555</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Choi Y]]		[[Category: Choi Y]]
	[[Category: Lee HH]]		[[Category: Lee HH]]
	[[Category: Yoon HJ]]		[[Category: Yoon HJ]]

OCA at 11:12, 31 August 2022

OCA — Wed, 31 Aug 2022 11:12:35 GMT

←Older revision		Revision as of 11:12, 31 August 2022
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-	====	+	==The crystal structure of human forkhead box protein in complex with DNA 2==
	<StructureSection load='7vov' size='340' side='right'caption='[[7vov]]' scene=''>		<StructureSection load='7vov' size='340' side='right'caption='[[7vov]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VOV FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vov OCA], [https://pdbe.org/7vov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vov RCSB], [https://www.ebi.ac.uk/pdbsum/7vov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vov ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vov OCA], [https://pdbe.org/7vov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vov RCSB], [https://www.ebi.ac.uk/pdbsum/7vov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vov ProSAT]</span></td></tr>
	</table>		</table>
Line 9:		Line 9:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Choi Y]]
		+	[[Category: Lee HH]]
		+	[[Category: Yoon HJ]]

OCA at 06:22, 18 August 2022

OCA — Thu, 18 Aug 2022 06:22:47 GMT

←Older revision		Revision as of 06:22, 18 August 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7vov ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7vov' size='340' side='right'caption='[[7vov]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vov OCA], [https://pdbe.org/7vov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vov RCSB], [https://www.ebi.ac.uk/pdbsum/7vov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vov ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:17, 1 December 2021

OCA — Wed, 01 Dec 2021 05:17:26 GMT

←Older revision		Revision as of 05:17, 1 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7vov is ON HOLD	+	The entry 7vov is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7vov" [edit=sysop:move=sysop]

OCA — Wed, 20 Oct 2021 15:19:10 GMT

Protected "7vov" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:19, 20 October 2021

OCA: New page: '''Unreleased structure''' The entry 7vov is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Oct 2021 15:19:09 GMT

New page: '''Unreleased structure''' The entry 7vov is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7vov is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]