7vw8 - Revision history

OCA at 17:33, 29 November 2023

OCA — Wed, 29 Nov 2023 17:33:27 GMT

←Older revision		Revision as of 17:33, 29 November 2023
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	<StructureSection load='7vw8' size='340' side='right'caption='[[7vw8]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='7vw8' size='340' side='right'caption='[[7vw8]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7vw8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VW8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7vw8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicoverpa_armigera Helicoverpa armigera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VW8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vw8 OCA], [https://pdbe.org/7vw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vw8 RCSB], [https://www.ebi.ac.uk/pdbsum/7vw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vw8 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vw8 OCA], [https://pdbe.org/7vw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vw8 RCSB], [https://www.ebi.ac.uk/pdbsum/7vw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vw8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F5ANH9_HELAM F5ANH9_HELAM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7vw8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7vw8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pheromone binding protein\|Pheromone binding protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Helicoverpa armigera]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Z]]	+	[[Category: Chen Z]]
-	[[Category: Zheng, J]]	+	[[Category: Zheng J]]
-	~~[[Category: Ligand binding mechanism]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 07:33, 2 March 2022

OCA — Wed, 02 Mar 2022 07:33:29 GMT

←Older revision		Revision as of 07:33, 2 March 2022
Line 1:		Line 1:

	==Helicoverpa armigera pheromone-binding protein PBP1 at pH 7.5==		==Helicoverpa armigera pheromone-binding protein PBP1 at pH 7.5==
-	<StructureSection load='7vw8' size='340' side='right'caption='[[7vw8]]' scene=''>	+	<StructureSection load='7vw8' size='340' side='right'caption='[[7vw8]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VW8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7vw8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VW8 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vw8 OCA], [https://pdbe.org/7vw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vw8 RCSB], [https://www.ebi.ac.uk/pdbsum/7vw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vw8 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vw8 OCA], [https://pdbe.org/7vw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vw8 RCSB], [https://www.ebi.ac.uk/pdbsum/7vw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vw8 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cotton bollworm (Helicoverpa armigera) is a worldwide agricultural pest in which the transport of pheromones is indispensable and perceived by pheromone-binding proteins (PBPs). However, three-dimensional structure, pheromone binding, and releasing mechanisms of PBPs are not completely illustrated. Here, we solved three structures of the cotton bollworm HarmPBP1 at different pH values and its complex with ligand, Z-9-hexadecenal. Although apo-HarmPBP1 adopts a common PBP scaffold of six alpha-helices surrounding a predominantly hydrophobic central pocket, the conformation is greatly distinct from other apo-PBPs. The Z-9-hexadecenal is bound mainly by hydrophobic interaction. The pheromone can enter this cavity through an opening between the helices alpha5 and alpha6, as well as the loop between alpha3 and alpha4. Structural analysis suggests that ligand entry into the pocket is followed by a shift of Lys94 and Lys138, which may act as a lid at the opening of the pocket. Acidic pH will cause a subtle structural change of the lid, which in turn affects its ligand-binding ability, differently from other family proteins. Taken together, this study provides structural bases for the interactions between pheromones and PBPs, the pH-induced conformational switch, and the design of small inhibitors to control cotton bollworms by disrupting male-female chemosensory communication.
		+
		+	Structural Insights into the Ligand-Binding and -Releasing Mechanism of Helicoverpa armigera Pheromone-Binding Protein PBP1.,Zheng J, Yang M, Dong K, Zhang J, Wang H, Xie M, Wu W, Zhang YJ, Chen Z Int J Mol Sci. 2022 Jan 21;23(3). pii: ijms23031190. doi: 10.3390/ijms23031190. PMID:35163109<ref>PMID:35163109</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7vw8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen Z]]	+	[[Category: Chen, Z]]
-	[[Category: Zheng J]]	+	[[Category: Zheng, J]]
		+	[[Category: Ligand binding mechanism]]
		+	[[Category: Transport protein]]

OCA at 07:04, 2 February 2022

OCA — Wed, 02 Feb 2022 07:04:48 GMT

←Older revision		Revision as of 07:04, 2 February 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7vw8 ~~is ON HOLD until Paper Publication~~	+	==Helicoverpa armigera pheromone-binding protein PBP1 at pH 7.5==
-		+	<StructureSection load='7vw8' size='340' side='right'caption='[[7vw8]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VW8 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vw8 OCA], [https://pdbe.org/7vw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vw8 RCSB], [https://www.ebi.ac.uk/pdbsum/7vw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vw8 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chen Z]]
		+	[[Category: Zheng J]]

OCA: Protected "7vw8" [edit=sysop:move=sysop]

OCA — Wed, 17 Nov 2021 12:21:26 GMT

Protected "7vw8" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:21, 17 November 2021

OCA: New page: '''Unreleased structure''' The entry 7vw8 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 17 Nov 2021 12:21:25 GMT

New page: '''Unreleased structure''' The entry 7vw8 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7vw8 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]