7vzb - Revision history

OCA at 09:59, 22 June 2022

OCA — Wed, 22 Jun 2022 09:59:17 GMT

←Older revision		Revision as of 09:59, 22 June 2022
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vzb OCA], [https://pdbe.org/7vzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vzb RCSB], [https://www.ebi.ac.uk/pdbsum/7vzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vzb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vzb OCA], [https://pdbe.org/7vzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vzb RCSB], [https://www.ebi.ac.uk/pdbsum/7vzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vzb ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to peroxisome for beta-oxidation, dysfunction of which usually causes the X-linked adrenoleukodystrophy (X-ALD). Here, we report three cryogenic electron microscopy structures of ABCD1: the apo-form, substrate- and ATP-bound forms. Distinct from what was seen in the previously reported ABC transporters, the two symmetric molecules of behenoyl coenzyme A (C22:0-CoA) cooperatively bind to the transmembrane domains (TMDs). For each C22:0-CoA, the hydrophilic 3'-phospho-ADP moiety of CoA portion inserts into one TMD, with the succeeding pantothenate and cysteamine moiety crossing the inter-domain cavity, whereas the hydrophobic fatty acyl chain extends to the opposite TMD. Structural analysis combined with biochemical assays illustrates snapshots of ABCD1-mediated substrate transport cycle. It advances our understanding on the selective oxidation of fatty acids and molecular pathology of X-ALD.
		+
		+	Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1.,Chen ZP, Xu D, Wang L, Mao YX, Li Y, Cheng MT, Zhou CZ, Hou WT, Chen Y Nat Commun. 2022 Jun 8;13(1):3299. doi: 10.1038/s41467-022-30974-5. PMID:35676282<ref>PMID:35676282</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7vzb" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:18, 25 May 2022

OCA — Wed, 25 May 2022 08:18:52 GMT

←Older revision		Revision as of 08:18, 25 May 2022
Line 1:		Line 1:

	==Cryo-EM structure of C22:0-CoA bound human very long-chain fatty acid ABC transporter ABCD1==		==Cryo-EM structure of C22:0-CoA bound human very long-chain fatty acid ABC transporter ABCD1==
-	<StructureSection load='7vzb' size='340' side='right'caption='[[7vzb]]' scene=''>	+	<StructureSection load='7vzb' size='340' side='right'caption='[[7vzb]], [[Resolution\|resolution]] 3.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7vzb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VZB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vzb OCA], [https://pdbe.org/7vzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vzb RCSB], [https://www.ebi.ac.uk/pdbsum/7vzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vzb ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FFI:S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl]+docosanethioate'>FFI</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vzb OCA], [https://pdbe.org/7vzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vzb RCSB], [https://www.ebi.ac.uk/pdbsum/7vzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vzb ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen YX]]	+	[[Category: Chen, Y X]]
-	[[Category: Chen ZP]]	+	[[Category: Chen, Z P]]
-	[[Category: Cheng MT]]	+	[[Category: Cheng, M T]]
-	[[Category: Hou WT]]	+	[[Category: Hou, W T]]
-	[[Category: Mao YX]]	+	[[Category: Mao, Y X]]
-	[[Category: Wang L]]	+	[[Category: Wang, L]]
-	[[Category: Xu D]]	+	[[Category: Xu, D]]
-	[[Category: Yang L]]	+	[[Category: Yang, L]]
-	[[Category: Zhou CZ]]	+	[[Category: Zhou, C Z]]
		+	[[Category: Abc transporter]]
		+	[[Category: Peroxisome]]
		+	[[Category: Transport protein]]
		+	[[Category: Very long-chain fatty]]

OCA at 10:17, 18 May 2022

OCA — Wed, 18 May 2022 10:17:55 GMT

←Older revision		Revision as of 10:17, 18 May 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7vzb is ~~ON HOLD~~	+	==Cryo-EM structure of C22:0-CoA bound human very long-chain fatty acid ABC transporter ABCD1==
-		+	<StructureSection load='7vzb' size='340' side='right'caption='[[7vzb]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VZB FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vzb OCA], [https://pdbe.org/7vzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vzb RCSB], [https://www.ebi.ac.uk/pdbsum/7vzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vzb ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chen YX]]
		+	[[Category: Chen ZP]]
		+	[[Category: Cheng MT]]
		+	[[Category: Hou WT]]
		+	[[Category: Mao YX]]
		+	[[Category: Wang L]]
		+	[[Category: Xu D]]
		+	[[Category: Yang L]]
		+	[[Category: Zhou CZ]]

OCA: Protected "7vzb" [edit=sysop:move=sysop]

OCA — Wed, 24 Nov 2021 11:08:32 GMT

Protected "7vzb" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:08, 24 November 2021

OCA: New page: '''Unreleased structure''' The entry 7vzb is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 24 Nov 2021 11:08:31 GMT

New page: '''Unreleased structure''' The entry 7vzb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7vzb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]