7w3w - Revision history

OCA at 17:35, 29 November 2023

OCA — Wed, 29 Nov 2023 17:35:50 GMT

←Older revision		Revision as of 17:35, 29 November 2023
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	<StructureSection load='7w3w' size='340' side='right'caption='[[7w3w]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='7w3w' size='340' side='right'caption='[[7w3w]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7w3w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W3W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7w3w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_metschnikovii Vibrio metschnikovii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W3W FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w3w OCA], [https://pdbe.org/7w3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w3w RCSB], [https://www.ebi.ac.uk/pdbsum/7w3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w3w ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.858Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w3w OCA], [https://pdbe.org/7w3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w3w RCSB], [https://www.ebi.ac.uk/pdbsum/7w3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w3w ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lu, P]]	+	[[Category: Vibrio metschnikovii]]
-	[[Category: Nagata, K]]	+	[[Category: Lu P]]
-	[[Category: Sui, M]]	+	[[Category: Nagata K]]
-	[[Category: Zhang, M]]	+	[[Category: Sui M]]
-	~~[[Category: Abc transporter]]~~	+	[[Category: Zhang M]]
-	~~[[Category: Fbpa]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 11:15, 16 February 2022

OCA — Wed, 16 Feb 2022 11:15:29 GMT

←Older revision		Revision as of 11:15, 16 February 2022
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	==X-ray structure of apo-VmFbpA, a ferric ion-binding protein from Vibrio metschnikovii==		==X-ray structure of apo-VmFbpA, a ferric ion-binding protein from Vibrio metschnikovii==
-	<StructureSection load='7w3w' size='340' side='right'caption='[[7w3w]]' scene=''>	+	<StructureSection load='7w3w' size='340' side='right'caption='[[7w3w]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W3W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7w3w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W3W FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w3w OCA], [https://pdbe.org/7w3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w3w RCSB], [https://www.ebi.ac.uk/pdbsum/7w3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w3w ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w3w OCA], [https://pdbe.org/7w3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w3w RCSB], [https://www.ebi.ac.uk/pdbsum/7w3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w3w ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: New strategies are needed to combat multidrug-resistant bacteria. The restriction of iron uptake by bacteria is a promising way to inhibit their growth. We aimed to suppress the growth of Vibrio bacterial species by inhibiting their ferric ion-binding protein (FbpA) using food components. METHODS: Twenty spices were selected for the screening of FbpA inhibitors. The candidate was applied to antibacterial tests, and the mechanism was further studied. RESULTS: An active compound, rosmarinic acid (RA), was screened out. RA binds competitively and more tightly than Fe(3+) to VmFbpA, the FbpA from V. metschnikovii, with apparent KD values of 8 muM vs. 17 muM. Moreover, RA can inhibit the growth of V. metschnikovii to one-third of the control at 1000 muM. Interestingly, sodium citrate (SC) enhances the growth inhibition effect of RA, although SC only does not inhibit the growth. The combination of RA/SC completely inhibits the growth of not only V. metschnikovii at 100/100 muM but also the vibriosis-causative pathogens V. vulnificus and V. parahaemolyticus, at 100/100 and 1000/100 muM, respectively. However, RA/SC does not affect the growth of Escherichia coli. CONCLUSIONS: RA/SC is a potential bacteriostatic agent against Vibrio species while causing little damage to indigenous gastrointestinal bacteria.
		+
		+	Rosmarinic Acid and Sodium Citrate Have a Synergistic Bacteriostatic Effect against Vibrio Species by Inhibiting Iron Uptake.,Lu P, Sui M, Zhang M, Wang M, Kamiya T, Okamoto K, Itoh H, Okuda S, Suzuki M, Asakura T, Fujiwara T, Nagata K Int J Mol Sci. 2021 Dec 1;22(23). pii: ijms222313010. doi: 10.3390/ijms222313010. PMID:34884815<ref>PMID:34884815</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7w3w" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lu P]]	+	[[Category: Lu, P]]
-	[[Category: Nagata K]]	+	[[Category: Nagata, K]]
-	[[Category: Sui M]]	+	[[Category: Sui, M]]
-	[[Category: Zhang M]]	+	[[Category: Zhang, M]]
		+	[[Category: Abc transporter]]
		+	[[Category: Fbpa]]
		+	[[Category: Iron]]
		+	[[Category: Metal binding protein]]

OCA at 16:51, 15 December 2021

OCA — Wed, 15 Dec 2021 16:51:39 GMT

←Older revision		Revision as of 16:51, 15 December 2021
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-	'''Unreleased structure'''

-	~~The entry 7w3w is ON HOLD until Paper Publication~~	+	==X-ray structure of apo-VmFbpA, a ferric ion-binding protein from Vibrio metschnikovii==
-		+	<StructureSection load='7w3w' size='340' side='right'caption='[[7w3w]]' scene=''>
-	~~Authors: Lu, P., Sui, M., Zhang, M., Nagata, K.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W3W FirstGlance]. <br>
-	~~Description:~~ X-ray structure of apo-VmFbpA, a ferric ion-binding protein from Vibrio metschnikovii	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w3w OCA], [https://pdbe.org/7w3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w3w RCSB], [https://www.ebi.ac.uk/pdbsum/7w3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w3w ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Zhang, M~~]]	+	__TOC__
-	[[Category: Nagata, K]]	+	</StructureSection>
-	[[Category: Sui, M]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lu, P~~]]	+	[[Category: Lu P]]
		+	[[Category: Nagata K]]
		+	[[Category: Sui M]]
		+	[[Category: Zhang M]]

OCA at 08:43, 8 December 2021

OCA — Wed, 08 Dec 2021 08:43:32 GMT

←Older revision		Revision as of 08:43, 8 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7w3w is ON HOLD	+	The entry 7w3w is ON HOLD until Paper Publication

	Authors: Lu, P., Sui, M., Zhang, M., Nagata, K.		Authors: Lu, P., Sui, M., Zhang, M., Nagata, K.

-	Description: X-ray structure of apo-VmFbpA, a ferric ion-binding protein from ~~vibrio~~ metschnikovii	+	Description: X-ray structure of apo-VmFbpA, a ferric ion-binding protein from Vibrio metschnikovii
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Lu, P]]
	[[Category: Zhang, M]]		[[Category: Zhang, M]]
	[[Category: Nagata, K]]		[[Category: Nagata, K]]
	[[Category: Sui, M]]		[[Category: Sui, M]]
		+	[[Category: Lu, P]]

OCA: Protected "7w3w" [edit=sysop:move=sysop]

OCA — Wed, 01 Dec 2021 05:21:56 GMT

Protected "7w3w" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:21, 1 December 2021

OCA: New page: '''Unreleased structure''' The entry 7w3w is ON HOLD Authors: Lu, P., Sui, M., Zhang, M., Nagata, K. Description: X-ray structure of apo-VmFbpA, a ferric ion-binding protein from vibri...

OCA — Wed, 01 Dec 2021 05:21:55 GMT

New page: '''Unreleased structure''' The entry 7w3w is ON HOLD Authors: Lu, P., Sui, M., Zhang, M., Nagata, K. Description: X-ray structure of apo-VmFbpA, a ferric ion-binding protein from vibri...

New page

'''Unreleased structure'''

The entry 7w3w is ON HOLD

Authors: Lu, P., Sui, M., Zhang, M., Nagata, K.

Description: X-ray structure of apo-VmFbpA, a ferric ion-binding protein from vibrio metschnikovii
[[Category: Unreleased Structures]]
[[Category: Lu, P]]
[[Category: Zhang, M]]
[[Category: Nagata, K]]
[[Category: Sui, M]]